Suprastin tablets 25mg №10×2

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Suprastin tablets 25 mg in bl. in pack. No. 10х2
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Tablets of white or grayish-white color, in the form of a disk with a chamfer, with an engraving “SUPRASTIN” on one side and a notch on the other, odorless or almost odorless. The main active ingredient Chloropyramine Release form Tablets are white or grayish-white in color, in the form of a disk with a chamfer, engraved “SUPRASTIN” on one side and a risk mark on the other, odorless or almost odorless. 1 tab. chloropyramine hydrochloride 25 mg Excipients: stearic acid, gelatin, sodium carboxymethyl starch (type A), talc, potato starch, lactose monohydrate – 116 mg. 10 pieces. – blisters (2) – packs of cardboard. 20 pcs. – blisters (1) – packs of cardboard. 20 pcs. – brown glass bottles with PE caps (1) – cardboard packs. The solution for intravenous and intramuscular administration is clear, colorless, aqueous, with a slight characteristic odor. 1 amp. chloropyramine hydrochloride 20 mg Excipients: water for injection – up to 1 ml. 1 ml – ampoules with a break point and a dark red code ring (5) – blister packs (1) – cardboard packs. 1 ml – ampoules with a break point and a dark red code ring (5) – blister packs (2) – cardboard packs. Dosage 25mg in bl. in pack. No. 10×2 Special instructions When combined with ototoxic drugs, Suprastin® may mask early signs of ototoxicity. Diseases of the liver and kidneys may require a change (reduction) in the dose of the drug, and therefore the patient should inform the doctor about the presence of liver or kidney disease. Taking the drug at night can increase the symptoms of reflux esophagitis. Suprastin® can enhance the effect of ethanol on the central nervous system, and therefore, while taking the drug Suprastin®, you should avoid drinking alcoholic beverages. Prolonged use of antihistamines can lead to disorders of the hematopoietic system (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia). If during long-term use there is an inexplicable increase in body temperature, laryngitis, pallor of the skin, jaundice, the formation of ulcers in the mouth, the appearance of hematomas, unusual and prolonged bleeding, it is necessary to conduct a clinical blood test to determine the number of formed elements. If the results of the analysis indicate a change in the blood count, the drug is stopped. Influence on the ability to drive vehicles and control mechanisms The drug, especially in the initial period of treatment, can cause drowsiness, fatigue and dizziness. Therefore, in the initial period, the duration of which is determined individually, it is prohibited to drive vehicles or perform work associated with an increased risk of accidents. After that, the degree of restriction on driving vehicles and working with mechanisms, the doctor must determine for each patient individually. Pharmacological action Antiallergic drug. Histamine H1 receptor blocker. Chloropyramine hydrochloride, a chlorinated analog of tripelenamine (pyribenzamine), is a classic antihistamine belonging to the group of ethylenediamine antihistamines. It has an antihistamine and m-anticholinergic effect, has an antiemetic effect, moderate antispasmodic and peripheral anticholinergic activity. The therapeutic effect of chlorpyramine develops within 15-30 minutes after ingestion, reaches a maximum within the first hour after ingestion and lasts at least 3-6 hours. Distribution and metabolism It is well distributed in the body, including the CNS. Intensively metabolized in the liver. Excretion Excreted mainly by the kidneys. Pharmacokinetics in special clinical situations In children, the excretion of the drug is faster than in adults. Indications for use – urticaria; – serum sickness; – seasonal and year-round allergic rhinitis; – conjunctivitis; – contact dermatitis; – skin itching; – acute and chronic eczema; – atopic dermatitis; – food and drug allergies; – allergic reactions to insect bites; – angioedema (Quincke’s edema) – for solution; – angioedema (Quincke’s edema) – as an aid – for tablets. Dosage and administration Tablets Tablets should be taken orally during meals, without chewing and drinking plenty of water. Adults are prescribed 25 mg (1 tab.) 3-4 times / day (75-100 mg / day). Children aged 3 to 6 years are prescribed 1/2 tab. (12.5 mg) 2 times / day; children aged 6 to 14 years – 1/2 tab. (12.5 mg) 2-3 times / day. The dose can be gradually increased in the absence of side effects in the patient, but the maximum dose should not exceed 2 mg/kg of body weight. The duration of the course of treatment depends on the symptoms of the disease, its duration and course. Solution for i / m and / in the introduction / in the introduction is used only in acute severe cases under the supervision of a physician. For adults, the recommended daily dose is 1-2 ml (1-2 ampoules) intramuscularly. In severe allergies, treatment should begin with a cautious slow intravenous injection, and then continue with intramuscular injections or oral administration of the drug. Special groups of patients Elderly, malnourished patients: the use of the drug Suprastin® requires special care, because. in these patients, antihistamines often cause side effects (dizziness, drowsiness). Patients with impaired liver function: a dose reduction may be required due to a decrease in the metabolism of the active component of the drug in liver diseases. Patients with impaired renal function: it may be necessary to change the regimen of the drug and reduce the dose due to the fact that the active ingredient is mainly excreted by the kidneys. Use during pregnancy and lactation There have been no adequate and well-controlled studies of the use of antihistamines during pregnancy. Therefore, the use of the drug in pregnant women (especially in the first trimester and in the last month of pregnancy) is possible only if the potential benefit to the mother outweighs the possible risk to the fetus. If necessary, the use of the drug during lactation should stop breastfeeding. Precautions The drug should be used with caution in case of impaired liver function. The drug should be used with caution in case of impaired renal function. The drug is contraindicated for use in newborns (including preterm infants). The drug in the form of tablets is contraindicated in children under 3 years of age. Elderly, malnourished patients: the use of the drug Suprastin® requires special care, because. in these patients, antihistamines are more likely to cause side effects (dizziness, drowsiness). Interaction with other drugs The drug enhances the effect of barbiturates, M-anticholinergics, opioid analgesics. MAO inhibitors can enhance and prolong the anticholinergic effect of chloropyramine. When combined with ototoxic drugs, Suprastin may mask signs of ototoxicity. Antihistamines can distort the results of skin allergy tests, therefore, a few days before the planned test, the use of drugs in this group should be stopped. Contraindications – acute attack of bronchial asthma; – pregnancy; – lactation (breastfeeding); – children’s age up to 3 years (for tablets); – lactase deficiency, lactose intolerance, glucose-galactose malabsorption syndrome (for tablets, as 1 tablet contains 116 mg of lactose monohydrate); – newborn babies (term and premature); – Hypersensitivity to the components of the drug. With caution, the drug should be used for angle-closure glaucoma, in patients with urinary retention and prostatic hyperplasia, with impaired liver and / or kidney function, cardiovascular diseases, and in elderly patients. Composition 1 tab. chloropyramine hydrochloride 25 mg Excipients: stearic acid, gelatin, sodium carboxymethyl starch (type A), talc, potato starch, lactose monohydrate – 116 mg. 10 pieces. – blisters (2) – packs of cardboard. 20 pcs. – blisters (1) – packs of cardboard. 20 pcs. – brown glass bottles with PE caps (1) – cardboard packs. Overdose Symptoms: hallucinations, anxiety, ataxia, incoordination, athetosis, convulsions; in young children – agitation, anxiety, dry mouth, fixed dilated pupils, reddening of the face, sinus tachycardia, urinary retention, fever, coma; in adults – fever and redness of the face are observed intermittently, after a period of excitement, convulsions and postconvulsive depression, coma follow. Treatment: up to 12 hours after taking the drug – gastric lavage (it should be borne in mind that the emptying of the stomach is prevented by the anticholinergic effect of the drug), the appointment of activated charcoal, control of blood pressure and respiration parameters, symptomatic therapy, if necessary – resuscitation. The specific antidote is unknown. Side effects Side effects occur, as a rule, extremely rarely, are temporary and disappear after discontinuation of the drug. On the part of the hematopoietic system: very rarely – leukopenia, agranulocytosis, hemolytic anemia and other changes in the cellular composition of the blood. From the side of the central nervous system: drowsiness, fatigue, dizziness, nervous excitement, tremor, headache, euphoria, convulsions, encephalopathy. On the part of the organ of vision: blurred vision, glaucoma, increased intraocular pressure. From the side of the cardiovascular system: a decrease in blood pressure, tachycardia, arrhythmia (the direct relationship of these side effects with the drug has not always been established). From the digestive system: abdominal discomfort, dry mouth, nausea, vomiting, diarrhea, constipation, loss or increase in appetite, epigastric pain. From the urinary system: difficulty urinating, urinary retention. From the musculoskeletal system: muscle weakness. Other: photosensitivity, allergic reactions. If any of the above effects occur, the patient should stop taking the drug and consult a doctor immediately. Storage conditions The drug should be stored out of the reach of children at a temperature of 15 ° to 25 ° C. Buy Suprastin tablets 25 mg No. 10×2 Price for Suprastin tablets 25 mg No. 10×2