Bilobil intensive capsules 120mg №10×6

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Bilobil intensive caps 120mg in a blister pack No. 10×6
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Brown capsules. Main active ingredient Ginkgo biloba leaf extract Release form Capsules Dosage 120 mg In the event of hypersensitivity reactions, the capsules should be discontinued. Before surgery, the patient must inform the doctor that he is taking Bilobil Intens capsules. Patients with a tendency to spontaneous bleeding (hemorrhagic diathesis) and patients who are taking drugs to prevent increased blood clotting should consult a doctor before starting treatment with Bilobil Intens capsules. Patients taking hypoglycemic and antihypertensive drugs should consult a doctor before starting treatment with Bilobil Intens. The drug contains lactose and glucose. Patients with rare hereditary problems of galactose intolerance, lactase enzyme deficiency or glucose/galactose malabsorption should not take this medicine. Use in pediatrics Bilobil intensive is not recommended for children due to limited data on the safety of use in this category of patients. Pharmacological action Bilobil® intensive capsules contain a standardized extract of ginkgo biloba leaves, the effectiveness of which has been proven in randomized clinical trials involving patients with dementia, cerebrovascular insufficiency (vertigo, tinnitus), peripheral arterial occlusive lesions, circulatory disorders of the extremities. The main active markers of dry extract of ginkgo biloba leaves are flavonol glycosides and terpene lactones (ginkgolides and bilobalide). In vitro studies have established the following pharmacological effects of ginkgo biloba extract: prevention of the development of traumatic and toxic cerebral edema, inhibition of PAF (platelet activating factor), inactivation of toxic oxygen radicals; increased hypoxic tolerance, prevention of age-related changes in cholinergic receptors and ?2-adrenergic receptors, neuroprotective effect , improvement of blood perfusion, especially microcirculation, inactivation of toxic oxygen radicals, prevention of the development of traumatic and toxic cerebral edema. Mild or moderate dementia syndrome (primary degenerative dementia, vascular dementia or mixed form) dementia or cerebrovascular insufficiency after the appointment of 120-240 mg of dry extract of ginkgo biloba leaves per day showed an improvement in cognitive abilities, especially memory and attention. In a multicenter clinical trial in 400 patients with Alzheimer’s disease, a statistically significant improvement in cognitive and non-cognitive symptoms of dementia was shown after 22 weeks of treatment with Ginkgo biloba leaf dry extract at a dose of 240 mg / In addition, compared with the placebo group, there was a significant improvement in test series scores CT (Kurza Syndrome Test), neuropsychiatric symptoms of dementia, and improved performance in basic self-care activities. Peripheral Arterial Occlusion Ginkgo biloba leaf dry extract has been validated in nine double-blind, placebo-controlled clinical trials in patients with peripheral arterial occlusive disease (Fontaine stage II). Dry extract of Ginkgo biloba leaves improves the symptomatology of intermittent claudication, which manifests itself as an increase in the distance of pain-free walking. Indications for use Symptomatic treatment for: disorders of cerebral circulation and brain function (dementia syndrome in primary degenerative dementia, vascular dementia or a mixed form), manifested by memory loss and mental performance, dizziness, tinnitus, apathy, headache and sleep disturbance; the initial stage of circulatory disorders of the extremities, manifested by a feeling of cold, tingling, numbness, pain when walking. Dosage and administration In case of disorders of cerebral circulation and brain function (dementia syndrome in primary degenerative dementia, vascular dementia or mixed form), 1 caps is prescribed. 2 times/day in the morning and in the evening. At the initial stage of circulatory disorders of the extremities – 1 caps. 1 time / day, preferably in the morning. Capsules should be swallowed whole with water, regardless of the meal. The first signs of improvement usually appear 1 month after the start of treatment. To achieve a long-term effect, especially recommended for elderly patients, the course of treatment should be carried out for at least 3 months. Conducting a second course is possible after consultation with a doctor. In case of missing the time of the next intake of Bilobil Intens, you should take the capsule as soon as possible. If the time has already come for the next intake of Bilobil Intens, you should not take the drug in a double dose, but you need to continue taking it according to the usual scheme. Use during pregnancy and lactation There are no data on the possibility and safety of the drug during pregnancy and during breastfeeding. Interaction with other drugsDrug interaction studies have been conducted in adult patients. Simultaneous administration of Bilobil Intens is not recommended with the following drugs: drugs that reduce blood clotting (coumarin anticoagulants, acetylsalicylic acid and other NSAIDs). Simultaneous treatment with these drugs may increase the risk of bleeding due to prolongation of blood clotting time. The simultaneous use of Bilobil Intens with the following drugs requires special care: anticonvulsants (for example, phenytoin). The combined use of these drugs can lower the convulsive threshold and increase the possibility of developing an epileptic attack. Dry extract of ginkgo biloba leaves in vitro significantly increased the metabolism of anticonvulsants, which occurs with the participation of CYP2C enzymes. drugs metabolized by the cytochrome P450 enzyme system. Based on the results of the studies, the interaction of ginkgo biloba extract with drugs metabolized by the cytochrome P450 enzyme system cannot be completely ruled out. Contraindications Hypersensitivity to ginkgo biloba extract or other components of the drug. Composition 1 capsule contains dry, purified and standardized ginkgo biloba leaf extract (35-67:1) 120 mg, incl. flavonoids (in the form of flavonoid glycosides) 26.4-32.4 mg, ginkgolides A, B, C 3.36-4.08 mg, bilobalide 3.12-3.84 mg There have been no reports of poisoning with the standardized dry extract of ginkgo biloba leaves in humans. Side effects Gastrointestinal side effects: very rarely CNS side effects: very rarely Allergic reactions: very rarely Side effects that may occur during treatment with ginkgo biloba extract are classified into the following groups depending on the frequency of occurrence: very frequent (> 1/10) , frequent (> 1/100 to 1/1000 to 1/10,000 to Within each group, the side effects of the drug are presented in order of decreasing significance. Storage conditions The drug should be stored out of the reach of children, protected from moisture at a temperature not exceeding 25 ° C. 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