Indapen retard prolonged-release tablets p/o 1.5mg №15×2

Name Indapen retard prolong tablets po 1.5 mg in bl. in pack. No. 15×2 The main active ingredient indapamide Release form Tablets Dosage 1.5 mg Special instructions Use with caution in patients with diabetes mellitus (glucose control is necessary, especially in the presence of hypokalemia), gout (an increase in the number of attacks is possible), in patients with a history of allergic reactions to derivatives sulfonamides. During treatment, it is necessary to control the level of electrolytes in the blood plasma (potassium, sodium, calcium). Indications for use Arterial hypertension; sodium and water retention in chronic heart failure. Dosage and administration Take orally 2.5 mg 1 time / day (in the morning). With insufficient severity of the hypotensive effect after 2 weeks of treatment, the dose is increased to 5-7.5 mg / day. The maximum daily dose is 10 mg divided into 2 doses (in the morning). Use during pregnancy and lactation Adequate and well-controlled studies of the safety of the use of indapamide during pregnancy and lactation have not been conducted. Use in this category of patients is not recommended. Interaction with other drugs With the simultaneous use of corticosteroids, tetracosactide for systemic use, the hypotensive effect decreases due to the retention of water and sodium ions under the influence of corticosteroids. With simultaneous use with ACE inhibitors, the risk of developing hyponatremia increases. With simultaneous use with NSAIDs (for systemic use), it is possible to reduce the hypotensive effect of indapamide. With a significant loss of fluid, acute renal failure may develop (due to a sharp decrease in glomerular filtration). With simultaneous use with calcium preparations, hypercalcemia may develop due to a decrease in the excretion of calcium ions in the urine. With simultaneous use with cardiac glycosides, corticosteroids increases the risk of hypokalemia. With the simultaneous use of drugs that can cause hypokalemia (amphotericin B, gluco- and mineralocorticoids, tetracosactide, laxatives that stimulate intestinal motility), the risk of developing hypokalemia increases. With simultaneous use with tricyclic antidepressants (including imipramine), the hypotensive effect increases and the risk of developing orthostatic hypotension increases (additive effect). With simultaneous use with astemizole, bepridil, erythromycin (in / in), pentamidine, sultopride, terfenadine, vincamine, quinidine, disopyramide, amiodarone, bretylium tosylate, sotalol, there is a risk of developing arrhythmia of the “pirouette” type. With simultaneous use with baclofen, the hypotensive effect is enhanced. With simultaneous use with halofantrine, the likelihood of cardiac arrhythmias (including ventricular arrhythmia of the “pirouette” type) increases. With simultaneous use with lithium carbonate, the risk of developing a toxic effect of lithium against the background of a decrease in its renal clearance increases. With simultaneous use with metformin, lactic acidosis may occur, which is apparently associated with the development of functional renal failure due to the action of diuretics (mainly “loop”). With simultaneous use with cyclosporine, an increase in the content of creatinine in the blood plasma is possible, which is observed even with a normal content of water and sodium ions. Contraindications Acute cerebrovascular accident, severe renal and / or liver dysfunction, severe diabetes mellitus and gout, hypersensitivity to indapamide. Compositionindapamide 2.5 mg Excipients: magnesium stearate, carbomer, lactose monohydrate, hydroxypropyl cellulose, talc, anhydrous colloidal silicon dioxide. Shell composition: Opadry II Pink: (hypromellose, lactose monohydrate, macrogol 3000, glycerol triacetate, black iron oxide (E172), red iron oxide (E172), yellow iron oxide (E172), titanium dioxide (E171)). Side effect On the part of the digestive system: nausea, discomfort or pain in the epigastrium. From the side of the central nervous system: weakness, fatigue, dizziness, nervousness. From the side of the cardiovascular system: orthostatic hypotension. From the side of metabolism: hypokalemia, hyperuricemia, hyperglycemia, hyponatremia, hypochloremia. Allergic reactions: skin manifestations. Buy Indapen retard prolonged-release tablets p/o 1.5mg №15×2 Price for Indapen retard prolonged-release tablets p/o 1.5mg №15×2