Zerkalin solution for external use 10mg/ml 30ml №1

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Mirror
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Colorless transparent liquid with an odor of ethanol. The main active ingredient is clindamycin. Release form Solution for external use Dosage 10 mg / ml in vial. 30ml Pharmacological properties Pharmacodynamics Clindamycin is an antibiotic of the lincosamide group, has a bacteriostatic or bactericidal effect, depending on the concentration at the site of application and the sensitivity of microorganisms. Clindamycin inhibits protein synthesis in sensitive microorganism cells by interacting with the 5OS subunits of ribosomes. The spectrum of action of clindamycin in vitro and in vivo includes most gram-positive bacteria, a number of anaerobic pathogens and protozoa. The most common indications for use are anaerobic staphylococcal and streptococcal infections, as well as the prevention of endocarditis. The mechanism of action of clindamycin in the treatment of acne is not fully understood, it is believed that it is based on the antibacterial activity of the drug. When the drug is applied to the skin, suppression of the growth of sensitive microorganisms, including strains of Propionibacterium acnes, found in the sebaceous glands and follicles, is observed, a decrease in the concentration of free fatty acids (FFA) in sebum is recorded. This effect is due to an indirect suppression of the activity of microorganisms that produce lipase, which is necessary for the conversion of triglycerides into FFA, or is a direct consequence of a decrease in the production of lipase by microorganisms. Clindamycin is active against all strains of Propionibacterium acnes, the minimum inhibitory concentration (MIC) is 0.4 μg / ml. After application to the skin, the amount of free fatty acids on the surface of the skin is reduced from about 14 to 2%. Pharmacokinetics Clindamycin rapidly accumulates in comedones, where it exhibits antibacterial activity. The average concentration of the antibiotic in the content of comedones after applying the solution significantly exceeds the minimum inhibitory concentration for all strains of Propionibacterium acnes, the causative agent of acne. The bioavailability of clindamycin after application to the skin is about 7.5%. At the same time, very low concentrations of clindamycin are determined in the blood plasma and urine. Indications for use The drug is used to treat acne (acne vulgaris). Dosage and administration Externally. The solution is applied to the affected area of previously cleansed and dried skin 2 times a day, morning and evening. Course of treatment: to obtain satisfactory results, treatment should be continued for 6-8 weeks, the maximum effectiveness of the drug is observed after 12 weeks of use. Use in children The safety and efficacy of the drug in children under 12 years of age have not been established, therefore, the drug is not prescribed for children in this age group. Use in Elderly Patients A number of clinical studies have not revealed any specific use of the drug in elderly patients compared with younger patients. Application during pregnancy and lactation. External use of the solution during pregnancy is possible if the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, use during lactation is recommended to stop breastfeeding. Influence on the ability to drive a car and operate other mechanisms 1% solution of clindamycin does not affect the ability to drive a car and operate other mechanisms. Precautions Age up to 12 years, lactation period. Caution should be used in patients with allergies, as well as while taking muscle relaxants. Topical application of clindamycin can lead to the growth of resistant organisms (gamma-negative folliculitis). If an infection occurs during treatment with clindamycin, treatment should be discontinued and adequate therapy instituted. A possible systemic effect of clindamycin may lead to adverse effects from the gastrointestinal tract (including pseudomembranous colitis). The patient should stop using clindamycin and consult a doctor if a symptom such as diarrhea occurs with topical application of the drug. When using the drug, contact of the drug with the eyes and mouth should be avoided, and after use, wash your hands. Propylene glycol, which is part of the drug Zerkalin, can cause skin irritation. The drug contains ethanol, which can cause burning and irritation of the mucous membranes of the eyes. In case of accidental contact with eyes, damaged skin or mucous membranes, rinse thoroughly with cool water. Clindamycin topical solution has an unpleasant taste and should be applied with care in the mouth area. Interaction with other drugs The simultaneous use of clindamycin hydrochloride with other drugs for the treatment of acne, containing exfoliating, softening and abrasive substances (for example, benzoyl peroxide, tretinoin, resorcinol, salicylic acid, sulfur) is not recommended due to the possible cumulative irritant effect on the skin. Clindamycin and erythromycin are antagonists, as a result of which the simultaneous use of these antibiotics is not recommended. Cross-resistance exists between clindamycin and lincomycin. Clindamycin may enhance the effect of muscle relaxants by interfering with neuromuscular transmission. In patients treated with clindamycin in combination with vitamin K antagonists (warfarin, acenocoumarol, fluindione), there was a change in blood coagulation parameters (increased PT / INR values). In this regard, patients taking vitamin K antagonist preparations should regularly evaluate the state of the blood coagulation system. Contraindications Hypersensitivity to clindamycin or lincomycin, as well as to other components of the drug in history; history of inflammatory bowel disease or antibiotic-associated colitis. Composition 100 ml of the drug contains Active ingredient: 1.14 g of clindamycin hydrochloride (equivalent to 1 g of clindamycin) Excipients: ethyl alcohol 96% – 60.80 g; propylene glycol – 8.69 g; purified water – 17.37 g. In case of overdose, symptomatic treatment is carried out. Side effects The drug is usually well tolerated, however, with topical application of the solution, irritation (at the site of application), burning, itching, dry skin, erythema, peeling, increased sebum secretion, contact dermatitis is possible. Gastrointestinal disorders, abdominal pain, eye irritation, folliculitis, hypersensitivity reactions, urticaria may occur. With resorption, there is a possibility of developing pseudomembranous enterocolitis. Very rarely, the development of a neuromuscular blockade can be observed. If the listed adverse reactions occur, as well as reactions not listed in the instructions for medical use, you should consult a doctor. Storage conditions Store in a place protected from moisture and light, out of the reach of children, at a temperature not exceeding 25°C. Buy Zerkalin solution for external use 10mg/ml 30ml №1 Price for Zerkalin solution for external use 10mg/ml 30ml №1Instruction for use for Zerkalin solution for external use 10mg/ml 30ml №1