Thiogamma 600 tablets p/o 600mg №10×6

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Thiogamma 600 tabl.coated area 600mg in a blister in pack No. 10×6
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Coated tablets are light yellow in color with patches of varying intensity of white and yellow, oblong, biconvex, with risks on both sides; in cross section, the core is light yellow. The main active ingredient Thioctic acid Release form Tablets, coated with a light yellow color with patches of varying intensity of white and yellow, oblong, biconvex, with risks on both sides; in cross section, the core is light yellow. 1 tab. thioctic acid 600 mg Excipients: hypromellose – 25 mg, colloidal silicon dioxide – 25 mg, microcrystalline cellulose – 49 mg, lactose monohydrate – 49 mg, croscarmellose sodium – 16 mg, talc – 36.364 mg, simethicone (dimethicone and colloidal silicon dioxide in ratio 94:6) – 3.636 mg, magnesium stearate – 16 mg. Shell composition: macrogol 6000 – 0.6 mg, hypromellose – 2.8 mg, talc – 2 mg, sodium lauryl sulfate – 0.025 mg. 10 pieces. – blisters (6) – packs of cardboard. Patients with rare hereditary fructose intolerance, glucose / galactose malabsorption syndrome or glucose-isomaltase deficiency should not take Thiogamma®. Patients with diabetes mellitus during the period of treatment with Thiogamma®, especially at the beginning of therapy, need to monitor blood glucose levels. In some cases, it may be necessary to adjust the dose of insulin or oral hypoglycemic drug in order to avoid the development of hypoglycemia. Patients taking Thiogamma® should refrain from drinking alcohol. Alcohol consumption during therapy with Thiogamma® reduces the therapeutic effect and is a risk factor contributing to the development and progression of neuropathy. 1 tablet of Thiogamma® 600 mg contains less than 0.0041 XE. Influence on the ability to drive vehicles and control mechanisms Taking the drug Thiogamma® does not affect the ability to drive vehicles and work with other mechanisms. Pharmacological action Metabolic drug. Thioctic (α-lipoic) acid is an endogenous antioxidant (binds free radicals), is synthesized in the body during oxidative decarboxylation of alpha-keto acids. As a coenzyme of mitochondrial multienzyme complexes, it participates in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. It helps to reduce the concentration of glucose in the blood and increase the content of glycogen in the liver, as well as overcoming insulin resistance. Participates in the regulation of lipid and carbohydrate metabolism, affects the metabolism of cholesterol, improves liver function, has a detoxifying effect in case of poisoning with salts of heavy metals and other intoxications. It has hepatoprotective, hypolipidemic, hypocholesterolemic and hypoglycemic effects. Improves the trophism of neurons. In diabetes mellitus, thioctic acid improves endoneural blood flow, increases the content of glutathione to a physiological value, which as a result leads to an improvement in the functional state of peripheral nerve fibers in diabetic polyneuropathy. Pharmacokinetics Absorption After oral administration, thioctic acid is rapidly and almost completely absorbed from the gastrointestinal tract. When taken simultaneously with food, absorption decreases. The time to reach Cmax (4 μg / ml) is about 30 minutes. Bioavailability – 30-60% due to the effect of “first pass” through the liver. Metabolism Metabolized in the liver by side chain oxidation and conjugation. Withdrawal Thioctic acid and its metabolites are excreted by the kidneys (80-90%), in a small amount – unchanged. T1 / 2 is 25 minutes. Indications for use – diabetic polyneuropathy; – alcoholic polyneuropathy. Dosage and administration Assign inside 600 mg (1 tab.) 1 time / day. Tablets are taken on an empty stomach, without chewing, with a small amount of liquid. The duration of the course of treatment is 30-60 days, depending on the severity of the disease. It is possible to repeat the course of treatment 2-3 times a year. Use during pregnancy and lactation The use of the drug Thiogamma® is contraindicated during pregnancy and lactation (breastfeeding). Interaction with other drugs Thioctic acid enhances the anti-inflammatory effect of GCS. With the simultaneous appointment of thioctic acid and cisplatin, there is a decrease in the effectiveness of cisplatin. Thioctic acid binds metals, so it should not be administered simultaneously with drugs containing metals (for example, iron, magnesium, calcium preparations) – the interval between doses should be at least 2 hours. With the simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs, their effect may intensify. Ethanol and its metabolites weaken the effect of thioctic acid. Contraindications – pregnancy; – lactation period (breastfeeding); — children’s age up to 18 years; – hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption; – hypersensitivity to thioctic acid or other components of the drug. Composition 1 tab. thioctic acid 600 mg Excipients: hypromellose – 25 mg, colloidal silicon dioxide – 25 mg, microcrystalline cellulose – 49 mg, lactose monohydrate – 49 mg, croscarmellose sodium – 16 mg, talc – 36.364 mg, simethicone (dimethicone and colloidal silicon dioxide in ratio 94:6) – 3.636 mg, magnesium stearate – 16 mg. Shell composition: macrogol 6000 – 0.6 mg, hypromellose – 2.8 mg, talc – 2 mg, sodium lauryl sulfate – 0.025 mg. Overdose Symptoms: nausea, vomiting, headache. In the case of taking from 10 to 40 g of thioctic acid in combination with alcohol, there have been cases of intoxication, up to death. Symptoms of acute overdose: psychomotor agitation or clouding of consciousness, as a rule, with the subsequent development of generalized convulsions and the formation of lactic acidosis. Cases of hypoglycemia, shock, rhabdomyolysis, hemolysis, disseminated intravascular coagulation, bone marrow suppression, and multiple organ failure have also been described. Treatment: carry out symptomatic therapy. There is no specific antidote. Side effects The frequency of adverse reactions is given according to the WHO classification: Very often in more than 1 in 10 people treated Often in less than 1 in 10, but in more than 1 in 100 people treated Uncommon in less than 1 in 100, but more less than 1 in 1000 people treated Rare less than 1 in 1000, but more than 1 in 10,000 people treated Very rare less than 1 in 10,000, including isolated cases Very rarely (<1/10,000) develop the following side effects effects: From the digestive system: nausea, vomiting, abdominal pain, diarrhea. Allergic reactions: systemic reactions (up to the development of anaphylactic shock), skin rash, urticaria, itching. From the side of the central nervous system: a change or violation of taste sensations. On the part of the endocrine system: due to the improvement in the absorption of glucose, a decrease in the concentration of glucose in the blood is possible. In this case, symptoms of hypoglycemia may occur - dizziness, increased sweating, headache, visual disturbances. Storage conditions The drug should be stored in a dry place, out of the reach of children, at a temperature not exceeding 25°C. Buy Thiogamma 600 tablets p/o 600mg №10x6 Price for Thiogamma 600 tablets p/o 600mg №10x6