Nasoferon nasal drops 100,000 IU/ml 5ml №1

Name:
Nazoferon drops called (water) 100 000 IU / ml in a vial. 5ml №1
Description:
Transparent colorless liquid. NAZOFERON is a recombinant human interferon alpha-2b. The main active ingredient is interferon alfa-2b recombinant human 100,000 IU/ml; Release form Nasal drops (water) Dosage 5 ml Pharmacological action NAZOFERON contains recombinant human interferon alfa 2b. Interferon alfa-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The biological effect of interferon is characterized by the following effects: antiviral – inhibits the replication of viruses (adenoviruses, influenza viruses, etc.) due to the inhibitory effect on the processes of transcription and translation; antiproliferative – inhibits cell reproduction (most DNA – and RNA-containing viruses). Interferon initiates the synthesis of a specific enzyme – protein kinase, which prevents translation due to the phosphorylation of one of the initiating factors of this process; activates a specific ribonuclease, which damages the messenger RNA of the virus. The effects of interferon also include: stimulation of the production of other cytokines, induction of specific enzymes, inhibition of cell proliferation, immunomodulation (increased phagocytic activity of macrophages and specific cytotoxicity of lymphocytes in relation to target cells). PharmacokineticsPharmacokinetic studies have not been conducted due to the low bioavailability of recombinant protein preparations for intranasal use, as a result of which the concentration of the active substance achieved in the blood when using the drug at recommended doses is significantly below the detection limit and has no clinical significance. Indications for use Prevention and treatment of acute respiratory viral infections in adults and children older than 1 month. Method of administration and doses At the first signs of ARVI disease (for 5 days) Children from 1 month to 1 year – 1 drop in each nasal passage 5 times a day (single dose – 8000 IU, daily dose – 40000 IU); Children from 1 to 3 years old – 2 drops 3-4 times a day (single dose – 16000 IU, daily dose – 48000-64000 IU); Children from 3 to 14 years old – 2 drops 4-5 times a day (single dose – 16000 IU, daily dose – 64000-80000 IU); Adults – 3 drops 5-6 times a day (single dose – 24,000 IU, daily dose – 120,000-144,000 IU). For the prevention of respiratory viral infections In contact with the patient and hypothermia – in accordance with the age dosage 2 times a day for 5-7 days. If necessary, preventive courses are repeated. With a single contact, one instillation is sufficient. With a seasonal increase in the incidence – in accordance with the age dosage once in the morning with an interval of 1-2 days. Precautions The drug is administered into each nasal passage, according to the method of application and dosing. Before using the drug, it is necessary to take a position lying on your back or sitting, slightly tilt your head back and turn towards the nasal passage into which the drops will be instilled and, without touching the inner walls of the nose with the dropper of the bottle, drip the drug. Immediately after instillation, to evenly distribute the drug over the nasal mucosa, it is recommended to massage the wings of the nose with your fingers for several minutes from the outside. The use of drops for children is carried out under the supervision of adults. Patients with impaired liver and kidney function, as well as elderly patients, dosing adjustment is not required. Interaction with other drugs The simultaneous use of intranasal vasoconstrictor drugs is not recommended, since they contribute to the dryness of the nasal mucosa. Contraindications Hypersensitivity to interferon alfa-2b and other components that make up the drug, a history of severe forms of allergic diseases. The period of pregnancy or lactation. Active ingredient: recombinant human interferon alfa-2b 100,000 IU/ml; excipients: trometamol, trometamol hydrochloride, hypromelose, disodium edetate, lysine hydrochloride, potassium chloride, methyl parahydroxybenzoate (E 218), water for injection. 1 ml of the drug contains 23 drops. Overdose Not studied Side effectsIn isolated cases – a rash on the skin. In case of adverse reactions, you should consult your doctor. Storage conditions Store in a place protected from light at a temperature of 2 ºС to 8 ºС. Keep out of the reach of children! Best before date. 2 years. Shelf life after opening the vial, if stored at a temperature of 2 ºС to 8 ºС (in the refrigerator) – 10 days. Do not use the drug after the expiration date indicated on the package. Buy Nasoferon nasal drops 100,000 IU/ml 5ml No. 1 Price for Nasoferon nasal drops 100,000 IU/ml 5 ml No. 1