AnGriMax capsules №10×2

Name:
AnGriMax
Description:
Cylindrical hard gelatin capsules No. 0 with hemispherical ends, yellow body and green cap. The main active ingredient Paracetamol + rimantadine + ascorbic acid + loratadine + rutoside + calcium carbonate Release form Capsules Dosage 20 pcs. Indications for use Etiotropic and symptomatic treatment of influenza, acute respiratory viral infections, febrile conditions due to viral damage to the respiratory tract in adults and children over 12 years of age. Dosage and administration Inside, after eating, drinking water. Children over 12 years old and adults – 2 capsules 2-3 times a day for 3-5 days while maintaining a febrile syndrome. If there is no improvement in well-being while taking the drug, stop and consult a doctor! Use during pregnancy and lactation Teratogenic effects: Pregnancy – category C. There are no adequate and well-controlled studies in pregnant women. Remantadine has been reported to cross the placenta in mice. Remantadine is embryotoxic in rats at a dose of 200 mg/kg/day (11 times the MRHD on a mg/m2 basis). At this dose, the embryotoxic effect consisted of an increase in fetal resorption in rats, and this dose also caused a variety of maternal effects including ataxia, tremors, seizures, and significant weight loss. No embryotoxicity was observed when rabbits were dosed up to 50 mg/kg/day (approximately 0.1 times the MRHD based on AUC), but evidence of developmental anomaly was noted as a change in the proportion of fetuses with 12 or 13 ribs. This ratio is usually around 50:50 in the litter, but after treatment with rimantadine 80:20. Non-teratogenic effects: Remantadine was administered to pregnant rats in the pre- and postpartum period at doses of 30, 60 and 120 mg/kg/day (1.7, 3.4 and 6.8 times the MRHD on a mg/m2 basis). Maternal toxicity during pregnancy was noted at two higher doses of rimantadine, and at the maximum dose of 120 mg/kg/day, there was an increase in mortality in the first 2-4 days postpartum. Decreased fertility of the F1 generation was also noted for the two higher doses. For these reasons, the drug is contraindicated in pregnancy. Nursing Mothers: Remantadine is contraindicated in lactating mothers due to side effects noted in the offspring of rats treated with rimantadine during the feeding period. Remantadine was found in the milk of rats depending on the dose: from 2 to 3 hours after ingestion. Precautions Interaction with other drugs If you need to take it together with other drugs, consult your doctor first. The combined use of paracetamol and rimantadine leads to a decrease in the maximum concentration and AQC of rimantadine by about 11%. Ascorbic acid reduces the Cach of rimantadine by 10%. Cimetidine reduces the clearance of rimantadine by 18%. Remantadine reduces the effectiveness of antiepileptic drugs. Paracetamol reduces the effectiveness of uricosuric drugs. Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with a small overdose. Prolonged use of barbiturates reduces the effectiveness of paracetamol. Ethanol contributes to the development of acute pancreatitis. Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxicity. Long-term combined use of paracetamol and other NSAIDs increases the risk of developing “analgesic” nephropathy and renal papillary necrosis, the onset of end-stage renal failure. Diflunisal increases the plasma concentration of paracetamol by 50% – the risk of developing hepatotoxicity. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug. Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g / day, it increases the bioavailability of ethinylestradiol (including that which is part of oral contraceptives). Reduces the effectiveness of heparin and indirect anticoagulants. Increases the risk of developing crystalluria in the treatment of salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids). Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. With simultaneous use reduces the chronotropic effect of isoprenaline. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of neuroleptics – phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. CYP3A4 inhibitors (including ketoconazole, erythromycin), CYP3A4 and CYP2D6 inhibitors (cimetidine, etc.) increase the concentration of loratadine in the blood. Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness of loratadine. Contraindications hypersensitivity to one or more components that make up the drug; pregnancy and lactation; children’s age up to 12 years. One capsule contains: paracetamol 180 mg, rimantadine hydrochloride 25 mg, ascorbic acid (as SC-coated ascorbic acid) 150 mg, loratadine 1.5 mg, rutin 10 mg, calcium (as calcium carbonate) – 4.45 mg. Overdose Symptoms: in the first 24 hours, pallor, nausea, vomiting and pain in the epigastric region, tremor, drowsiness, tachycardia, increased bilirubin in the blood, metabolic disorders, exacerbation of concomitant chronic diseases are possible. Treatment: cause a gag reflex, gastric lavage, intake of adsorbents, symptomatic therapy. You need to see a doctor. Side effects From the side of the central nervous system Rarely – headache, fatigue, irritability, dizziness, tremor, hyperkinesia. On the part of the gastrointestinal tract With a duration of admission for more than 7 days, damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, nausea, anorexia, flatulence, diarrhea are possible. On the part of the blood system With a duration of admission of more than 7 days – agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia. Allergic reactions Rarely – skin rash, itching, urticaria are possible. Storage conditions Store in a place protected from moisture and light at a temperature of 15°C to 25°C. Store in a place inaccessible to children. Buy AnGriMax capsules No. 10×2 Price for AnGriMax capsules No. 10×2 Instructions for use for AnGriMax capsules No. 10×2