Povidone-iodine ointment 100mg/g 20g №1

Name:
Povidone-iodine ointment 20g CompositionEach tube (20g) contains: active ingredient: iodine povidone – 2g; excipients: macrogol 4000, sodium hydroxide, purified water, macrogol 400. 1 gram of ointment contains iodine povidone 100 mg/g.
Description:
Ointment of brown color with a slight smell of iodine of a homogeneous consistency. Pharmacotherapeutic group Dermatotropic agents. Iodine-containing antiseptic preparations. ATX code: D08AG02. Pharmacological properties Pharmacodynamics Povidone-iodine is a complex of iodine and a polymer of polyvinylpyrrolidone, from which iodine is released for some time after the application of the drug and a constant concentration of active free iodine is provided. Free iodine (I2) has a strong bactericidal effect. In in vitro studies, it quickly destroys bacteria, viruses, fungi and some protozoa. In vitro, most microorganisms die within less than one minute, with the greatest bactericidal effect observed during the first 15-30 seconds. Drug resistance is unknown. Pharmacokinetics Absorption Systemic absorption of iodine after topical application in healthy subjects is negligible. Povidone (PVP) Absorption and even more so renal excretion of povidone depends on its molecular weight. Since its molecular weight is in the range of 35,000 – 50,000, a delay should be expected. Iodine Absorption of iodized povidone or iodides is similar to absorption of iodine from other sources. Excretion is predominantly by the kidneys. Indications for use for local treatment of wounds or small cuts and prevention of infection of small burns; in the complex therapy of fungal or bacterial infections of the skin, infected bedsores and trophic ulcers. Contraindications hypersensitivity to iodine and other components of the drug; endemic goiter, Hashimoto’s thyroiditis, thyrotoxicosis, thyroid adenoma; Dühring’s herpetiform dermatitis; before and after radioactive iodine therapy or scintigraphy; neonatal period; children’s age up to 2 years; pregnancy (II-III trimester) and lactation. Method of application and dosesFor topical use only. Dosage The drug is used topically and topically. The ointment is applied in a thin layer, without rubbing, on the lesion. Multiplicity of application of the ointment 1-2 times a day. The duration of therapy is 7-14 days. The affected area must be cleaned and dried in advance, before applying the ointment, since its effectiveness in the presence of various organic substances, such as blood and pus, is reduced, since they oxidize and bind active iodine. In the treatment of infected wounds, bedsores and trophic ulcers, after applying the ointment, if necessary, you can use a gauze bandage. Side effects Adverse reactions are listed according to the classification of undesirable side effects in accordance with the damage to organs and organ systems and the frequency of development: very often (? 1/10), often (? 1/100 to < 1/10), infrequently (? 1/1000 to < 1/100), rare (? 1/10000 to < 1/1000), very rare (< 1/10000), frequency not known (cannot be estimated from the available data). Immune system disorders: rarely - hypersensitivity, very rarely - anaphylactic reactions. Endocrine disorders: very rarely - hyperthyroidism (sometimes tachycardia or anxiety), the frequency is not known - hypothyroidism. Metabolic and nutritional disorders: the frequency is not known - the absorption of electrolytes, metabolic acidosis. Skin and subcutaneous tissue disorders: rarely - contact dermatitis (eg, erythema, small blisters and itching), very rarely - angioedema. Renal and urinary tract disorders: frequency not known - acute renal failure, impaired osmolarity. Injuries, intoxications and complications of procedures: the frequency is not known - chemical burns of the skin. Interaction with other drugs The combined use of Povidone-iodine ointment and enzyme preparations used in the treatment of wound surfaces leads to a decrease in the effectiveness of both drugs. Simultaneous or sequential use of medicines containing iodinated povidone and antiseptics containing octenidine may cause temporary darkening of the skin at the site of use. Attention! The oxidative properties of iodinated povidone may interfere with some diagnostic tests, resulting in false positive results of tests to determine urinary or fecal hemoglobin, urinary glucose levels in patients using iodinated povidone preparations. Against the background of the use of preparations containing iodinated povidone, the absorption of thyroid iodine may be reduced, which may distort the results of diagnostic studies using radioactive iodine preparations and reduce the effectiveness of thyroid iodine therapy. Thyroid scintigraphy may be recommended no earlier than 1-2 weeks after completion of treatment with drugs containing iodinated povidone. Pharmaceutically incompatible with disinfectants containing mercury or oxidizing agents, alkali solutions (there is an accelerated destruction of the iodine-polyvinylpyrrolidone complex). Weakens the effect of antitumor therapy with radioactive iodine, the effect of thyreostatic drugs from the group of thioamides (thiamazole, propyl-thiouracil). When used simultaneously with potassium iodide and amiodarone, it increases the risk of developing iodism and thyroid dysfunction. In the presence of blood, the bactericidal effect is reduced. It should not be used simultaneously with drugs containing the following ingredients: chlorhexidine, tannic acid, silver. Precautions Povidone-iodine ointment is intended for topical use. Avoid contact with eyes. Prolonged use may cause skin irritation, rarely ? serious skin reactions. If local irritation or hypersensitivity occurs, treatment should be discontinued. Do not reheat before use. Keep out of the reach of children. When used on large areas of the skin and during long-term treatment - for example, when treating burns or wounds - a significant amount of iodine can be absorbed and cause hyperthyroidism. It is recommended to avoid applying the ointment to skin areas whose total area exceeds 10 percent of the body surface area and / or apply the ointment for more than 14 days. The patient's condition should be monitored for symptoms of iodism, hyperthyroidism, thyroid function, especially in cases of using Povidone-iodine ointment on large surfaces and / or for a long time. Use in patients with impaired liver function, chronic renal failure requires increased caution. Povidone-iodine ointment is not recommended for use in patients receiving lithium therapy. Caution in the appointment should be observed in persons with impaired thyroid function. The use of the ointment in this group of patients should be as limited as possible and carried out only under conditions of careful monitoring of thyroid function. Use in pediatrics. The use of ointment in newborns and children under 2 years of age is contraindicated. Impact on laboratory parameters. Against the background of treatment with ointment, it is possible to obtain false results when determining the level of thyroid hormones and protein-bound iodine in the blood plasma. Application during pregnancy and lactationAtomic iodine and iodide ion easily penetrate the placental barrier, are excreted in breast milk and can cause the development of goiter in a child. The use of ointment during pregnancy (from the 3rd month) is contraindicated. If necessary, its use during lactation should provide for the rejection of breastfeeding for the entire period of treatment and within 1 week after its completion. Influence on the ability to drive vehicles and control mechanisms Povidone-iodine does not affect the ability to drive a vehicle and engage in any potentially hazardous activities. Overdose Acute iodine intoxication can have the following effects: metallic taste in the mouth, salivation, burning, pain in the mouth, throat; eye irritation and swelling; skin diseases; abdominal fullness, diarrhea; impaired renal function, anuria; heart failure; swelling of the glottis, concomitant asphyxia and pulmonary edema, metabolic acidosis and hypernatremia. Treatment. Symptomatic therapy, supportive therapy is used. Particular attention is paid to the correction of electrolyte disorders, normalization of kidney and thyroid function. Upakovka20 g in aluminum tubes. Each tube, together with the leaflet, is placed in a cardboard box (packaging No. 1). Storage conditions At a temperature not higher than 25 °C. Keep out of the reach of children. Shelf life 2 years. Do not use the medicine after the expiration date. Conditions for dispensing from pharmaciesWithout a prescription. Buy Povidone-iodine ointment 100mg/g 20g No. 1 Price for Povidone-iodine ointment 100mg/g 20g No. 1