Glucose solution for infusions 50mg/ml in containers 100ml №1

Name Glucose solution for inf. 50 mg/ml in a polymeric cont. the introduction, the doctor is obliged to conduct a visual inspection of the polymer container with the drug. The solution must be clear, free of suspended particles or sediment. The drug is considered suitable for use if the label is present and the packaging is sealed. Hypertonic solutions are administered intravenously. The concentration and dose of the administered solution depend on the age, body weight and clinical condition of the patient. The use of the drug should be carried out under regular medical supervision. Clinical and biological parameters, in particular the concentration of glucose in the blood, as well as the water-salt balance, should be carefully monitored. The maximum infusion rate should not exceed the patient’s glucose utilization threshold, as this may lead to hyperglycemia. Depending on the clinical condition of the patient, the rate of administration may be reduced to reduce the risk of osmotic diuresis. A 200 mg/ml solution is injected intravenously at a rate of up to 30-40 drops/min (1.5-2 ml/min), which corresponds to about 120 ml/hour. The maximum daily dose for adults is 500 ml. A 400 mg/ml solution is injected intravenously at a rate of up to a maximum of 16 drops/min (0.8 ml/min), which corresponds to approximately 48 ml/hour. The maximum daily dose for adults is 250 ml. When diluted to 100 mg / ml of solution, the maximum infusion rate is up to 60 drops / min, the volume is 500 ml / day. When diluted to 50 mg / ml of solution, the maximum infusion rate is up to 150 drops / min, the volume of administration is up to 2 l / day. For a more complete assimilation of glucose, administered in large doses, simultaneously with it, insulin is prescribed at the rate of 1 IU of insulin per 4-5 g of glucose. Patients with diabetes, glucose is administered with caution under the control of blood sugar and urine. Children and adolescents The exact dose and rate of infusion of glucose solutions should be determined by the attending physician experienced in infusion therapy in children. Elderly patients Doses generally recommended for adults are used, but caution should be exercised in determining fluid volumes and dextrose dose in patients with cardiac or renal insufficiency. Patients with reduced glucose metabolism (for example, in the early postoperative or post-traumatic period, with hypoxia, or organ failure): The concentration of glucose in the blood should be carefully monitored. To avoid hyperglycemia, the level of possible glucose oxidation should not be exceeded. Use during pregnancy and lactation Glucose solutions should be administered with caution to women during pregnancy and lactation. The use of the drug during pregnancy and during breastfeeding is possible only on prescription, if the intended benefit to the mother outweighs the potential risk to the fetus or child. The use of the drug in pregnant women with normoglycemia can cause fetal hyperglycemia, metabolic acidosis. The latter is important to consider, especially when fetal distress or hypoxia is already due to other perinatal factors. Precautions When using the drug, it is necessary to monitor the water and electrolyte balance and the level of glucose in the blood serum. With prolonged intravenous use of the drug, control of blood sugar levels is necessary. It is not recommended to prescribe a Glucose solution during the acute period of severe traumatic brain injury, with acute cerebrovascular accident, since the drug can increase damage to brain structures and worsen the course of the disease (with the exception of cases of correction of hypoglycemia). In case of hypokalemia, the administration of glucose solution must be combined simultaneously with the correction of potassium deficiency (due to the danger of increasing hypokalemia). For better absorption of glucose in normoglycemic conditions, it is desirable to combine the administration of the drug with the appointment (subcutaneously) of fast-acting insulin at the rate of 1 unit per 4–5 g of glucose (dry matter). Do not use the solution subcutaneously or intramuscularly. Glucose solution should not be administered quickly or for a long time. If chills occur during administration, administration should be discontinued immediately. To prevent thrombophlebitis, it should be administered slowly through large veins. In renal failure, decompensated heart failure, hyponatremia, special care is required when prescribing glucose, monitoring of central hemodynamic parameters. The contents of the container can only be used for one patient, after the leakage of the container, the unused part of the contents of the container should be discarded. Interaction with other drugs Glucose is incompatible in solutions with aminophylline, soluble barbiturates, erythromycin, hydrocortisone, warfarin, kanamycin, soluble sulfonamides, cyanocobalamin. Glucose solution should not be administered in the same infusion set as blood due to the risk of non-specific agglutination. Since glucose solution for intravenous infusion is acidic (pH<7), incompatibility may occur when administered simultaneously with other medicinal products. When combined with other drugs, it is necessary to clinically monitor their possible incompatibility. Glucose solutions 200 and 400 mg/ml should not be administered in the same syringe with hexamethylenetetramine, since glucose is a strong oxidizing agent. It is not recommended to mix in one syringe with alkaline solutions: with general anesthetics and sleeping pills, as their activity decreases, with alkaloid solutions; inactivates streptomycin, reduces the effectiveness of nystatin. Under the influence of thiazide diuretics and furosemide, glucose tolerance decreases. Insulin promotes the entry of glucose into peripheral tissues, stimulates the formation of glycogen, the synthesis of proteins and fatty acids. Glucose solution reduces the toxic effect of pyrazinamide on the liver. The introduction of a large volume of glucose solution contributes to the development of hypokalemia, which increases the toxicity of simultaneously used digitalis drugs. Contraindications Glucose solution 50 mg / ml is contraindicated in patients with: Intracranial and intraspinal hemorrhages, except for conditions associated with hypoglycemia; Severe dehydration, including alcoholic delirium; Hypersensitivity to dextrose and other components of the drug; Anuria; Diabetes mellitus and other conditions accompanied by hyperglycemia. Hyperlactacidemia, hyperosmolar coma; Hyperhydration, cerebral and pulmonary edema, acute left ventricular failure; Circulatory disorders threatening swelling of the brain and lungs; Carefully. Decompensated chronic heart failure, chronic renal failure (oligo-, anuria), hyponatremia, diabetes mellitus. The drug should not be administered simultaneously with blood products. Composition 50 mg/ml 100 mg/ml 100 ml 250 ml 500 ml 1000 ml 100 ml 250 ml 500 ml Active ingredients: Glucose anhydrous 5 g 12.5 g 25 g 50 g 10 g 25 g 50 g Overdose Hyperglycemia and hyperhydration may develop. At the same time, patients experience dry skin and mucous membranes, a decrease in eyeball tension, frequent shallow breathing without the smell of acetone, tachycardia, arrhythmia, loss of consciousness, and an increase in body temperature are possible. In case of an overdose of the drug, symptomatic treatment and the administration of regular insulin drugs at a dose of 0.1 U / kg intramuscularly or intravenously are prescribed. Side effect Hypervolemia, acute left ventricular failure; when the rate of administration is exceeded, osmotic diuresis with loss of water, electrolytes and the development of hyperosmolar coma. At the injection site? development of infection, thrombophlebitis. Electrolyte imbalance and general body reactions that occur during massive infusions: hyponatremia, hypokalemia, hypophosphatemia; hypomagnesemia, hypervolemia; hyperglycemia, allergic reactions (hyperthermia, skin rash, angioedema, shock); vein thrombosis. From the gastrointestinal tract: very rarely - nausea of central origin. In case of adverse reactions, the administration of the solution should be stopped, the patient's condition should be assessed and assistance should be provided. Storage conditionsStore at temperatures between 5°C and 30°C. Do not freeze. Keep out of the reach of children. Buy Glucose solution for infusion 50mg/ml in containers 100ml №1