Drotaverine Solution for Intravenous and Intramuscular Injection 20mg/ml in Ampoules 2ml №10: Effective Relief for Smooth Muscle Spasms

Experience fast and effective relief from smooth muscle spasms with Drotaverine Solution, a potent antispasmodic medication available in convenient 2ml ampoules.

What is Drotaverine Solution?

Drotaverine Solution is a prescription medication containing drotaverine hydrochloride, a potent antispasmodic agent that works by relaxing smooth muscles throughout the body. It is primarily used to treat painful spasms associated with conditions affecting the biliary tract and urinary tract.

Key Features:

• Fast and Complete Absorption: Drotaverine is rapidly absorbed following intravenous or intramuscular administration, ensuring quick relief from spasms.
• Potent Antispasmodic Action: Drotaverine effectively relaxes smooth muscles by inhibiting PDE IV, leading to increased cAMP levels and ultimately muscle relaxation.
• Convenient Ampoules: Each pack contains 10 ampoules, each containing 2ml of solution, making it easy to administer.
• Dosage Flexibility: Drotaverine Solution can be administered intravenously or intramuscularly, allowing for flexible treatment options based on individual needs.

Uses:

Drotaverine Solution is indicated for the treatment of spasms of smooth muscles associated with the following conditions:

Biliary Tract:

• Cholecystolithiasis (gallstones in the gallbladder)
• Cholangiolithiasis (gallstones in the bile ducts)
• Cholecystitis (inflammation of the gallbladder)
• Pericholecystitis (inflammation around the gallbladder)
• Cholangitis (inflammation of the bile ducts)
• Papillitis (inflammation of the papilla of Vater)

Urinary Tract:

• Nephrolithiasis (kidney stones)
• Urethrolithiasis (stones in the urethra)
• Pyelitis (inflammation of the renal pelvis)
• Cystitis (inflammation of the bladder)
• Bladder tenesmus (painful urination)

Important Information:

Contraindications:

Drotaverine Solution is contraindicated in individuals with hypersensitivity to drotaverine or any of the excipients, severe hepatic, renal or heart failure, and in children.

Precautions:

Caution is advised for patients with arterial hypotension, severe atherosclerosis of the coronary arteries, and during pregnancy.

Pregnancy and Breastfeeding:

While Drotaverine is not known to cause teratogenic or embryotoxic effects, caution is advised during pregnancy. It is not recommended for use during childbirth or breastfeeding due to lack of clinical data.

Driving and Operating Machinery:

Intravenous administration of Drotaverine can cause dizziness, so patients are advised to refrain from driving or engaging in hazardous activities until they are fully recovered.

Dosage and Administration:

The recommended dosage of Drotaverine Solution for adults is 40-240mg of drotaverine hydrochloride per day, divided into 1-3 injections.

Intramuscular Administration:

The average dose is 40-80mg (2-4ml) intramuscularly.

Intravenous Administration:

For acute colic (biliary and urolithiasis), the average dose is 40-80mg (2-4ml) administered slowly intravenously. The patient must lie down during intravenous administration due to the risk of collapse.

Potential Side Effects:

Like all medications, Drotaverine Solution can cause side effects. The most common side effects include:

• Gastrointestinal Tract: Rarely – nausea, constipation.
• Central Nervous System: Rarely – headache, dizziness, insomnia.
• Cardiovascular System: Rarely – palpitations, hypotension.
• Immune System: Rarely – allergic reactions, including angioedema, urticaria, rash, itching, fever, chills, weakness, especially in patients with hypersensitivity to metabisulphite.
• General: Reactions at the injection site.
• Anaphylactic Shock: There have been reports of anaphylactic shock with fatal and non-fatal consequences when using the injectable form.

Interactions with Other Drugs:

Drotaverine Solution can interact with other medications. It is crucial to inform your doctor about all the medications you are currently taking, including over-the-counter drugs and herbal supplements.

Important Interactions:

• Levodopa: Drotaverine may weaken the antiparkinsonian effect of levodopa.
• Papaverine, Bendazole, Antispasmodics: Drotaverine enhances the effects of papaverine, bendazole, and other antispasmodics.
• Tricyclic Antidepressants, Quinidine, Procainamide: The hypotensive effect of drotaverine can be enhanced with the simultaneous use of tricyclic antidepressants, quinidine, and procainamide.
• Morphine: Drotaverine reduces the spasmogenic activity of morphine.
• Phenobarbital: Phenobarbital increases the antispasmodic effect of drotaverine.

Overdose:

In case of an overdose, seek immediate medical attention. Overdose symptoms may include cardiac arrhythmias, conduction disturbances, complete bundle branch block, and cardiac arrest.

Storage:

Store Drotaverine Solution in a cool, dry place protected from light at a temperature between 15°C and 25°C. Keep it out of reach of children.

Disclaimer:

This information is intended for educational purposes only and should not be considered medical advice. Always consult your doctor or healthcare professional before starting any new medication or treatment.