De-Vismuth capsules 120mg №10×6

Name:
De-bismuth
Description:
Capsules hard gelatinous cylindrical shape with white hemispherical ends. The main active ingredient Bismuth tripotassium dicitrate Release form 10 capsules in a blister pack made of PVC film and aluminum foil. Three or six blister packs along with instructions for use in a pack of cardboard. Dosage 120 mg Pharmacological action Antiulcer agent with bactericidal activity against Helicobacter pylori. It also has anti-inflammatory and astringent properties. In the acidic environment of the stomach, insoluble bismuth oxychloride and citrate are precipitated, hepatic compounds with a protein substrate are formed in the form of a protective film on the surface of ulcers and erosions. By increasing the synthesis of prostaglandins E, the formation of mucus and the secretion of bicarbonate, it stimulates the activity of cytoprotective mechanisms, increases the resistance of the mucous membrane of the gastrointestinal tract to the effects of pepsin, hydrochloric acid, enzymes and bile salts. Leads to the accumulation of epidermal growth factor in the area of the defect. Reduces the activity of pepsin and pepsinogen. Indications for use – peptic ulcer of the stomach and duodenum. – gastritis, accompanied by complaints of dyspepsia, in which the eradication of Helicobacter pylori is recommended. Dosage and administration For adults and children over 12 years of age, the drug is prescribed 1 capsule 4 times a day 30 minutes before meals and at night or 2 capsules 2 times a day 30 minutes before meals. Children from 6 to 12 years of age are prescribed at the rate of 8 mg / kg / day. Depending on the weight of the child, 1-3 capsules per day are prescribed (respectively, 1-3 doses per day). In this case, the daily dose should be as close as possible to the calculated dose (8 mg/kg/day). Capsules should be taken 30 minutes before meals with a small amount of water. The duration of the course of treatment is 4-8 weeks. For the next 8 weeks, preparations containing bismuth should not be used. For the eradication of Helicobacter pylori, it is advisable to use De-Bismuth in combination with other antibacterial agents with anti-Helicobacter pylori activity. Use during pregnancy and lactation The use of the drug De-Vismuth during pregnancy and lactation is contraindicated. Precautions The drug should not be used for more than 8 weeks, it is also not recommended to exceed the established daily doses for adults and children during treatment. During treatment with De-Bismuth, other preparations containing bismuth should not be used, as the risk of side effects increases. At the end of the course treatment with the drug in recommended doses, the concentration of the active active substance in the blood plasma does not exceed 3-58 μg / l, and intoxication is observed only at a concentration above 100 mg / l. When using De-Bismuth, it is possible to stain the feces in a dark color due to the formation of bismuth sulfide. Sometimes there is a slight darkening of the tongue. Prolonged use of large doses of bismuth-containing compounds is not recommended, since in some cases this can lead to reversible encephalopathy. The risk of encephalopathy, however, is minimal if De-Bismuth is used at recommended doses. Children The drug is not used in children under 6 years of age. Influence on the ability to drive vehicles and control mechanisms There are no data on the effect of De-Vismuth on the ability to drive vehicles and work with mechanisms. Interaction with other drugs Within half an hour after taking De-Bismuth, it is not recommended to use other medicines orally, as well as the intake of food and liquids, in particular, antacids, milk, fruits and fruit juices. This is due to the fact that, when taken orally, they can affect the effectiveness of De-Bismuth. Contraindications – hypersensitivity to any component of the drug – severe renal dysfunction – pregnancy and lactation – children under 6 years of age Composition 1 capsule contains: active substances: bismuth oxide (in the form of bismuth potassium citrate) – 120.0 mg. excipients: magnesium stearate, anhydrous colloidal silicon dioxide, potato starch. composition of gelatin capsule No. 0: gelatin, purified water, titanium dioxide E-171. OverdoseSymptoms: Acute massive overdose can lead to kidney failure with delayed onset up to 10 days. Treatment: After a single dose of a very high dose, treatment should include gastric lavage, followed by activated charcoal and osmotic laxatives. This reduces the absorption of bismuth, so additional therapeutic measures are not required. The concentration of bismuth in the blood and urine should be determined in case of acute and chronic intoxication, to determine the relationship of symptoms with increased exposure to bismuth. Chelation therapy with dimercaptosuccinic acid (DMSA) or dimercaptopropane sulfonic acid (DMPS) is used if symptoms are known to be caused by acute or chronic bismuth overdose. In severe renal failure after chelation therapy, hemodialysis should be performed. Side effect From the digestive system Very often (≥ 1/10): – blackening of the feces may occur due to the formation of bismuth sulfide, but it can be easily distinguished from melena. Rare (≥ 1/1000, <1/100): - nausea, vomiting, diarrhea or constipation. These phenomena are not dangerous to health and are temporary. On the part of the skin and subcutaneous tissue Rarely (≥ 1/1000, <1/100): mild skin allergic reactions. Immune system disorders Very rare (<1/10000), unknown frequency (cannot be estimated from the available data): anaphylactic reactions. With prolonged use in high doses - encephalopathy associated with the accumulation of bismuth in the central nervous system. Storage conditions In a place protected from moisture and light at a temperature not exceeding 25 ° C. Keep out of the reach of children! Shelf life 2 years Do not use after the expiry date stated on the packaging. Buy De-Bismuth capsules 120mg №10x6