Glucose solution for intravenous injection 400mg/ml in ampoules 5ml №10

Glucose Solution for Intravenous Injection 400mg/ml in Ampoules 5ml №10

Description:

Glucose solution for intravenous injection is a sterile, non-pyrogenic solution of glucose in water for injection. It is indicated for the treatment of hypoglycemia and as a source of carbohydrates in parenteral nutrition.

Key Features:

• High concentration: 400mg/ml glucose solution provides a concentrated source of energy.
• Convenient packaging: Ampoules of 5ml, packaged in boxes of 10, offer easy administration.
• Trusted manufacturer: Produced by Borisov ZMP, a reputable pharmaceutical company.
• Versatile application: Can be used for various indications, including hypoglycemia and parenteral nutrition.

Composition:

Each ampoule (5 ml) contains:

• Active substance: Glucose (anhydrous) – 2000 mg
• Excipients: Concentrated hydrochloric acid, sodium chloride, water for injection.

Pharmacological Properties:

Glucose is a simple sugar that is essential for energy production in the body. When administered intravenously, it provides a rapid and readily available source of energy.

Indications for Use:

• Hypoglycemia: For the treatment of low blood sugar levels.
• Parenteral nutrition: As a source of carbohydrates in patients who cannot receive adequate nutrition orally or enterally.

Contraindications:

• Hyperglycemia: High blood sugar levels.
• Diabetes mellitus: A condition where the body cannot regulate blood sugar levels properly.
• Postoperative disorders of glucose utilization: Impaired glucose metabolism after surgery.
• Hyperlactacidemia: Elevated lactic acid levels in the blood.
• Hyperosmolar coma: A condition characterized by high blood sugar levels and dehydration.
• Hyperhydration: Excessive fluid in the body.
• Cerebral and pulmonary edema: Fluid buildup in the brain or lungs.
• Acute left ventricular failure: A serious heart condition.
• Hypersensitivity to the drug: Allergic reactions to any component of the solution.
• Circulatory disorders: Conditions affecting blood flow.
• Hemorrhages in the brain and spinal cord (except for conditions accompanied by hypoglycemia): Bleeding in these areas.
• Childhood: Not recommended for use in children.

Dosage and Administration:

• Hypertonic solution 400 mg/ml: Administered intravenously at a rate of up to 30 drops/min (1.5 ml/min), corresponding to approximately 48 ml/hour.
• Maximum daily dose for adults: 250 ml.
• Maximum daily dose for children: 15 ml/kg/day (6 g/kg/day).
• Maximum infusion rate: 0.62 ml/kg/h (0.25 g/kg/h).

Precautions:

• Do not administer quickly or for extended periods.
• Monitor fluid and electrolyte balance and serum glucose levels regularly.
• Use with caution in patients with acute cerebrovascular accident.
• Do not use subcutaneously or intramuscularly.
• Discard unused portion of the ampoule after opening.
• Consult a healthcare professional for specific dosage and administration instructions.

Side Effects:

• Common side effects: Hypokalemia, hypomagnesemia, hypophosphatemia, hyperglycemia, hemodilution, dehydration, hypervolemia, venous thrombosis, phlebitis, sweating, polyuria, chills, fever, injection site reactions.
• Rare side effects: Anaphylactic reactions, hypersensitivity.

Drug Interactions:

• Insulin: Improves glucose uptake by tissues.
• Potassium salts: Enhance glucose uptake.
• Sodium chloride solutions: Additive effect on osmolarity.
• Alkaloids: Decomposition may occur.
• General anesthetics: Decreased activity.
• Hypnotics: Reduced activity.
• Analgesics and adrenomimetic agents: Activity weakened.
• Streptomycin, nystatin: Activity reduced.
• Hexamethylenetetramine: Incompatibility due to oxidizing properties of glucose.
• Thiazide diuretics and furosemide: Decreased glucose tolerance.
• Digitalis drugs: Increased toxicity due to hypokalemia.
• Barbiturates, erythromycin, aminophylline, hydrocortisone, warfarin, kanamycin, soluble sulfonamides, cyanocobalamin: Incompatibility in solutions.
• Blood: Risk of nonspecific agglutination.

Overdose:

• Symptoms: Hyperglycemia, thirst, polyuria, polydipsia, acute left ventricular failure.
• Treatment: Withdrawal of the drug, administration of insulin under glycemic control, symptomatic therapy.

Storage:

• Store at temperatures between 5°C and 30°C.
• Keep out of reach of children.
• Do not use after the expiry date.

Dispensing:

Available by prescription.

Please note: This information is provided for general knowledge and informational purposes only, and does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis and treatment of any medical condition.