Lyziret tablets 20mg/12.5mg №10×3

Name Lyziret tabl. Expands peripheral vessels, which facilitates the work of the heart and lowers blood pressure (BP). Normalization of blood pressure avoids such consequences of arterial hypertension as myocardial infarction and stroke. The main active substance Lisinopril + hydrochlorothiazide Form of release tablets Dosage 20 mg + 12.5 mg Indications for use Treatment of mild to moderate arterial hypertension in patients whose condition is already adequately controlled by the simultaneous administration of lisinopril and hydrochlorothiazide in the same doses as in the drug Lyziret. Dosage and administration It is taken once a day, preferably at the same time, regardless of the meal. Essential hypertension: The usual dose of Lyziret is 10 mg/12.5 mg per day. In the absence of the desired effect, the dose may be increased to 20 mg / 12.5 mg 1 time per day. Renal failure: in patients with a creatinine clearance of 30-80 ml / min, the drug can be used only after titration of the dose of the individual components of the drug. The recommended initial dose of lisinopril for uncomplicated renal failure is 5-10 mg. Prior Diuretic Therapy: Diuretics should be discontinued 2-3 days prior to initiation of treatment with Lyziret. Elderly patients: dose adjustment in the absence of impaired renal function is not required. Children and adolescents (<18 years): The safety and efficacy of Lyziret in children has not been established. Use during pregnancy and lactation Liziret is not recommended for use in the first trimester of pregnancy. If pregnancy is planned or confirmed, the drug is canceled, an alternative treatment is prescribed. Contraindicated in the second, third trimesters of pregnancy (toxic effect on the fetus) and during breastfeeding. If necessary, admission during lactation - breastfeeding stops. Interaction with other drugs When prescribing Lyziret, be sure to inform your doctor if you are taking any of the following drugs Lithium preparations: the toxic effect of lithium may be increased. Potassium-sparing diuretics, potassium supplements and potassium-containing salt substitutes: possible increase in blood potassium levels. Regular monitoring of potassium levels is recommended. Antiarrhythmic drugs (quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide), neuroleptics (thioridazine, chlorpromazine, levomepromazine, trifluoperazine, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol), and other drugs (bepridil, cisapride, difemanil, intravenous erythromycin, halofantrine, mizolastine, pentamidine, terfenadine, intravenous vincamine), sotalol, whose action depends on the level of potassium in the blood: are used with caution. Recommended control of potassium in the blood, control of the ECG. Tricyclic antidepressants / neuroleptics / anesthetics: it is possible to increase the hypotensive effect of Lyziret. Salicylates and other NSAIDs (indomethacin, selective COX-2 inhibitors): decrease in the hypotensive and diuretic effect of Lyziret. The combination is used with caution in patients with impaired renal function and elderly patients. Monitoring of kidney function is recommended. Injectable gold preparations: symptoms such as facial flushing, hot flashes, nausea, dizziness, lowering blood pressure, incl. expressed. Ephedrine, norepinephrine, epinephrine: may reduce the hypotensive effect of Lyziret. Other antihypertensive drugs: mutual enhancement of the hypotensive effect. Medicines for diabetes: their ability to lower sugar levels is enhanced. Regular monitoring of blood glucose levels is recommended. Amphotericin B (parenteral), carbenoxolone, corticosteroids, corticotropin (ACTH), stimulant laxatives, trimethoprim: possible decrease in blood potassium levels. Recommended control of potassium in the blood. Calcium salts and vitamin D: it is possible to reduce the excretion of calcium and increase its level in the blood. It is recommended to control calcium levels. Cardiac glycosides: increased risk of toxic effects of glycosides. Colestipol and colestirami: Co-administration reduces the absorption of hydrochlorothiazide. Lyziret should be taken 1 hour before or 4-6 hours after taking these drugs. Antidepolarizing muscle relaxants (tubocurarine chloride): enhancing their effect. Allopurinol: increased risk of developing renal failure, leukopenia. Cyclosporine: increased risk of kidney failure, possible increase in blood potassium levels. Lovastatin: possible increase in the level of potassium in the blood. Cytostatics, immunosuppressants, procainamide: increased risk of leukopenia. Contraindications Do not take Lyziret in the following cases: a history of hypersensitivity to lisinopril or other ACE inhibitors, hydrochlorothiazide or other thiazides, to any of the excipients of this drug; angioedema (including in the past from the use of ACE inhibitors), hereditary or idiopathic angioedema; diabetes or impaired kidney function and you are being treated with blood pressure medicines containing aliskiren; second and third trimesters of pregnancy and breastfeeding period; severe renal failure (creatinine clearance less than 30 ml / min), anuresis; severe liver failure. Composition Each tablet of Lyziret, a combined drug, contains the active substance - lisinopril 10 mg or 20 mg, diuretic - hydrochlorothiazide - 12.5 mg and excipients: lactose monohydrate, microcrystalline cellulose, mannitol, colloidal anhydrous silicon dioxide, magnesium stearate, for a dosage of 10 mg / 12.5 mg - sunset yellow dye (E 110). It belongs to the group of antihypertensive combined drugs (angiotensin-converting enzyme inhibitor (ACE inhibitor) + diuretic). Overdose If the number of tablets per day that you have taken exceeds the amount recommended by your doctor, or your child has swallowed the tablets, immediately consult a doctor or call an ambulance! An overdose is likely to cause a pronounced decrease in blood pressure, heart rate, stupor, impaired renal function, and a change in blood biochemical parameters. Stop taking the medicine! As a first aid, lay the patient on his back so that the head is lowered and the legs are raised. Control of blood pressure, heart rate. Gastric lavage and antacids are recommended as first aid. Side effects Lyziret, like other ACE inhibitors or diuretics, can cause side effects with varying frequency: Lisinopril: Often (1 in 10-100 cases): dizziness, headache, orthostatic effects, lowering blood pressure, cough, diarrhea, vomiting, allergic rash, impaired renal function. Uncommon (1 in 100 to 1,000 cases): mood changes, balance problems, dizziness (vertigo), sleep disturbance, unusual skin sensations (numbness, tingling, crawling), fast or irregular heartbeat, chest pain, brain or coronary circulation, Raynaud's syndrome, runny nose, itching, sneezing, nasal congestion, sexual dysfunction, fatigue, weakness, visual or auditory hallucinations. Rare (1 in 1,000-10,000 cases): confusion, olfactory disorders, dry mouth, hair loss, gynecomastia, psoriasis, feeling unwell, irritability. Very rare (less than 1 in 10,000 cases): low blood sugar, nervousness, sweating, abdominal pain with or without nausea/vomiting, decreased urine output, difficulty breathing, shortness of breath, chest tightness, sinus pain, symptoms of sinusitis (high fever, headache, fatigue, cough, loss of taste and smell, bad breath, ear pressure), skin rash, pemphigus. Frequency unknown: depression, fainting. Hydrochlorothiazide: Very common (more than 1 in 10 cases): disturbances in water and electrolyte balance; Often (1 in 10-100 cases): decreased platelet count, palpitations, loss of appetite, nausea, vomiting, diarrhea, abdominal pain and cramps, reversible increase in creatinine and urea levels in the blood and urine. Uncommon (1 in 100-1000 cases): decrease in the number of leukocytes, temporary visual impairment, decreased production of tear fluid, worsening myopia, orthostatic hypotension, vasculitis, dyspnea, acute interstitial pneumonia, increased blood amylase levels, pancreatitis, jaundice, allergic skin reactions (itching, erythema, photosensitivity, purpura, urticaria), interstitial nephritis, sexual dysfunction. Rarely (1 in 1,000-10,000 cases): anaphylactic reaction, headache, dizziness, paresthesia, depression, insomnia, rhythm disturbance, constipation. Very rare (less than 1 in 10,000 cases): bone marrow suppression, agranulocytosis, aplastic or hemolytic anemia, pulmonary edema, shock, allergic reaction, toxic epidermal necrolysis, systemic lupus erythematosus, systemic lupus erythematosus-like reactions or reactivation of systemic lupus erythematosus. Frequency not known (cannot be estimated from the available data): hypochloremic alkalosis (may cause hepatic encephalopathy and hepatic coma); hyperuricemia (may trigger a gout attack in asymptomatic patients); decreased glucose tolerance (possible manifestation of latent diabetes mellitus), acute angle-closure glaucoma, acute cholecystitis. If you experience the following side effects, stop taking the medicine and immediately consult a doctor or call an ambulance: swelling of the hands, face, lips, tongue; difficulty breathing; sudden appearance of rashes, lesions, redness, peeling of the skin; sore throat; severe dizziness or weakness; acute pain in the abdomen; irregular or rapid heartbeat; yellowness of the skin or eyes! Storage conditionsStore at a temperature not exceeding 25°C. Keep out of the reach of children. Buy Liziret tablets 20mg/12.5mg No. 10x3