Aspirin C effervescent tablets 400mg/240mg №2×5

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Aspirin C tab.ship.400mg/240mg in strip.in pack No. 2×5
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Round, flat, beveled to the edge white tablets with an imprint in the form of a branded BAYER cross on one side. The main active ingredient Acetylsalicylic acid + ascorbic acid Release form Effervescent tablets Dosage 400 mg + 240 mg Pharmacological properties Acetylsalicylic acid has an analgesic, antipyretic, anti-inflammatory effect associated with the suppression of cyclooxygenases 1 and 2, which regulate the synthesis of prostaglandins; inhibits platelet aggregation. Ascorbic acid plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and helps to increase the body’s resistance. Indications for use For symptomatic relief of moderate or mild pain syndrome of various origins (headache, toothache, pain during menstruation, sore throat from infections, pain in the joints and muscles). Increased body temperature in infectious and inflammatory diseases. It is recommended to pay attention to the information regarding the use in children and adolescents (see section “Precautions”). Dosage and administration Use during pregnancy and lactation In the first and second trimester of pregnancy, the drug should not be used; short-term administration of the drug in low doses (not higher than 150 mg) is possible as prescribed by a doctor only if the expected benefit to the mother outweighs the potential risk to the fetus. In the III trimester of pregnancy, the use of the drug is contraindicated. If necessary, the use of the drug during lactation, breastfeeding should be discontinued. There is evidence that drugs that inhibit the synthesis of prostaglandins can impair a woman’s fertility by affecting the process of ovulation. This is the basis for stopping treatment. Precautions Concerning the use of acetylsalicylic acid in case of hypersensitivity to other analgesics, anti-inflammatory or antirheumatic drugs or other allergenic substances; in the presence of allergies (for example, skin reactions, itching, urticaria), asthma, hay fever, nasal polyposis or chronic respiratory infections; in concomitant therapy anticoagulants; with ulcerative lesions of the stomach or intestines (in history), or a tendency to gastrointestinal bleeding; with impaired liver function; with impaired renal and cardiovascular function (for example, vascular disease of the kidneys, congestive heart failure, dehydration, major surgery, sepsis or extensive hemorrhagic manifestations), since acetylsalicylic acid will contribute to the risk of impaired renal function and the development of acute renal failure; before surgery (including minor operations such as tooth extraction), as bleeding may increase; in patients with severe glucose deficiency – 6-phosphate dehydrogenase acetylsalicylic acid can cause hemolysis or hemolytic anemia. Contributing factors: high dose, high temperature or acute infection. Concerning the use of ascorbic acid with a predisposition to the formation of urinary stones from calcium oxalate; with thalassemia, hemochromatosis. Other precautions One effervescent tablet contains 20.3 mmol (466.4 mg) sodium. This should be considered by patients on a controlled sodium (low sodium/salt) diet. Prolonged use of analgesics can lead to headaches, which, when treated with additional analgesics, can lead to prolonged headaches. Regular use of analgesics can lead to chronic kidney damage with a risk of kidney failure (analgesic nephropathy). This risk is especially great when several different analgesics are taken at the same time. In small doses, acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an attack of gout in patients with a predisposition to reduced renal excretion. Children and adolescents Children and adolescents with high fever should only take acetylsalicylic acid as directed by a doctor and if other therapeutic measures have failed. Prolonged vomiting in the presence of such a disease may be a sign of Reis syndrome, a very rare but life-threatening disease that requires immediate treatment. Interaction with other drugs Increased action up to increased risk of side effects: anticoagulants / thrombolytics: acetylsalicylic acid may increase the risk of bleeding if taken before thrombolytic treatment. Therefore, attention should be paid to signs of external or internal bleeding in patients who plan to undergo treatment with thrombolytics. platelet aggregation inhibitors, for example, ticlopidine, clopidogrel: increased risk of bleeding; other non-steroidal analgesics / anti-inflammatory drugs (at doses of 3 g of acetylsalicylic acid per day or more ): increased risk of ulcerative lesions and bleeding in the gastrointestinal tract; systemic glucocorticosteroids (with the exception of hydrocortisone used in replacement therapy for Addison’s disease): increased risk of gastrointestinal side effects; alcohol: increased risk of ulcerative lesions and bleeding in gastrointestinal tract; digoxin: increased plasma concentrations; antidiabetic drugs: blood glucose levels may decrease; methotrexate: decreased excretion from the body and displacement of salicylates from association with proteins; valproic acid: displacement of salicylates from association with proteins proteins; selective serotonin reuptake inhibitors (SSRIs): increased risk of gastrointestinal bleeding due to a synergistic effect. Weakening of action: diuretics (in combination with doses of acetylsalicylic acid 3 g per day and above); angiotensin-converting enzyme inhibitors (in combination with doses acetylsalicylic acid 3 g per day and above); uricosuric drugs (for example, probenecid, benzbromarone) deferoxamine: simultaneous use with ascorbic acid can increase tissue toxicity of iron, especially in the myocardium, and cause cardiac decompensation. Contraindications hypersensitivity to salicylates or components of the drug; asthma caused by taking salicylates or other NSAIDs; erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase); hemorrhagic diathesis; hemophilia, thrombocytopenia; severe violations of the liver, kidneys and heart; combined use of methotrexate at a dose of 15 mg per week or more; III trimester pregnancy. Composition Active ingredients: acetyls alicylic acid 400 mg, ascorbic acid (vitamin C) 240 mg; excipients: sodium dihydrocitrate, sodium bicarbonate, anhydrous citric acid, anhydrous sodium carbonate. Overdose Moderate intoxication: tinnitus, hearing impairment, sweating, nausea, vomiting, headache and dizziness in all cases of overdose. This intoxication can be eliminated by dose reduction. Severe intoxication: high fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, acute hypoglycemia. Treatment: in case of signs of poisoning, induce vomiting or do a gastric lavage, prescribe activated charcoal and a laxative, and consult a doctor. Intoxication is more likely in older patients and especially in young children (therapeutic overdose or accidental intoxication can be fatal for them). Side effect On the part of the circulatory and lymphatic system: rarely and very rarely – serious bleeding, such as intracerebral hemorrhage (especially in patients with uncontrolled hypertension and / or concomitant use of antihemostatic drugs), which in some cases may be life threatening. Hemolysis and hemolytic anemia in patients with severe forms of glucose-6-phosphate dehydrogenase deficiency. Bleeding such as epistaxis, bleeding gums or skin bleeding, possible prolonged bleeding from the genitourinary system (see Precautions section). This effect may last up to 4-8 days after administration. Gastrointestinal tract: often – abdominal pain, nausea, vomiting, heartburn; rarely – ulcerative lesions of the gastrointestinal tract, which in very rare cases can lead to perforation; gastrointestinal bleeding, which in very rare cases can lead to iron deficiency anemia; inflammation of the gastrointestinal tract. CNS: headache, dizziness, tinnitus, hearing loss, confusion. Urinary system: at high doses – hyperoxaluria and the formation of urinary stones, damage to the glomerular apparatus of the kidneys. From the skin and subcutaneous tissues: infrequently – skin hypersensitivity reactions; rarely – severe skin hypersensitivity reactions (up to multiform exudative erythema). Immune system: rarely – hypersensitivity reactions from the respiratory tract, gastrointestinal tract, cardiovascular system, especially in asthmatics: pressure drop, shortness of breath, rhinitis, nasal congestion, anaphylactic shock, Quincke’s edema are possible. From the side of the liver and biliary tract: very rarely – an increase in the liver is indicative. From the side of the kidneys and urinary system: impaired renal function and acute renal failure. If such symptoms appear, it is recommended to stop taking the drug and consult a doctor. Reporting adverse reactions In case of any adverse reactions, you should consult your doctor. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the National Adverse Drug Reaction Information Database, including information on drug failures. By reporting adverse reactions, you help to get more information about the safety of the drug. Storage conditions At a temperature not exceeding 25 ° C, out of the reach of children. Buy Aspirin C effervescent tablets 400mg / 240mg No. 2×5 Price for Aspirin C effervescent tablets 400mg / 240mg No. 2×5