Name:
Efferalgan tab.ship. 500mg per cont. silent pack. (strips) No. 4×4
Description:
Effervescent tablets, white, round, flat, with bevelled edges and a notch on one side; when dissolved in water, an intensive release of gas bubbles is observed. when dissolved in water, an intensive release of gas bubbles is observed. 1 tab. paracetamol 500 mg Excipients: anhydrous citric acid – 1114.00 mg, sodium bicarbonate – 942.00 mg, anhydrous sodium carbonate – 332.00 mg, sorbitol – 300.00 mg, sodium saccharinate – 7.00 mg, sodium docusate – 0.227 mg, povidone – 1.287 mg, sodium benzoate – 60.606 mg. 4 things. – strips (4) – packs of cardboard. Dosage 500mg No. 16 Special instructions In case of ongoing febrile syndrome against the background of the use of paracetamol for more than 3 days, and pain syndrome – more than 5 days, a doctor’s consultation is required. Distorts the indicators of laboratory studies in the quantitative determination of the content of uric acid in plasma. To avoid toxic liver damage, paracetamol should not be combined with the intake of alcoholic beverages, and should not be taken by persons prone to chronic alcohol consumption. The risk of developing liver damage increases in patients with alcoholic hepatosis. With prolonged use of the drug, it is necessary to control the pattern of peripheral blood and the functional state of the liver. Efferalgan contains 412.4 mg of sodium per 1 tablet, which should be taken into account by patients on a strict low-salt diet. The tablets contain sorbitol, so the drug should not be used in case of fructose intolerance, low absorption of glucose and galactose, isomaltase deficiency. Pharmacological action Analgesic-antipyretic. It has an analgesic and antipyretic effect. Inhibits COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of its anti-inflammatory effect. It does not adversely affect the water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa due to the lack of influence on the synthesis of prostaglandins in peripheral tissues. The possibility of the formation of methemoglobin is unlikely. Pharmacokinetics Data on the pharmacokinetics of Efferalgan are not available. Indications for use – pain syndrome of mild or moderate intensity: headache, toothache, migraine, neuralgia, muscle pain, back pain, pain from injuries and burns, sore throat, algomenorrhea; – increased body temperature with colds and other infectious and inflammatory diseases. Dosage and administration The tablet should be dissolved in a glass of water (200 ml) and drunk. Assign inside 0.5-1 g (1-2 tablets) 2-3 times / day at intervals of at least 4 hours. The maximum single dose is 1 g (2 tablets), daily – 4 g (8 tablets). In patients with impaired liver or kidney function and elderly patients, the daily dose should be reduced, the interval between doses of the drug should be at least 8 hours. The duration of treatment (without consulting a doctor) is no more than 5 days when used as an analgesic and 3 days – as an antipyretic. Application during pregnancy and lactation The use of the drug in the I and III trimesters of pregnancy and lactation (breastfeeding) is contraindicated. Precautions The drug should be used with caution in hepatic insufficiency. The drug should be used with caution in renal failure. Contraindicated: children under 15 years of age (body weight less than 50 kg). The drug should be used with caution in elderly patients. Interaction with other drugs Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe intoxication with a slight overdose of the drug. Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol. Paracetamol reduces the effectiveness of uricosuric drugs. With simultaneous use with paracetamol, ethanol contributes to the development of acute pancreatitis. Contraindications – chronic alcoholism; – deficiency of glucose-6-phosphate dehydrogenase; – I and III trimesters of pregnancy; – lactation period (breastfeeding); – children’s age up to 15 years (body weight less than 50 kg); – Hypersensitivity to the components of the drug. The drug should be used with caution in renal and / or liver failure, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcoholic liver damage, in elderly patients. Composition 1 tab. paracetamol 500 mg Excipients: anhydrous citric acid – 1114.00 mg, sodium bicarbonate – 942.00 mg, anhydrous sodium carbonate – 332.00 mg, sorbitol – 300.00 mg, sodium saccharinate – 7.00 mg, sodium docusate – 0.227 mg, povidone – 1.287 mg, sodium benzoate – 60.606 mg. 4 things. – strips (4) – packs of cardboard. Overdose Symptoms: pallor of the skin, anorexia, nausea, vomiting; hepatonecrosis (the severity of necrosis due to intoxication directly depends on the degree of overdose). Toxic effects in adults are possible after taking paracetamol at a dose of more than 10-15 g: increased activity of hepatic transaminases, increased prothrombin time (12-48 hours after administration); a detailed clinical picture of liver damage appears after 1-6 days. Rarely – fulminant development of liver failure, which may be complicated by renal failure (tubular necrosis). Treatment: in the first 6 hours after an overdose – gastric lavage, the introduction of donators of SH groups and precursors of the synthesis of glutathione – methionine 8-9 hours after an overdose and N-acetylcysteine 12 hours later. The need for additional therapeutic measures (further administration of methionine, in / in the introduction of N-acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as the time elapsed after its administration. Side effects Allergic reactions: sometimes – skin rash, itching, Quincke’s edema. From the hemopoietic system: rarely – anemia, thrombocytopenia, methemoglobinemia. Others: with prolonged use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases (control of the peripheral blood picture is necessary). The drug is well tolerated at recommended doses. Storage conditions The drug should be stored out of the reach of children, in a dry place at a temperature not exceeding 30°C. Buy Efferalgan effervescent tablets 500mg No. 4×4 Price for Efferalgan effervescent tablets 500mg No. 4×4
Efferalgan effervescent tablets 500mg №4×4
$20.00
INN | PARACETAMOL |
---|---|
The code | 1 380 |
Barcode | 3 585 553 246 473 |
Dosage | 500mg |
Active substance | Paracetamol |
Manufacturer | UPSA SAS, France |
Importer | "VitPharmMarket" LLC Vitebsk, Republic of Belarus, 210004 Vitebsk, 5th Kooperativnaya st., 8; ALC "Dominantafarm", Minsk, 220140 Minsk, Dombrovskaya st., 15, room 10a, room 10a-41; Closed joint-stock company "Unipharm", 223060, Minsk region, Novodvorsky s / council, 40-1, room. 36, area of the village of Bolshoye Stiklevo; Foreign unitary trade and manufacturing enterprise "Belinvestfarma", Minsk, Leshchinskogo st., 8/4-2; ODO "TISHAS", Minsk, 220028 Belarus, Minsk, Mayakovsky st., 144, room 7; LLC "LIGMATON", Republic of Belarus, Minsk region, Minsk district, Senitsky s / s, 68/3-3, Senitsa district., 223056; SOOO "Brititrade", 223021, Minsk district, Shchomyslitsky s / s, 18 |
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