Ginezol 7 vaginal suppositories 100mg №7×1

DescriptionLarge, white or whitish opaque ovoid suppository with a rounded end. The main active ingredient Miconazole Release form Suppositories Dosage 100 mg Pharmacological properties Miconazole is an imidazole derivative. Active against most Candida spp; Aspergillus spp. Dimorphons fungi; Cryptococcus neoformans; Pityrosporum sp. Topulopsis glabrata. Miconazole inhibits the biosynthesis of ergosterol and changes the lipid composition of the membrane, causing the death of the fungal cell. It is also active against some Gram-positive microorganisms. Pharmacokinetics After the introduction of the suppository into the vagina, the active substance is released. Systemic absorption after intravaginal use is limited. 8 hours after application of the drug, 90% of miconazole is still present in the vagina. Unchanged miconazole is not detected in either plasma or urine. Indications for use Vaginal and vulvovaginal candidiasis; superinfection caused by gram-positive microorganisms. Dosage and administration 1 suppository is injected deep into the vagina 1 time per day at bedtime for 7 days. The course of treatment should not be interrupted. Use during pregnancy and lactation During the II and III trimester of pregnancy, the drug can be used only in cases where, in the opinion of the doctor, the expected benefit to the woman outweighs the potential risk to the fetus. It is not known whether miconazole passes into breast milk, however, the drug should be used with caution during breastfeeding. Precautions Solid fat can destroy the latex of condoms and diaphragms. Condoms and diaphragms should not be relied upon to prevent pregnancy and protect against sexually transmitted diseases. Do not use tampons while using suppositories. If the sexual partner has an infection, he should also be prescribed appropriate treatment. Interaction with other drugs Simultaneous use of vaginal suppositories containing miconazole and indirect anticoagulants of the coumarin series (for example, warfarin) can lead to an increase in the concentration of indirect anticoagulants in the blood plasma. The onset of symptoms, such as bleeding, spontaneous bruising, and monitoring of the international normalized ratio (INR) should be monitored. ContraindicationsIncreased individual sensitivity to imidazoles or other components of the drug. Children’s age up to 12 years. Pregnancy period (I trimester). With caution – diabetes mellitus, impaired microcirculation. Active ingredient: miconazole nitrate 100 mg. Excipient: solid fat 2400 mg. Overdose There are no data on overdose of miconazole nitrate in humans. Side effects When using suppositories, local reactions are possible, especially at the beginning of treatment: irritation, itching, burning sensation in the vulva and vagina. Storage conditions At a temperature not exceeding 30 ° C, out of the reach of children. Buy Ginezol 7 vaginal suppositories 100mg No. 7×1 Price for Ginezol 7 vaginal suppositories 100mg No. 7×1