Aflumed Kids powder for solution for oral administration in bags No. 10

Name:
Aflumed kids
Description:
Powder of white or almost white color with a raspberry smell. Soft lumps are allowed. The main active ingredient Paracetamol + chlorphenamine + ascorbic acid Release form powder for solution for oral administration 6.0 g of powder in a bag of combined material (paper, polyethylene, aluminum foil, polyethylene). Five or ten packs along with instructions for use in a pack of cardboard. Dosage 6 g Pharmacological action Paracetamol has an analgesic, antipyretic and weak anti-inflammatory effect. Ascorbic acid (vitamin C) increases the body’s resistance to infections. Chlorpheniramine maleate has an anti-allergic effect, relieves symptoms: runny nose, lacrimation, itching in the eyes and nose. Indications for use To relieve symptoms of colds and flu in children 6 to 12 years of age: clear nasal discharge, watery eyes, sneezing, headache and muscle pain and/or fever (fever). Dosage and administration For children from 6 to 12 years old, take orally, regardless of food intake, after dissolving the contents of 1-2 packets in 150 ml of warm water. If necessary, repeat the reception every 4-6 hours, but not more than 4 packets per day. The total duration of treatment should not exceed 3 days. In case of impaired liver function, the interval for taking the drug should be at least 8 hours. Use during pregnancy and lactation This medicinal product is intended for use in children. Not recommended for use during pregnancy and breastfeeding. Precautions Do not exceed the recommended dose. To avoid overdose, the drug should not be taken concomitantly with other antihistamines or acetaminophen, including those that are part of cold medicines. In case of signs of superinfection or persistence of symptoms, persistent fever for more than 3 days, treatment should be reviewed. Use with caution in epilepsy, severe cardiovascular disease, moderate renal or hepatic impairment, congenital hyperbilirubinemia (Gilbert’s syndrome), glaucoma, urinary retention, prostate enlargement, pyloroduodenal obstruction, asthma, bronchitis, thyrotoxicosis, severe hypertension, hereditary glucose deficiency -6-phosphate dehydrogenase, alcoholism, glutathione deficiency, hyperoxaluria, bleeding disorders, malignant neoplasms, hemochromatosis. Ascorbic acid may interfere with laboratory test results. Each sachet contains 5.689 g of sucrose, which should be taken into account for daily consumption in case of a low sugar diet or diabetes. Children The drug is not used in children under 6 years of age. Influence on the ability to drive a car or mechanisms: Given the ability of the drug to cause drowsiness, patients should be kept from activities that require increased concentration of attention within 4 hours after administration. Interaction with other drugs There are no data on drug interactions with Aflumed Kids. It is known about the following types of interaction with individual active substances. Paracetamol When the following drugs are co-administered with paracetamol, the following interactions may occur: anticonvulsants (phenytoin, barbiturates, carbamazepine), rifampicin and alcohol may increase the hepatotoxicity of paracetamol; co-administration of high doses of paracetamol with isoniazid or rifampicin may increase the risk of developing hepatotoxic syndrome; the rate of absorption of paracetamol may increase when taking metoclopramide and domperidone and decrease when taking cholestyramine; long-term use of coumarin derivatives (for example, warfarin) in conjunction with paracetamol may increase the effect and increase the risk of bleeding; patients taking oral anticoagulants should consult their physician. Monitoring of blood clotting is recommended. Tropisetron and granisetron, 5-hydroxytryptamine type 3 receptor antagonists, can completely suppress the analgesic effect of paracetamol through a pharmacodynamic interaction. The simultaneous use of paracetamol and AZT (zidovudine) increases the tendency for a decrease in the number of leukocytes (neutropenia). Therefore, paracetamol should not be taken with AZT unless advised by a doctor. Ascorbic acid Deferoxamine: Vitamin C can increase tissue toxicity of iron, especially in the myocardium, and cause cardiac decompensation. Chlorpheniramine maleate Monoamine oxidase (MAO) inhibitors should not be taken in combination with antihistamines due to potential CNS depressant side effects. They may also prolong and enhance the anticholinergic effect of antihistamines. Chlorpheniramine maleate can enhance the inhibitory effect on the central nervous system of many drugs and substances, reducing the speed of reaction and concentration. These are morphine derivatives (analgesics, antitussives), neuroleptics, tranquilizers, barbiturates, benzodiazepines, hypnotics, sedative antidepressants (amitriptyline, mianserin, mirtazapine, timipramine), H1 blockers with sedative action, centrally acting antihypertensives, baclofen, thalidomide. Ethanol enhances the sedative effect of chlorpheniramine maleate. Contraindications – children’s age up to 6 years; – increased individual sensitivity to the components of the drug; – abnormal liver function up to severe liver failure (> 9 on the Child-Pugh scale); – angle-closure glaucoma; – urinary retention associated with dysfunction of the prostate gland; – fructose intolerance, glucose / galactose malabsorption or sucrase-isomaltase deficiency (due to the presence of sugar in the composition); – joint reception of monoamine oxidase inhibitors (MAO) and within 2 weeks after their cancellation. Composition 1 package contains: active ingredients: paracetamol – 160.0 mg, chlorpheniramine maleate – 1.0 mg, ascorbic acid – 50.0 mg. excipients: anhydrous citric acid, Raspberry flavor, sugar (Extra). Overdose A single dose of paracetamol at a dose of 10 g or more for an adult and 150 mg / kg of body weight for a child leads to the development of cytolysis, which can lead to complete irreversible liver necrosis, liver failure, encephalopathy up to coma and death. The risk of overdose is increased in patients with risk factors such as: – long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John’s wort or other drugs that induce liver enzymes; – alcohol abuse; – probable glutathione deficiency (may occur with digestive disorders, cystic fibrosis, HIV infection, starvation, cachexia). Symptoms of an overdose of paracetamol: on the first day – pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may occur 12-48 hours after taking the drug. Changes in glucose metabolism and metabolic acidosis are possible. In severe poisoning, liver failure can progress to the development of encephalopathy, bleeding, hypoglycemia, cerebral edema, and death. If the patient complains of back pain, hematuria and proteinuria, acute renal failure with acute tubular necrosis should be suspected, which can occur even in the absence of liver damage. Treatment. In case of an overdose, emergency medical attention is required. The patient should be immediately taken to the hospital, even if there are no early symptoms of an overdose. Symptoms may be limited to nausea and vomiting and may not reflect the severity of the overdose or the risk of organ damage. The use of activated charcoal is advisable if no more than 1 hour has passed since the moment of taking the excess dose. Paracetamol plasma concentrations should be measured 4 hours or later after ingestion (concentrations measured earlier are unreliable). Treatment with N-acetylcysteine can be applied within 24 hours after an overdose, the maximum effect is observed within 8 hours, then the effectiveness decreases sharply. If necessary, N-acetylcysteine is administered intravenously to the patient according to the recommended doses. In the absence of vomiting, oral methionine can be used as an alternative in the outpatient phase of care. Symptoms of an overdose of chlorpheniramine: sedation, paradoxical CNS excitation, convulsions, dyspnea, anticholinergic effects, dystonic reactions and arrhythmia. Treatment. Symptomatic and supportive. Particular attention should be paid to cardiac, respiratory, renal and hepatic function, water and electrolyte balance. In the absence of contraindications and a recent overdose, activated charcoal can be used orally (this is most effective if no more than 1 hour has passed from the moment the drug was taken orally). Treatment of hypotension and arrhythmias should be started immediately. When seizures occur, diazepam is effective. In severe cases, hemoperfusion is possible. Ascorbic Acid: There is no evidence that this product may cause overdose when used as directed. High doses of ascorbic acid (more than 3 g) can cause temporary osmotic diarrhea and disruption of the gastrointestinal tract (nausea, stomach discomfort). Side effects The drug is well tolerated at recommended doses. The listed adverse drug reactions are based on literature data, so organization according to CIOMS III frequency categories is not possible. There are the following side effects: from the side of the central nervous system: headache, fatigue, dizziness, drowsiness, confusion and disorientation, anxiety, sleep disorders, coma, convulsions, dyskinesia, abnormal behavior; from the gastrointestinal tract: nausea, vomiting, dry mouth, stomach discomfort, pain in the epigastric region, loss of appetite, dyspepsia, diarrhea, constipation; from the cardiovascular system: palpitations, tachycardia, hypotension; from the endocrine system: hypoglycemia (up to the development of coma); on the part of the hematopoietic organs: anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency), thrombocytopenic purpura, leukopenia, pancytopenia, agranulocytosis, thrombocytopenia, methemoglobinemia; on the part of the respiratory system: bronchospasm in patients sensitive to acetylsalicylic acid or other NSAIDs, or exacerbation of bronchial asthma; from the liver and biliary tract: liver damage (usually without jaundice), hepatitis, as well as dose-dependent liver failure, liver necrosis (dose-dependent effect). Prolonged unjustified use can lead to liver fibrosis, cirrhosis of the liver; disorders of the skin and subcutaneous tissues: itching, skin rash, urticaria, allergic edema, Quincke’s edema, acute generalized exanthematous pustulosis, persistent drug rash, polymorphic erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome); from the immune system: hypersensitivity (for example, an allergic reaction, anaphylactic reaction, anaphylactic shock), a feeling of heat; on the part of the organs of vision: visual impairment, accommodation disorders, dry eyes, mydriasis; increased intraocular pressure; from the kidneys and urinary system: urinary retention. Reporting adverse reactions If you experience any adverse reactions, please consult your physician. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the adverse drug reactions (actions) information database, including reports of drug failures. By reporting adverse reactions, you help to get more information about the safety of the drug. Storage conditions In a place protected from moisture and light at a temperature not exceeding 25 ° C. Keep out of the reach of children! Shelf life 2 years. Do not use after the expiration date indicated on the package. Buy Aflumed Kids powder for oral solution in bags No. 10 Price for Aflumed Kids powder for oral solution in bags No. 10 oral administration in packages No. 10