Co-Prenessa tablets 8mg/2.5mg №10×9

NameKo-prenessa 8 mg. Forms of release Tablets. INN Perindopril + indapamide. FTGHypotensive combined means (APF blocker + diuretic). What are Co-Prenessa® Tablets Co-Prenessa® is a combination of two active ingredients, perindopril and indapamide. Perindopril belongs to a class of medicines called angiotensin-converting enzyme inhibitors (ACE inhibitors), which work by dilating blood vessels, making it easier for the heart to pump blood. Indapamide is a diuretic (diuretic). Diuretics increase the amount of urine produced by the kidneys. However, indapamide differs from other diuretics in that it results in only a small increase in urine output. Each of the active ingredients reduces blood pressure, and their combined action allows you to control it. What Co-Prenessa® tablets are used for Co-Prenessa® is an antihypertensive drug used to treat high blood pressure (hypertension). Co-Prenessa® tablets 8 mg/2.5 mg are prescribed to patients who have already taken perindopril 8 mg and indapamide 2.5 mg separately. These patients can take one tablet of Co-Preness®, which contains all the required active ingredients instead of individual tablets. Do not take Co-Prenessa®: if you are allergic to perindopril or another ACE inhibitor, indapamide or another sulfonamide, or any of the other ingredients of this medicine (see “Contents of the pack and other information” section); if you or someone in your family has had symptoms such as wheezing, swelling of the face or tongue, intense itching or extensive rash with a previous use of an ACE inhibitor, or if these symptoms were observed under other circumstances (a condition called angioedema); if you have severe or moderate kidney failure or need dialysis; if you have severe liver disease or suffer from a condition called hepatic encephalopathy (a degenerative disease of the brain); if you have low or high levels of potassium in your blood; if you suspect that you have untreated decompensated heart failure (symptoms may include severe fluid retention and difficulty breathing); if your pregnancy is more than 3 months; it is also better to avoid taking Co-Prenessa® in early pregnancy (see section “Pregnancy and breastfeeding”); if you are breastfeeding; if you have diabetes or impaired kidney function and are being treated with a blood pressure medicine containing aliskiren. Co-Prenessa® should not be used in children. Warnings and precautions Tell your doctor before taking Co-Prenessa®: if you have aortic stenosis (narrowing of the main blood vessel leading away from the heart), hypertrophic cardiomyopathy (heart muscle disease), or renal artery stenosis (narrowing of the artery that supplies the kidney blood); if you have other heart or kidney problems; if you have liver disease; if you suffer from collagenosis (skin disease) such as systemic lupus erythematosus or scleroderma; if you have atherosclerosis (artery disease); if you suffer from hyperparathyroidism; if you have gout; if you have diabetes; if you are on a salt-restricting diet or using salt substitutes that contain potassium; if you are taking lithium or potassium-sparing diuretics (spironolactone, triamterene); their co-administration with Co-Prenessa® should be avoided (see section “Other drugs and Co-Prenessa®”); if you are taking any of the following drugs, the risk of developing angioedema (rapidly developing skin swelling, such as in the throat) is increased: sirolimus, everolimus, and other drugs that belong to the mTOR inhibitor class (used to prevent rejection of organ transplants); if you are taking any of the following medicines used to treat high blood pressure: – an angiotensin II receptor blocker (ARB) (drugs also known as sartans – eg valsartan, telmisartan, irbesartan), in particular if you have problems with the kidneys associated with diabetes – aliskiren. Your doctor may regularly check your kidney function, blood pressure, and electrolytes (such as potassium) in your blood. See also the information under the heading “Do not take Co-Prenessa®”. While taking Co-Prenessa®, you should also tell your doctor: if you are going to have anesthesia and/or surgery, if you have recently had diarrhea, vomiting or dehydration. if you need to undergo hemodialysis or LDL apheresis (hardware removal of cholesterol from your body), if you are planning desensitization to reduce an allergic reaction to bee or wasp stings, – if you need to undergo a medical examination that requires an injection of an iodine-containing contrast agent (a substance that makes organs such as the kidneys or stomach visible on x-rays). You must tell your doctor if you think you are or are planning to become pregnant. Co-Prenessa® is not recommended in early pregnancy and may cause serious harm to your baby after 3 months of pregnancy (see Pregnancy and Breastfeeding section). Your doctor can monitor your treatment with a blood test. Information for athletes This medicine contains an active ingredient that may give a positive reaction in doping controls. Other medicines and Co-Prenessa® Tell your doctor if you are taking, have recently taken or may start taking any other medicines. You should avoid taking Co-Prenessa® with: lithium (used to treat depression) or other drugs that can increase your body’s potassium levels (such as heparin and co-trimoxazole, also known as trimethoprim/sulfamethoxazole). potassium-sparing diuretics (spironolactone, triamterene) and potassium salts. Other medicines may affect the effect of Co-Prenessa®. Be sure to tell your doctor if you are taking any of the following medicines as special care may be needed when taking them: other medicines to treat high blood pressure, procainamide (to treat irregular heartbeats), allopurinol (to treat gout), terfenadine, or astemizole (antihistamines used for seasonal rhinitis or allergies), corticosteroids used to treat a variety of conditions including severe asthma and rheumatoid arthritis, immunosuppressants used to treat autoimmune diseases or after transplant surgery to prevent rejection (eg, cyclosporine), medicines for cancer treatment, erythromycin by injection (antibiotic), halofantrine (used to treat certain types of malaria), pentamidine (used to treat pneumonia), vincamine (used in elderly patients with symptomatic cognitive impairment, including memory loss), bepridil (sp. used to treat angina pectoris), drugs used to treat heart rhythm disorders (eg, quinidine, hydroquinidine, disopyramide, amiodarone, sotalol), digoxin or other cardiac glycosides (to treat heart conditions), baclofen (to treat muscle stiffness associated with diseases such as multiple sclerosis), drugs used to treat diabetes, such as insulin or metformin, calcium, incl. calcium supplements, stimulant laxatives (such as senna), nonsteroidal anti-inflammatory drugs (such as ibuprofen), or high-dose salicylates (such as acetylsalicylic acid amphotericin B by injection (to treat severe fungal infections), drugs used to treat neurological disorders, such as depression, anxiety, and schizophrenia (eg, tricyclic antidepressants, antipsychotics (such as amisulpride, sulpiride, sultopride, tiapride, haloperidol, droperidol)), tetracosactide (for the treatment of Crohn’s disease), gold by injection (for the treatment of rheumatoid arthritis), drugs most commonly used to prevent organ transplant rejection (sirolimus, everolimus, and others in the mTOR inhibitor class) (see Warnings and Precautions section) Your doctor may change your dose and/or take other precautions if you are taking an angio receptor blocker tensin II (ARB) or aliskiren (see See also the information under the headings “Do not take Co-Prenessa®” and “Special instructions and precautions”) Co-Prenessa® with food, drink and alcohol The drug is preferably taken before meals. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to become pregnant, consult your doctor before using this medicine. Pregnancy You must tell your doctor if you think you are pregnant or are planning to become pregnant. Your doctor will likely advise you to stop taking the drug as soon as you know you are pregnant and will advise you to take another drug instead of Co-Preness. Co-Prenessa® is not recommended in early pregnancy and may cause serious harm to your baby if taken beyond 3 months of pregnancy. Breastfeeding Tell your doctor if you are breastfeeding or about to start breastfeeding. Co-Prenessa® is contraindicated in mothers who are breastfeeding and your doctor may recommend other treatment for you if you do not want to stop breastfeeding, especially if your baby is a newborn or was born prematurely. Driving and operating machinery Some patients may experience individual reactions associated with a decrease in blood pressure, such as dizziness or weakness. This may impair their ability to drive or use machines. Important information about excipients If you have been told that you have an intolerance to some sugars, contact your doctor before taking this medicine. Using Co-Prenessa® Always take your medicine exactly as directed by your healthcare professional. Check with your doctor if you are unsure. The usual dose is 1 tablet once a day. Your doctor may change your dosing regimen if you have kidney problems. It is advisable to take the tablet in the morning and before meals. If you have the impression that the effect of the drug is too strong or weak, tell your doctor about it. If you take more Co-Prenessa than you should If you take more than the prescribed dose, contact your doctor or the nearest hospital immediately. The most likely effect of an overdose is low blood pressure. If there is a marked decrease in blood pressure (symptoms include dizziness or weakness), lying down with legs up may improve the condition. If you forget to take Co-Prenessa® Do not take a double dose to make up for a missed one. It is important to take the drug every day, since regular use is the most effective. However, if you forget to take your medicine, take your next dose at the usual time. If you stop taking Co-Prenessa Since treatment for high blood pressure is usually lifelong, you should consult your doctor before stopping Co-Prenessa. If you have any further questions on the use of this drug, ask your doctor. Possible side effects Like all medicines, Co-Prenessa® can cause side effects, although not everybody gets them. If you experience any of the following symptoms, stop taking this medicine immediately and tell your doctor: swelling of your face, lips, mouth, tongue or throat, difficulty breathing, severe dizziness or fainting, unusually fast or irregular heartbeat. When taking the drug, the following adverse reactions may occur: Frequent (may affect less than 1 in 10 people) visual disturbances, ringing in the ears, cough, shortness of breath, gastrointestinal disorders (nausea, epigastric pain, anorexia, vomiting, pain in stomach, taste disturbances, dry mouth, dyspepsia or indigestion, diarrhea, constipation), allergic reactions (such as rash, itching), feeling tired. Uncommon (may affect up to 1 in 100 people) mood swings, sleep disturbances, headache, dizziness, tingling sensation, lightheadedness due to low blood pressure, bronchospasm (chest tightness, wheezing and shortness of breath), angioedema (symptoms such as hoarseness, swelling of the face or tongue), hives, purpura (red spots on the skin), seizures, kidney problems, impotence, sweating. Very rare: (may affect up to 1 in 10,000 people) changes in the amount of blood, impaired consciousness, cardiovascular disorders (irregular heartbeat, angina pectoris, heart attack), eosinophilic pneumonia (a rare type of pneumonia), rhinitis (‘nasal congestion or runny nose ), inflammation of the pancreas (pancreatitis), inflammation of the liver (hepatitis), severe skin manifestations such as erythema multiforme, photosensitivity reactions (changes in the appearance of the skin) after exposure to ultraviolet light or artificial ultraviolet radiation, acute renal failure. Your doctor may order a blood test to monitor your condition. Frequency not known: (frequency cannot be determined from the available data) In case of liver failure (liver problems), hepatic encephalopathy (degenerative disease of the brain) may occur. Reporting Adverse Reactions If you experience any adverse reactions, please consult your physician. This recommendation applies to any possible adverse reactions, including those not listed in this package insert. By reporting adverse reactions, you help to get more information about the safety of the drug. Storage of Co-Prenessa® Store at a temperature not exceeding 30 ° C in a place protected from moisture. Keep out of the reach of children. Shelf life 3 years. Do not use the drug after the expiry date which is stated on the package. The expiry date is the last day of the month. Do not dispose of the drug in the water supply or sewerage. Ask your pharmacist how to dispose of drugs you no longer need. These measures will help protect the environment. The composition of the drug Co-Prenessa®1 tablet contains 8 mg of perindopril erbumine and 2.5 mg of indapamide. Auxiliary ingredients: calcium chloride hexahydrate, lactose monohydrate, crospovidone, microcrystalline cellulose, sodium bicarbonate, hydrated colloidal silicon dioxide, magnesium stearate. Appearance of Co-Prenessa® and contents of the package Tablets are round, slightly biconvex tablets, white or almost white in color, with a notch on one side. The notch is not intended to divide the tablet into equal parts, while it can be used to break the tablet in order to facilitate its swallowing. 10 tablets in a blister (OPA/A1/PVC film and aluminum foil). 3 or 9 blisters with leaflet in a cardboard box. Conditions of release By prescription. Buy Co-Prenessa tablets 8mg/2.5mg No. 10×9