Ezocar capsules 20mg №5×3

The following adverse reactions were identified during clinical trials of esomeprazole and during post-registration safety monitoring. No dose-dependence was determined for any of the adverse reactions. The frequency of adverse reactions is indicated in accordance with the following classification: very common (>1/10), frequent (>1/100 to <1/10), infrequent (>1/1000 to <1/100), rare (>1/100). 10000 to <1/1000), very rare (<1/10000); the frequency is not known (cannot be determined from the available data). From the hemopoietic system: rare – leukopenia, thrombocytopenia; very rare – agranulocytosis, pancytopenia. From the immune system: rare – hypersensitivity reactions such as fever, angioedema and anaphylactic reactions / shock. From the side of metabolism: infrequent – peripheral edema; rare – hyponatremia; very rare – hypomagnesemia, severe hypomagnesemia may be associated with hypocalcemia. On the part of the psyche: infrequent – insomnia; rare – agitation, confusion, depression; very rare – aggressiveness, hallucinations. From the nervous system: frequent – headache; infrequent – dizziness, paresthesia, drowsiness; rare – taste disorders. On the part of the organ of vision: rare – blurred vision. On the part of the organ of hearing and labyrinth: infrequent – dizziness. From the respiratory system: rare – bronchospasm. From the digestive system: frequent – abdominal pain, constipation, diarrhea, flatulence, nausea / vomiting; infrequent – dryness of the oral mucosa, increased activity of liver enzymes; rare – stomatitis, gastrointestinal candidiasis, hepatitis with or without jaundice; very rare – liver failure, encephalopathy in patients with previous liver disease; the frequency is not known – microscopic colitis. From the skin and subcutaneous tissue: infrequent – dermatitis, itching, rash, urticaria; rare – alopecia, photosensitivity; very rare – erythema multiforme, Steven-Johnson syndrome, toxic epidermal necrolysis. From the musculoskeletal system: rare – arthralgia, myalgia; very rare – muscle weakness, bone fractures. From the urinary system: very rare – interstitial nephritis. From the reproductive system and mammary glands: very rare – gynecomastia. On the part of the body as a whole: rare – weakness, increased sweating.