Co-amlessa pills 8mg/10mg/2.5mg №10×3

Co-Amlessa Tablets: A Comprehensive Guide to Dosage, Side Effects, and Interactions

Co-Amlessa tablets are a triple-combination antihypertensive medication used to treat high blood pressure. This medication contains perindopril, indapamide, and amlodipine, three potent drugs that work together to effectively lower blood pressure. This comprehensive guide will provide you with detailed information on Co-Amlessa, including its dosage, side effects, interactions, and precautions.

Important Note: This information is for general knowledge purposes only and should not be considered medical advice. Always consult with your doctor or pharmacist for personalized advice and guidance regarding this medication.

What is Co-Amlessa?

Co-Amlessa combines three active ingredients:

• Perindopril: An angiotensin-converting enzyme (ACE) inhibitor that blocks the production of substances that narrow blood vessels.
• Indapamide: A chlorosulfamoyl diuretic that helps your body eliminate excess water and salt, thereby reducing blood pressure.
• Amlodipine: A calcium channel blocker that relaxes blood vessels and improves blood flow.

Dosage and Administration

The recommended dosage of Co-Amlessa is one tablet once daily, preferably in the morning before meals. The specific dosage and formulation will be determined by your doctor based on your individual needs and medical history.

Available Dosages:

• Co-Amlessa 8mg/10mg/2.5mg tablets
• Co-Amlessa 4mg/10mg/1.25mg tablets
• Co-Amlessa 4mg/5mg/1.25mg tablets
• Co-Amlessa 2mg/5mg/0.625mg tablets

Important Notes on Dosage:

• Renal Impairment: This drug is contraindicated in patients with severe renal insufficiency (creatinine clearance < 30 ml/min). Dosages of 8 mg/5 mg/2.5 mg and 8 mg/10 mg/2.5 mg are contraindicated in patients with moderate renal impairment (creatinine clearance 30-60 ml/min).
• Hepatic Impairment: This medication is contraindicated in patients with severe liver dysfunction. Caution is recommended when prescribing Co-Amlessa to patients with mild or moderate hepatic impairment.
• Elderly Patients: Excretion of perindoprilat (an active metabolite of perindopril) is slowed down in elderly patients. Dosage adjustments may be necessary based on renal function.
• Children: The safety and efficacy of Co-Amlessa in children and adolescents have not been established.

Side Effects

Like all medications, Co-Amlessa can cause side effects, although not everyone experiences them. Some common side effects include:

• Hypotension (low blood pressure)
• Dizziness
• Headache
• Fatigue
• Nausea
• Cough
• Muscle cramps
• Edema (swelling)

Serious Side Effects

In rare cases, more serious side effects can occur. It is crucial to contact your doctor immediately if you experience any of the following:

• Angioedema (swelling of the face, lips, tongue, or throat)
• Severe skin reactions (rash, itching, blistering)
• Abnormal heart rhythm
• Kidney problems
• Liver problems
• Hyperkalemia (high potassium levels in the blood)

Drug Interactions

Co-Amlessa can interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. It is important to inform your doctor about all the medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins.

Some significant drug interactions include:

• Potassium-sparing diuretics (amiloride, spironolactone, triamterene)
• Potassium supplements
• Lithium
• NSAIDs (non-steroidal anti-inflammatory drugs)
• Antidiabetic drugs (insulin, oral hypoglycemics)
• Grapefruit juice

Precautions

It is crucial to inform your doctor about any pre-existing medical conditions before starting Co-Amlessa, such as:

• Renal impairment
• Hepatic impairment
• Heart failure
• Diabetes mellitus
• Aortic or mitral valve stenosis
• Hypertrophic cardiomyopathy
• Surgery or anesthesia
• Pregnancy or breastfeeding

Additionally, be aware of the following precautions:

• Hypotension: Co-Amlessa can cause a sudden drop in blood pressure, especially at the beginning of treatment.
• Electrolyte disturbances: This medication can cause electrolyte imbalances (particularly low potassium levels). Regular monitoring of electrolyte levels is essential.
• Angioedema: A rare but potentially life-threatening side effect characterized by swelling of the face, lips, tongue, or throat.
• Ethnic characteristics: Perindopril may have a less pronounced hypotensive effect in black patients.
• Elderly patients: Elderly patients are more sensitive to the effects of this drug and may require dose adjustments.

Conclusion

Co-Amlessa is a potent triple-combination antihypertensive medication that can effectively lower blood pressure. However, it is essential to use this medication responsibly and under the guidance of a healthcare professional. This detailed guide provides information about dosage, side effects, drug interactions, and precautions associated with Co-Amlessa. Always consult with your doctor or pharmacist for personalized advice and guidance.