Trialgin tablets 325mg/32mg/2mg №10×1

Name Trialgin tabl. substance Caffeine + paracetamol + chlorphenamine Release form tablets Dosage 325 mg / 32 mg / 2 mg in a box of 10 pcs. Indications for use Trialgin belongs to the pharmacotherapeutic group: Paracetamol in combination with other drugs. ATC code: N02BE51. International non-proprietary name of the main active ingredients: Paracetamol, Caffeine, Chlorphenamine. This combination allows Trialgin to be effective in the treatment of diseases accompanied by febrile or pain syndrome. Why is Trialgin effective for colds accompanied by chills, fever, runny nose and cough? Colds are manifested in the form of general weakness, fever, headache, runny nose, cough, shortness of breath due to blockage of the nasal passages, trachea and bronchi by products of an inflammatory reaction. These symptoms are successfully removed by Trialgin at the very beginning of colds. The mechanism of action of the main active ingredient of the drug paracetamol is due to inhibition of the synthesis of prostaglandins and other mediators of pain, thermoregulation and inflammation, mainly in the central nervous system. Caffeine has a moderate psychostimulant effect, temporarily relieves the symptoms of fatigue and drowsiness. Due to the combination of central and peripheral action on the heart and blood vessels, it has an ambiguous effect on the CCC: the coronary vessels, as a rule, expand, and the vessels of the brain become toned, blood pressure rises slightly (more often with initial hypotension). Caffeine increases basal metabolism, has a moderate myotropic antispasmodic effect (expands the bronchi, bile ducts), stimulates the secretion of the gastric glands, slightly increases diuresis. The pharmacological properties of caffeine are due to its competitive antagonism with adenosine at the level of A1 adenosine receptors and inhibition of PDE activity. Chlorphenamine, blocking histamine H1 receptors, has a desensitizing effect, reduces vascular tissue permeability of the mucous membrane of the upper respiratory tract, and thereby prevents runny nose and cough . Thus, the pharmacological properties of Trialgin are aimed at eliminating the pathogenetic mechanisms for the development of colds and eliminating the most painful symptoms of the disease. The anti-cold effect of Trialgin is manifested in antipyretic and analgesic activity, as well as in the elimination of unpleasant sensations caused in the nasopharynx, due to a sore throat and the appearance of a runny nose. It should be noted that Trialgin is especially effective at the very beginning of the development of colds of various etiologies, thereby removing the first symptoms of the disease and alleviating the patient’s condition. In this case, the patient has the opportunity to immediately go to the pharmacy to purchase and use Trialgin, which allows you to quickly and timely start treatment, since Trialgin does not require a doctor’s prescription and can be freely purchased at a pharmacy. Trialgin is also effective in other diseases: febrile syndrome in infectious diseases; pain syndrome (mild and moderate severity): arthralgia, myalgia, neuralgia, migraine, toothache and headache, algomenorrhea; pain in injuries, burns. sinusitis, rhinorrhea (acute rhinitis, allergic rhinitis). Dosage and administration Inside, 1 tablet 2-3 times a day at intervals of at least 4 hours. The notch on the tablet is intended solely to facilitate patient intake. The maximum single dose for adults and children over 15 years old is 2 tablets, the daily dose is 8 tablets. The duration of admission is not more than 5 days. An increase in the daily dose of the drug or the duration of treatment is possible only under medical supervision. Use during pregnancy and lactation is contraindicated Precautions Avoid excessive consumption of tea, coffee and other products containing methylxanthines. To avoid the hepatotoxic effect of paracetamol, ethanol should not be consumed during the treatment period. With prolonged (more than 1 week) use of the drug, it is necessary to control the pattern of peripheral blood and the functional state of the liver. Contraindications Hypersensitivity, deficiency of glucose-6-phosphate dehydrogenase; hepatic and / or renal failure. Pregnancy, lactation (breastfeeding), age up to 15 years, hypersensitivity to the components of the drug. CompositionTrialgin is produced in the form of tablets. The Trialgin tablet contains active ingredients such as paracetamol 325 mg, caffeine 32.0 mg, chlorphenamine maleate 2.0 mg; also, each tablet contains excipients: corn starch, povidone K-30, purified talc, magnesium stearate, sodium starch glycolate (type A), anhydrous colloidal silicon dioxide, dye Tartrazine Supra (E 102). Overdose Symptoms (due to paracetamol): pallor of the skin, loss of appetite, nausea, vomiting; hepatonecrosis (severity of necrosis due to intoxication directly depends on the degree of overdose). Toxic effects in adults are possible after taking more than 10-15 g of paracetamol: increased activity of hepatic transaminases, increased prothrombin time (12-48 hours after ingestion); advanced clinical liver damage manifests itself in 1-6 days. Rarely, liver failure develops at lightning speed and may be complicated by renal failure (tubular necrosis). Side effects Allergic reactions (skin rash, itching, urticaria, angioedema), nausea, epigastric pain. Midraz, paresis of accommodation, increased intraocular pressure, dryness of the mucous membrane of the mouth, nose, throat; urinary retention. With prolonged use in high doses – hepatotoxic effect, hemolytic or aplastic anemia, methemoglobinemia, thrombocytopenia, agranulocytosis, pancytopenia; nephrotoxicity (renal colic, glucosuria, interstitial nephritis, papillary necrosis). Buy Trialgin tablets 325mg/32mg/2mg No. 10×1 Price for Trialgin tablets 325mg/32mg/2mg No. 10×1