Grippostad C capsule №10х1

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Grippostad With caps in a box No. 10×1
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Hard gelatin opaque capsules, size No. 1, cap – yellow, body – white. The main active ingredientCaffeine + paracetamol + chlorphenamine + ascorbic acid Release form capsules Pharmacological properties Combined drug to eliminate the symptoms of colds. Paracetamol has an analgesic (pain reliever) and antipyretic effect. Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration (recovery), in the synthesis of steroid hormones; increases the body’s resistance to infections, reduces vascular permeability, reduces the need for vitamins Bl, B2, A, E, folic acid, pantothenic acid. Improves the tolerance of paracetamol and prolongs its action (slowing down its excretion). Caffeine has an antispasmodic (relaxing) effect, dilates the bronchi, tones the blood vessels of the brain, stimulates the heart, and has a general tonic effect. Chlorphenamine is an antihistamine drug that has an antiallergic effect: it reduces discharge and nasal congestion, lacrimation, and sneezing. The combination of the components of the drug provides better tolerance for the symptoms of malaise and fever in acute respiratory viral infections and other colds. Indications for use Symptomatic treatment of colds accompanied by fever, headache, swelling of the nasal mucosa (rhinitis). Dosage and administration Inside. Adults and children over 15 years old – 2 capsules per dose with a small amount of liquid. If necessary, it should be taken again at the same dose after 4-6 hours 3-4 times a day. The maximum daily dose should not exceed 12 capsules. The use of Grippostad® S during pregnancy and lactation is contraindicated during pregnancy, since epidemiological studies have shown that chlorphenamine increases the risk of CNS anomalies or craniocerebral anomalies and tumors in childhood. The results of one of the studies also indicate an increased risk of retrolental fibroplasia in preterm infants after the use of antihistamines during the last two weeks before delivery. Pregnant women should limit their caffeine intake. Breast-feeding If the use of Grippostad® C is necessary, breast-feeding should be suspended, since it is not known whether chlorphenamine is excreted in breast milk. Caffeine passes into breast milk and can cause agitation and sleep disturbance as it is slowly eliminated from the body of infants. Precautions The use of alcoholic beverages or sedatives (especially barbiturates) increases the sedative effect of chlorphenamine, therefore, these substances should be avoided during treatment. The risk of drowsiness increases with the use of alcoholic beverages, drugs containing alcohol, or sedatives. The risk of predominantly mental dependence appears only at doses exceeding the recommended ones, and with long-term treatment. To avoid the risk of overdose, make sure that other medicines taken by the patient do not contain paracetamol. For adults weighing more than 50 kg, the total dose of paracetamol should not exceed 4 g per day. Caffeine Warning The recommended dose of this product contains approximately the same amount of caffeine as is found in a cup of coffee. While taking the drug, you should limit the use of drugs, drinks and foods containing caffeine, since excessive consumption of caffeine causes nervousness, irritability, insomnia and sometimes tachycardia. Interaction with other drugs Paracetamol The simultaneous use of drugs that slow gastric emptying, such as propaneline, may reduce the rate of absorption of paracetamol and thus slow down its action. Concomitant use of drugs that accelerate gastric emptying, such as metoclopramide, may accelerate the absorption and onset of action of paracetamol. Simultaneous use with zidovudine increases the risk of developing neutropenia. Therefore, the simultaneous use of Grippostad® S and zidovudine is possible only under medical supervision. The use of probenecid inhibits the binding of paracetamol to glucuronic acid and thus leads to a decrease in the clearance of paracetamol by approximately 2 times. When used simultaneously with probenecid, the dose of paracetamol should be reduced. Salicylamides may increase the half-life of paracetamol. Special care should be taken with the simultaneous use of drugs – inducers of microsomal oxidation in the liver, as well as potentially hepatotoxic substances. Repeated doses of paracetamol over several weeks enhance the effect of anticoagulants. Irregular use of paracetamol does not have a significant effect. Cholestyramine reduces the absorption of paracetamol. Chlorphenamine The simultaneous use of chlorphenamine with antidepressants or alcohol potentiates the sedative effect. Caffeine Caffeine may reduce the sedative effect of barbiturates, antihistamines. With simultaneous use with sympathomimetics, thyroxine may increase tachycardia. With simultaneous use with theophylline, theophylline excretion may decrease. The combination of caffeine with broad-spectrum drugs (eg, benzodiazepines) can cause various unpredictable interactions. Oral contraceptives, cimetidine and disulfiram reduce the metabolism of caffeine in the liver; barbiturates and nicotine speed up the metabolism of caffeine. Concomitant use of quinolone inhibitors of DNA gyrase may slow down the excretion of caffeine and its metabolite paraxanthine. Contraindications Hypersensitivity to the components of the drug or other antihistamines, severe liver and / or kidney dysfunction, congenital hyperbilirubinemia, glucose-6-phosphate dehydrogenase deficiency, alcoholism, blood diseases, severe anemia, severe arterial hypertension, unstable angina pectoris. Severe cardiac conduction disorders, acute period of myocardial infarction, severe atherosclerosis, decompensated heart failure, hyperthyroidism, acute urinary retention in prostatic hypertrophy, bladder neck obstruction, pyloroduodenal obstruction, gastric and duodenal ulcer in the acute stage, glaucoma, thrombosis, thrombophlebitis, severe forms of diabetes mellitus, pregnancy and lactation, age up to 15 years, epilepsy, elderly patients. Do not use together with MAO inhibitors and within two weeks after stopping the use of MAO inhibitors. Contraindicated in patients taking tricyclic antidepressants or beta blockers. Urolithiasis – provided that ascorbic acid enters the body at a dose of 1 g per day. galactose, lactase deficiency, glucose-galactose malabsorption (the drug contains lactose). With caution Do not exceed the recommended dose or take the drug for more than 5 days in a row. A doctor should be consulted if symptoms: do not improve within 5 days are accompanied by a fever that persists for more than 3 days include a sore throat that does not go away for more than 3 days is accompanied by fever, headache, rash, nausea or vomiting. The simultaneous use of other medicinal products containing paracetamol should be avoided. When using the drug, it is not recommended to drink alcoholic beverages, since ethyl alcohol while taking paracetamol can cause liver dysfunction. It is essential to consult a physician before using Grippostad® S in patients with the following conditions: Hypertension Cardiovascular disease Diabetes Hyperthyroidism Increased intraocular pressure (i.e. glaucoma) Pheochromocytoma Enlarged prostate Vascular obliterans (eg Raynaud’s phenomenon) Epilepsy Bronchitis Bronchiectasis Bronchial asthma Diseases of the liver and kidneys. Caution should be exercised in patients with impaired renal function and in patients with hepatic insufficiency due to the fact that this drug contains paracetamol and chlorphenamine, which increase the risk of paracetamol-related liver damage. Patients who have been diagnosed with hepatic or renal insufficiency should consult a doctor before taking Grippostad® C. Chlorphenamine may increase the effects of alcohol, so concomitant use should be avoided. Simultaneous use with drugs that cause sedation, such as tranquilizers and sleeping pills, can lead to an increase in sedation, so you should consult a doctor before taking chlorphenamine concomitantly with these drugs. Grippostad® S should not be used with other antihistamines. The elderly are more likely to experience neurological anticholinergic effects and paradoxical arousal (eg, increased energy, restlessness, nervousness). If symptoms persist, see a doctor. Composition 1 capsule contains: active ingredients: ascorbic acid 150.00 mg, caffeine 25.00 mg, paracetamol 200.00 mg, chlorphenamine maleate 2.50 mg; excipients: gelatin, glyceryl tristearate, lactose monohydrate. Capsule shell: capsule body – gelatin, water, titanium dioxide (E 171); capsule cap – gelatin, quinoline yellow (E 104), water, sunset yellow dye (E 110), titanium dioxide (E 171). Overdose Overdose symptoms caused by paracetamol: Liver damage is possible in adults who have taken 10 g or more of paracetamol. Taking 5 g or more of paracetamol can lead to liver damage if the patient has the risk factors listed below. Risk factors If the patient is on long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John’s wort and other drugs that induce liver enzymes. Or b, regularly consumes ethanol in excess of the recommended amounts^ Or c, depleted, eg, cystic fibrosis, HIV infection, starvation. Symptoms Symptoms of an overdose of paracetamol in the first 24 hours include: pallor, nausea, vomiting, loss of appetite and abdominal pain. Liver damage may appear 12 to 48 hours after ingestion. Glucose metabolism disorders and metabolic acidosis may occur. In severe poisoning, liver failure can progress to encephalopathy, bleeding, hypoglycemia, cerebral edema, and death. Acute renal failure with acute necrosis, low back pain, hematuria, and proteinuria may develop even in the absence of severe liver damage. There have been reports of cardiac arrhythmias and pancreatitis. Treatment Immediate measures are essential in the treatment of paracetamol overdose. Despite the absence of significant early symptoms, patients should be referred urgently to the hospital to see a doctor. Symptoms may be limited to nausea or vomiting and may not be consistent with the severity of the overdose or the risk of organ damage. Management should be in accordance with established treatment guidelines. Treatment with activated charcoal should be considered if the overdose was within 1 hour. Plasma concentrations of paracetamol should be measured every 4 hours after ingestion. Treatment with N-acetylcysteine can be used within 24 hours after taking paracetamol, however, the maximum protective effect is achieved up to 8 hours after taking the drug. The effectiveness of the antidote drops sharply after this time. If necessary, N-acetylcysteine should be administered intravenously to the patient, in accordance with the established dosing schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas outside of the hospital. Overdose symptoms caused by potentiation of the parasympathetic action of the antihistamine component Overdose of chlorphenamine may result in effects similar to those listed under adverse reactions. Additional symptoms may include paradoxical arousal, toxic psychosis, convulsions, apnea, dystonic reactions and cardiovascular insufficiency (including arrhythmias), drowsiness that may be arousal (especially in children); depression, oral mucosal ulcers, visual impairment, headache, dizziness, insomnia, coma, convulsions, behavioral changes, arterial hypertension, bradycardia, atropine-like “psychosis”. Overdose symptoms associated with caffeine: CNS stimulation, nervousness, restlessness, insomnia, agitation, muscle cramps, confusion, convulsions. From the side of the cardiovascular system: tachycardia, cardiac arrhythmias. From the gastrointestinal tract: abdominal pain. Other: increased diuresis, redness of the face. Treatment of caffeine overdose is mostly symptomatic and supportive. Due to increased urine output, maintenance of fluid and electrolyte balance should be considered, and CNS symptoms can be managed with intravenous diazepam. Side effects The frequency of possible side effects listed below is defined as follows: Very often (? 1/10) Often (? 1/100 to < 1/10) 10,000 k < 1/1000) Very rare (< 1/10,000) Not known (cannot be estimated from the available data) Laboratory and instrumental data plasma). After the use of ascorbic acid in doses of more than 1 g, an increase in the concentration of ascorbic acid in the urine is possible, which distorts the results of the determination of glucose, uric acid, creatinine and inorganic phosphates in the blood and urine. Also, the use of gram doses of ascorbic acid can give false negative results when analyzing feces for occult blood. Chlorphenamine may underestimate the results of skin allergy tests. Cardiac disorders Not known: arrhythmia (eg, tachycardia). Blood and lymphatic system disorders Very rare: leukopenia, neutropenia, agranulocytosis, thrombocytopenia, thrombocytopenic purpura, pancytopenia, aplastic anemia, metheoglobinemia (when using high doses). Nervous system disorders Very rare: dyskinesia. Not known: lethargy, drowsiness. Eye disorders Very rare: increased intraocular pressure, blurred vision. Respiratory, thoracic and mediastinal disorders Very rare: respiratory hypersensitivity, paracetamol may cause bronchospasm in patients sensitive to aspirin and other NSAIDs. Gastrointestinal disorders Common: dry mouth. Very rare: gastrointestinal complaints (vomiting, abdominal pain, diarrhoea, dyspepsia) Renal and urinary disorders Very rare: urinary disorders. Long-term use in high doses may damage the kidneys. Skin and subcutaneous tissue disorders Uncommon: allergic skin reactions (rash erythematous, urticaria), may be accompanied by fever (drug fever) and mucosal damage. Very rare: Very rare cases of serious skin reactions have been reported. Metabolic and nutritional disorders Very rare: increased appetite. Immune system disorders Very rare: severe hypersensitivity reactions (angioedema, dyspnea, increased sweating, nausea, arterial hypotension, anaphylactic shock) have been described for paracetamol. Not known: Skin hypersensitivity reactions, including in some cases, Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome) were observed. Liver and biliary tract disorders Rare: increased activity of "liver" transaminases. Very rare: liver dysfunction with prolonged use in high doses or as a result of overdose. Mental disorders Very rare: Psychotic reactions (confusion, agitation, irritability, nightmares). Not known: restlessness, insomnia. When the recommended dosage regimen is combined with dietary caffeine intake, higher doses of caffeine may increase the potential for caffeine-related side effects such as insomnia, restlessness, anxiety, irritability, headaches, gastrointestinal disturbances, and palpitations. Storage conditionsAt a temperature not higher than 25°C. Keep out of the reach of children. Buy Grippostad Capsule No. 10x1 Price for Grippostad Capsule No. 10x1