Ketorol gel for 20mg/g 30g №1

Name:
Ketorol gel for nar. 20mg/g in tubes 30g per pack. No. 1
Description:
Homogeneous, with a specific smell transparent or translucent gel. The main active ingredient Ketorolac Release form 30 g or 50 g of gel in a tube of laminated aluminum foil in a cardboard box with instructions for use. Dosage 20 mg/g in tubes 30 g Pharmacodynamics Ketorolac, being a non-steroidal anti-inflammatory drug, has analgesic and anti-inflammatory effects. The mechanism of action at the biochemical level is the inhibition of the cyclooxygenase enzyme, mainly in peripheral tissues, which results in inhibition of the biosynthesis of prostaglandins – modulators of pain sensitivity, thermoregulation and inflammation. Pharmacokinetics Absorption: Systemic absorption of the drug when applied topically is negligible, in pharmacokinetic studies of the absorption of ketorolac when applied topically, Cmax was observed after 1-1.5 hours and amounted to 0.17-0.8 μg / ml. In a study in 10 healthy volunteers after topical application for 24 hours, Cmax was 0.20, 0.18, and 0.82 µg/mL for TD-A, TD-B, and TD-C vehicles, respectively (TD-A (microporous membrane/acrylic adhesive ), TD-B (microporous membrane/silicone adhesive) and TD-C (microporous membrane) AUC for TD-C > TD-A > TD-B, half-life was 6.6-9.7 h. depth of 3-4 mm, it penetrates into deeper tissues through the bloodstream.In vitro studies have shown that in subcutaneous tissues with topical application of ketorolac tromethamine accumulates in concentrations close to therapeutic concentrations observed with systemic use of the drug.Metabolism: Although studies of the metabolism of ketorolac when applied topically, studies of the metabolism of the drug with its systemic use suggest that ketorolac is metabolized in the liver mainly with the formation of conjugated forms of glucuro new acid, which are excreted through the kidneys. Metabolites do not have analgesic activity. The half-life of the drug is an average of 5 hours, about 92% of the dose taken is excreted in the urine. Indications for use Local treatment of pain and inflammation with minor injuries of soft tissues (muscles and ligaments), gonarthrosis and pain in the lower back. Dosage and administration Before applying the gel, it is recommended to rinse and dry the application area. Wash your hands before and after applying the drug. Apply to the affected area on the fingertip 3-4 times daily, or as directed by a physician. Gently rub the drug into the skin. Do not apply the gel to the eyes, mucous membranes and open wounds. The patient should be advised to avoid wearing tight clothing. Do not use with an occlusive dressing. If the condition worsens, it is recommended to stop using the drug and consult a doctor. It is not recommended to use more than 10 days. If there is no effect when using the drug for 10 days, it is recommended to consult a doctor to review the therapy. Use during pregnancy and lactation The efficacy and safety of the drug in pregnant and lactating women have not been confirmed. Since ketorolac has a high protein affinity (98%), the use of ketorolac gel during pregnancy and lactation is not recommended. Elderly patients: due to the increased sensitivity of elderly patients to side effects, the recommended dose should not be exceeded when using the drug. Precautions Do not apply the gel to the eyes, mucous membranes, skin areas with open lesions, dermatoses or infectious lesions. Do not touch sensitive areas of the skin during the procedure and before cleansing the hands from the remnants of the drug. In some patients, the drug may cause allergic-type reactions. If irritation or inflammation occurs at the site of application, the use of the drug should be discontinued. In patients with a history of allergic reactions, ketorolac can cause the development of severe anaphylactic reactions; there have been cases of complications of this kind in patients who have not previously experienced allergic reactions. There is a possibility of cross-hypersensitivity with acetylsalicylic acid, phenylacetylic acid and other NSAIDs. Ketorolac gel should be used with caution in surgical patients with a known tendency to bleed or who are receiving other drugs that prolong bleeding time. All topical NSAIDs can delay wound healing. Information about excipients: This medicinal product contains dimethyl sulfoxide and propylene glycol, which may cause skin irritation. The medicinal product contains sodium methyl and propyl hydroxybenzoate, which may cause allergic reactions, including delayed ones. Interaction with other drugs Due to the slight systemic absorption of ketorolac when applied topically, interaction with other drugs is unlikely. Contraindications Hypersensitivity to ketorolac, aspirin and other NSAIDs, nasal polyp syndrome, bronchospasm, angioedema after aspirin use. History of gastric or duodenal ulcer, bleeding or perforation. Pregnancy and lactation. Age under 18 years (no experience of use). Ketorolac tromethamine should not be used for obstetric pain relief. Do not apply to the eyes, mucous membranes and open wounds. Composition Each 1 g of gel contains 20 mg of ketorolac tromethamine, as well as excipients: propylene glycol (E1520), dimethyl sulfoxide, carbomer 974 R, sodium methylhydroxybenzoate (E219), sodium propylhydroxybenzoate (E217), tromethamine, dreamon ind flavor (diethyl phthalate, benzyl salicylate, dihydromyrcenol, linalool, linalyl acetate), ethanol, glycerin (E422), purified water. Overdose Cases of overdose with topical application are not described. If the gel is accidentally swallowed, discomfort and pain in the abdomen, as well as other symptoms of irritation of the gastrointestinal tract, may occur. In a study in healthy volunteers, oral ketorolac at a dose of 360 mg/day in 4 doses for 5 days caused the development of a peptic ulcer, which resolved after discontinuation of the drug. A single dose of the drug at a dose of 200 mg was not accompanied by the development of any significant disorders. If you suspect that you have swallowed the gel, you should seek medical attention. Symptomatic and supportive therapy is recommended. Dialysis with an overdose of ketorolac is not effective. Side effects Topical application of ketorolac is usually well tolerated, local reactions (irritation, inflammation, erythema, dermatitis) may occur that do not require discontinuation of therapy. If the gel is accidentally swallowed, discomfort and pain in the abdomen, as well as other symptoms of irritation of the gastrointestinal tract, may occur. Storage conditionsStore at temperatures up to 25°C. Keep out of the reach of children. Buy Ketorol gel for 20mg/g 30g №1 Price for Ketorol gel for 20mg/g 30g №1 Instructions for use for Ketorol gel for 20mg/g 30g №1