NameCarveland. Release form Tablets. Dosage 25 mg. Qty per pack 30 pcs. ProducerPharmlend sp LLC. INN Carvedilol. FTGalfa- and beta-blocker. Pharmacological action Each tablet of Karveland Pharmland contains the active substance carvedilol – 6.25 mg, 12.5 mg or 25 mg and excipients: lactose monohydrate, sucrose, povidone K-30, crospovidone, anhydrous colloidal silicon dioxide, magnesium stearate, iron oxide yellow E 172 – for a dosage of 12.5 mg, iron oxide (red) E 172 (dosage 25 mg). Belongs to the group of drugs – adrenoblockers. Expands peripheral vessels and reduces their resistance, which leads to a decrease in blood pressure (BP). Moderately reduces conductivity, strength and heart rate (HR). Indications for use Essential hypertension (mild to moderate), as well as chronic angina for the prevention of attacks. Treatment of stable symptomatic mild, moderate and severe chronic heart failure of ischemic or cardiomyopathic origin in addition to standard therapy (diuretics, digoxin, ACE inhibitors). Contraindications Do not take Carveland Pharmland in the following cases: Hypersensitivity to carvedilol or any of the excipients. Chronic heart failure in the stage of decompensation. Chronic obstructive respiratory disease or bronchial asthma. Allergic rhinitis, laryngeal edema. Pulmonary heart. Sick sinus syndrome (including sinoauricular block), atrioventricular (AV) block II and III degree. Severe hypotension (systolic blood pressure < Hg). Severe bradycardia (less than 45-50 beats / min at rest). Cardiogenic shock. Myocardial infarction with complications. Clinical manifestation of liver failure. metabolic acidosis. Simultaneous use of MAO inhibitors (with the exception of MAO-B inhibitors). Established belonging to the number of slow metabolizers of debrisoquine and mephenytoin. Lactation. Age up to 18 years. Fructose or galactose intolerance, Lapp lactase deficiency, malabsorption of glucose-galactose or sucrose-isomaltose. Be sure to consult your doctor if you have the following concomitant diseases or symptoms: chronic bronchitis, heart failure, emphysema, Prinzmetal's angina, diabetes mellitus, hypoglycemia, thyrotoxicosis, peripheral vascular disease, pheochromocytoma, depression, myasthenia gravis, psoriasis, renal failure, before any surgical procedures before the course of desensitization. If you have a diagnosis such as heart failure, you should consult a doctor if you experience / worsen shortness of breath or gain weight. When prescribing Carveland Pharmland, be sure to inform your doctor if you are taking any of the following medicines. Dosage adjustment or additional examinations may be necessary if they are taken together: Digoxin - both drugs slow down the conduction of the heart, the concentration of digoxin in the blood increases, more frequent monitoring of digoxin levels is recommended in blood. Insulin and hypoglycemic agents taken orally - their ability to lower sugar levels is enhanced, regular monitoring of blood glucose levels is recommended. Rifampicin, cimetidine - affect the concentration of carvedilol in the blood. Drugs that reduce the level of catecholamines (reserpine and MAO inhibitors) - a sharp decrease in blood pressure or heart rate is possible, control of blood pressure and heart rate is recommended. Cyclosporine - it is possible to increase the concentration of cyclosporine, it is necessary to adjust its dose. Verapamil, diltiazem or other antiarrhythmic drugs - increased risk of cardiac conduction disorders. Amiodarone, fluconazole - a decrease in heart rate or cardiac conduction is possible, monitoring of heart rate, ECG is recommended. Quinidine, fluoxetine, paroxetine and propafenone - it is possible to increase the level of carvedilol metabolites in the blood. Clonidine - a decrease in blood pressure and heart rate is possible, control of blood pressure and heart rate is recommended. Verapamil, diltiazem - Conduction disturbances are possible, ECG and blood pressure monitoring is recommended. Antihypertensive drugs - it is possible to potentiate their effect or a sharp decrease in blood pressure, blood pressure control is recommended. Anesthetic drugs - possible decrease in heart rate and blood pressure. Non-steroidal anti-inflammatory drugs (NSAIDs) - the combined use of NSAIDs and beta-blockers can lead to an increase in blood pressure and a decrease in blood pressure control. Beta-adrenergic antagonists - since non-cardioselective beta-blockers interfere with the bronchodilator effect of bronchodilators, which are beta-adrenergic stimulants, careful monitoring of patients receiving these drugs is necessary. Use of Carveland Pharmland during pregnancy and lactationCarveland Pharmland should not be used during pregnancy, in case of emergency, it is used as prescribed by a doctor; contraindicated during lactation, if necessary, breastfeeding should be discontinued. Do not give Carveland Pharmland to children Use in children under 18 years of age is contraindicated. Influence on the ability to drive vehicles and control mechanisms Due to possible adverse reactions (dizziness, lethargy), the ability to drive vehicles, mechanisms and perform tasks that require constant attention is reduced, especially at the initial stage of treatment or when increasing the dose, changing therapy. How to use Carveland Pharmland and recommended dosesCarveland Pharmland should be taken with meals, starting with small doses, gradually increasing the dose until the optimal effect is achieved. After the first dose and after each dose change, it is recommended to measure blood pressure in the "standing" position 1 hour after taking the drug, to exclude possible hypotension. Therapy is canceled gradually, reducing the dose within 1-2 weeks. Essential hypertension The recommended starting dose is 12.5 mg once daily for the first 2 days. After 7-14 days of treatment (if necessary - after 2 days) 25 mg once a day. If necessary, the dose can be increased at intervals of no more than 2 weeks, reaching the highest recommended dose of 50 mg 1 time per day (or divided into 2 doses). Chronic angina The recommended starting dose is 12.5 mg twice a day. If necessary, the dose can be increased at intervals of at least 2 weeks, leading up to the highest daily dose of 100 mg, divided into 2 doses. For elderly patients, the highest daily dose is 50 mg divided into 2 doses. Chronic heart failure The dose is selected individually. In patients receiving cardiac glycosides, diuretics and ACE inhibitors, doses should be adjusted prior to treatment with Carveland Pharmland. the drug is also prescribed for intolerance to ACE inhibitors. The initial dose is 3.125 mg (1/2 tablet, 6.25 mg each) 2 times a day. With good tolerance, the dose is gradually (with an interval of 2 weeks) increased to the optimal value. The next dose is 6.25 mg (1/2 tablet of 12.5 mg or 1 tablet of 6.25 mg) 2 times a day, then 12.5 mg 2 times a day and finally 25 mg 2 times a day. The highest tolerated dose is recommended to the patient. The maximum recommended dose is 25 mg (1 tablet of 25 mg) 2 times a day. If body weight exceeds, then the dose may be increased to 50 mg (2 tablets of 25 mg) 2 times a day. If treatment with Carveland Pharmland is interrupted for more than 2 weeks, therapy is resumed at a dose of 3.125 mg, the dose is increased at two-week intervals. Dosage in special groups of patients Impaired renal function. Dose adjustment is not required. Impaired liver function. Carveland Pharmland is contraindicated in patients with evidence of hepatic impairment. Elderly patients. The initial dose is 12.5 mg once a day. In case of insufficient effectiveness, the dose can be gradually increased at intervals of at least 2 weeks up to a maximum dose of 50 mg per day. Treatment is usually long-term, canceled gradually (within 1-2 weeks), the dose is reduced by half every 3 days. It is necessary to inform the doctor about any change in health while taking Karveland Pharmland (changes in heart rate, blood pressure, body weight)! It may be necessary to adjust the dose of the medications taken. If you take more Carveland Pharmland than your doctor recommended If you take more tablets per day than your doctor recommended, or if your child has swallowed the tablets, call your doctor or call an ambulance! An overdose is likely to cause a pronounced decrease in blood pressure, heart rate, heart failure; possible cardiac arrest, respiratory failure, vomiting, confusion and convulsions. Stop taking the medicine. As a first aid: lay the patient on his back so that the head is lowered and the legs are raised; gastric lavage or induce vomiting. If you forget to take your next dose of Carveland Pharmland Take your tablet as soon as you remember, making sure there is time before your next dose. If there is little time before the next dose, take as directed by your doctor. Do not take a double dose if you miss the next dose. Possible adverse reactions Classification of the incidence of side effects according to WHO: very often (≥1/10), often (≥1/100 to 1/<10), infrequently (≥1/1000 to <1/100), rarely (≥1/100) 10,000 to <1/1000), very rare (<1/10,000), frequency not known (cannot be estimated from available data). Very common: dizziness, headache; progression of heart failure; arterial hypotension; asthenia, fatigue. Often: bronchitis, pneumonia, upper respiratory tract infections, urinary tract infections; anemia; weight gain, increased cholesterol, abnormal blood glucose levels (hyperglycemia, hypoglycemia) in patients with a history of diabetes, hyperuricemia, hyponatremia, increased alkaline phosphatase, glycosuria, hypervolemia, diabetes mellitus, increased GGTP (GGT), weight loss body, hyperkalemia, elevated creatinine; nervousness, depression, depressed mood, decreased concentration, pathological thinking, nightmares, emotional instability; blurred vision, dry eyes, irritation of the mucous membrane of the eyes, blurred vision; tinnitus, hearing loss; bradycardia, edema, hypervolemia, fluid retention; orthostatic hypotension, impaired peripheral circulation (cold extremities, peripheral vascular disease, intermittent claudication, Raynaud's syndrome); dyspnea, pulmonary edema, asthma (in predisposed patients); nausea, diarrhea, vomiting, dyspepsia, abdominal pain, tarry stools, periodontitis; pain in the limbs, cramps; acute renal failure and impaired renal function in patients with widespread peripheral vascular disease and / or impaired renal function, the presence of blood or protein in the urine, frequent urination; pain sensations. Uncommon: sleep disorder, drowsiness; presyncope, syncope, vertigo, hypesthesia, paresthesia, hypokinesia, dry mouth, increased sweating; atrioventricular blockade, angina pectoris; skin reactions (allergic dermatitis, urticaria, itching, exacerbation of psoriatic rashes, a reaction similar to lichen planus), alopecia; erectile dysfunction. Rarely: a decrease in the number of platelets, prothrombin, purpura; nasal congestion. Very rarely: a decrease in the number of leukocytes; allergic reactions; changes in liver blood tests; involuntary urination in women. Precautions for taking Carveland PharmlandCarveland Pharmland should not be used in children; with unstable or secondary hypertension; unstable angina; complete interventricular blockade; the final stage of peripheral arterial circulatory disorders; fresh myocardial infarction; tendency to lower blood pressure; concomitant treatment with alpha1 receptor antagonists. Termination of therapy. The drug should be discontinued within 1-2 weeks with limited physical activity. If the condition worsens, consult a doctor. Chronic heart failure. During the period of dose selection, there may be an increase in symptoms of chronic heart failure or fluid retention. It is necessary to consult a doctor. Bronchospasm diseases. Patients with chronic bronchitis, emphysema should not take the drug. Carveland Pharmland is used as prescribed by a doctor in cases where the effect of other antihypertensive drugs has not been obtained. If shortness of breath or the first symptoms of bronchospasm appear, you should consult a doctor. Diabetes. It is used with caution in patients with diabetes mellitus, may mask or reduce the symptoms of hypoglycemia (especially tachycardia). Blood glucose monitoring is recommended, especially when changing the dose or stopping carvedilol. Peripheral vascular disease. Use with caution in patients with peripheral vascular disease (including Raynaud's syndrome), may increase symptoms of arterial insufficiency. thyrotoxicosis. Carveland Pharmland may reduce the symptoms of thyrotoxicosis. General anesthesia and major surgery. If it is necessary to perform a surgical intervention using general anesthesia, it is necessary to warn the anesthetist about taking Carveland Pharmland. Bradycardia. Carveland Farmland can cause a decrease in heart rate. It is necessary to consult a doctor. Hypotension. The drug can cause a decrease in blood pressure of varying severity. Prescribing low doses at the beginning of treatment, taking the drug during meals and gradually increasing doses reduce the likelihood of this phenomenon. At the initial stage of treatment, driving a vehicle or performing tasks that require increased attention should be avoided. Increased sensitivity. With caution, the drug is used by patients with severe hypersensitivity reactions in the past or undergoing desensitization. Severe adverse skin reactions. Carveland Pharmland should not be taken by patients who have had severe adverse skin reactions in the past. Psoriasis. Patients with psoriasis are used only on the advice of a doctor. Simultaneous reception of blockers of "slow" calcium channels. Patients concomitantly taking drugs such as verapamil or diltiazem, as well as other antiarrhythmic drugs, are recommended to monitor the ECG and blood pressure. Pheochromocytoma. Use with caution in patients with pheochromocytoma or suspected pheochromocytoma. Prinzmetal's angina. It is used with caution due to the possible occurrence of pain. Intraoperative syndrome of atonic iris. If cataract surgery is necessary, inform the doctor about taking the drug to select the operation technique. Contact lenses. Against the background of the reception, a decrease in the amount of lacrimal fluid is possible. Liver damage. Undesirable reactions from a liver are possible, as a rule, reversible. When the first symptoms of liver dysfunction appear (itching, dark urine, loss of appetite, jaundice, pressing pains in the right hypochondrium), it is necessary to stop taking the drug and consult a doctor. During the period of treatment, the use of alcohol is excluded. The medicinal product contains lactose and sucrose and should not be used in cases of fructose/galactose intolerance, Lapp lactase deficiency, glucose-galactose/sucrose-isomaltose malabsorption. Storage conditionsKeep in a place protected from light at a temperature not exceeding 25°C. Keep out of the reach of children. Shelf life 2 years. Do not use after the expiration date. Terms of dispensing from pharmacies By prescription. Packing: 10 tablets in a blister pack made of aluminum foil and PVC film and 30 tablets in a polymer jar with a pull-on lid with first opening control, sealant - medical cotton wool. Each can, 3 or 6 (tablets 25 mg) blister packs with a leaflet in the secondary packaging. Buy Karveland tablets 25mg No. 10x3
INN | CARVEDILOL |
---|---|
The code | 129 644 |
Barcode | 4 810 368 013 279 |
Dosage | 25mg |
Active substance | Carvedilol |
Manufacturer | Pharmland SP LLC, Belarus |
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