Vitamin E capsules 100ME №15×2

NameVitamin E caps.100IU. Release formCapsules. Dosage 100 IU. 30 pieces per pack Special instructions In newborns with low body weight, hypovitaminosis E may occur due to low permeability of the placenta (the blood of the fetus contains only 20-30% of vitamin E from its concentration in the mother’s blood). A diet high in selenium and sulfur-containing amino acids reduces the need for vitamin E. When prescribing vitamin E to newborns, the benefits should be weighed against the potential risk of necrotizing enterocolitis. Currently, the effectiveness of vitamin E is considered unreasonable in the treatment and prevention of the following diseases: beta-thalassemia, cancer, fibrocystic breast dysplasia, inflammatory skin diseases, hair loss, recurrent miscarriage, heart disease, “intermittent” claudication, postmenopausal syndrome , infertility, peptic ulcer, sickle cell anemia, burns, porphyria, neuromuscular conduction disorders, thrombophlebitis, impotence, bee stings, senile lentigo, bursitis, diaper dermatitis, pulmonary intoxication due to air pollution, atherosclerosis, aging. The use of vitamin E to increase sexual activity is considered unproven. Tocopherols are found in the green parts of plants, especially in young cereal sprouts; large amounts of tocopherols are found in vegetable oils (sunflower, cottonseed, corn, peanut, soybean, sea buckthorn). Some of them are found in meat, fat, eggs, milk. Warnings Caution should be used in severe cardiosclerosis, myocardial infarction, with an increased risk of thromboembolism, as well as hypoprothrombinemia (against a background of vitamin K deficiency – may increase with a dose of vitamin E over 400 IU). Pharmacological properties Pharmacodynamics Vitamin E is an antioxidant agent, participates in the processes of cell proliferation, tissue metabolism, prevents hemolysis of erythrocytes, prevents increased permeability and fragility of capillaries. The drug prevents the development of atherosclerosis, degenerative-dystrophic changes in the heart muscle and skeletal muscles, improves nutrition and myocardial contractility, reduces myocardial oxygen consumption. It inhibits free radical reactions, prevents the formation of peroxides that damage cellular and subcellular membranes. Stimulates the synthesis of heme and heme-containing enzymes – hemoglobin, myoglobin, cytochromes, catalase, peroxidase. Improves tissue respiration, stimulates protein synthesis (collagen, enzymatic, structural and contractile proteins of skeletal and smooth muscles, myocardium), protects vitamin A from oxidation, inhibits cholesterol synthesis. It inhibits the oxidation of unsaturated fatty acids and selenium (a component of the microsomal electron transport system). In the absence of vitamin E in the body (avitaminosis E), degenerative changes develop in the skeletal muscles of the heart, capillary permeability and fragility increase, the epithelium of the seminiferous tubules and testicles is reborn. Embryos have hemorrhages, their intrauterine death occurs. Degenerative changes in nerve cells and damage to the liver parenchyma were also established. With vitamin E deficiency, there is a decrease in the concentration of proteins in the blood serum and the content of nucleic acids in the liver and testicles. Vitamin E deficiency in humans may be associated with nutritional characteristics (for example, lack of vegetable fats in food) or due to various diseases, such as liver, pancreas, etc. Pharmacokinetics Approximately 50% of the administered dose is absorbed from the gastrointestinal tract, the maximum level in the blood is created after hours. Absorption requires the presence of bile acids, fats, normal pancreatic function. In the process of absorption, it forms a complex with lipoproteins, which are intracellular carriers of vitamin E. It enters mainly into the lymph, then into the general circulation, where it binds mainly to alpha1 and beta-lipoproteins, and partially to serum albumin. If protein metabolism is disturbed, transport is hindered. It is deposited in all organs and tissues, especially in adipose tissue. It undergoes metabolism in the liver to derivatives having a quinone structure (some of them have vitamin activity). Excreted in bile (over 90%) and urine (about 6%) unchanged and as metabolites. Indications for use Vitamin E (Tocopherol) is used for hypovitaminosis, convalescence after diseases that occur with a febrile syndrome, asthenic and neurasthenic syndrome, degenerative and proliferative changes in the joints, diseases of the ligamentous apparatus and muscles; dysfunction of the gonads in men; in women – with various violations of the menstrual cycle, with a deterioration in the conditions of intrauterine development of the fetus. Tocopherol is indicated for newborns, premature or low birth weight, young children with insufficient intake of vitamin E from food. Newborns with low body weight: to prevent the development of hemolytic anemia, bronchopulmonary dysplasia, complications of retrolental fibroplasia. Vitamin E is used for lesions of peripheral vessels (endarteritis, Raynaud’s disease), spasms of peripheral vessels. Vitamin E is also prescribed for seborrhea, atrophic skin changes (scleroderma, etc.), trophic ulcers of the lower leg, photodermatosis, psoriasis, dermatomyositis, and other collagenoses. Alpha-tocopheryl acetate is also indicated for necrotizing myopathy, abetalipoproteinemia, gastrectomy, chronic cholestasis, liver cirrhosis, biliary atresia, obstructive jaundice, celiac disease, tropical sprue, Crohn’s disease, malabsorption, parenteral nutrition, pregnancy (especially multiples), menopause, nicotine addiction , drug addiction, during lactation, when taking cholestyramine, colestipol, mineral oils and iron-containing products, when prescribing a diet with a high content of polyunsaturated fatty acids. See vitamin E capsules for instructions. Dosage and administration Vitamin E instructions for use (Tocopherol instructions for use), vitamin E capsules instructions for use. In case of violation of spermatogenesis, men are prescribed 100-300 mg (100-300 IU) of alpha-tocopheryl acetate per day (in combination with hormone therapy) for a month; in case of deterioration of the conditions of intrauterine development of the fetus – 100-200 mg (100-200 IU) during the first 2-3 months of pregnancy daily or every other day. With muscular dystrophies, amyotrophic lateral sclerosis, dermatomyositis and other collagenoses, vitamin E is used at 100 mg (100 IU) per day for 1-2 months; repeated courses are prescribed in 2-3 months; in diseases of peripheral vessels – 100 mg (100 IU) per day (in combination with vitamin A) for 20-40 days, after 3-6 months the course of treatment can be repeated. For skin diseases, the drug is prescribed at a dose of 100 mg (100 IU) per day for 20-40 days. The duration of treatment for hypovitaminosis E is individual and depends on the severity of the condition. If necessary, the dose can be increased to 1 g (1000 IU) per day. It is not recommended to prescribe for a long time together with other multivitamin preparations, because. an overdose of fat-soluble vitamin E is possible. Use during pregnancy and lactation Vitamin E is used during pregnancy and during breastfeeding according to indications. Vitamin E crosses the placenta in insufficient quantities: 20-30% of the concentration in the mother’s blood penetrates into the blood of the fetus. Penetrates into breast milk. In premature and newborn babies, its cumulation is possible. Interaction with other drugsTocopherol increases the effectiveness of anticonvulsants in patients with epilepsy who have an increased content of lipid peroxidation products in the blood. Enhances the effect of steroid and non-steroidal anti-inflammatory drugs, antioxidants. Increases the effectiveness and reduces the toxicity of cardiac glycosides, as well as vitamins A and D. The appointment of vitamin E in high doses can cause a deficiency of vitamin A in the body. The simultaneous use of vitamin E at a dose of more than 400 IU / day with anticoagulants (coumarin and indandione derivatives) increases the risk of hypoprothrombinemia and bleeding. Colestyramine, colestipol, mineral oils reduce the absorption of alpha-tocopheryl acetate. High doses of iron enhance oxidative processes in the body, which increases the need for vitamin E. With the simultaneous use of alpha-tocopheryl acetate with cyclosporine, the absorption of the latter increases. Contraindications hypersensitivity; cardiosclerosis; myocardial infarction. The composition of alpha-tocopheryl acetate – 100 mg (100 IU). Overdose Symptoms: when taken for a long period in doses of 400 – 800 IU / day – blurred vision, dizziness, headache, nausea, extreme fatigue, diarrhea, gastralgia, asthenia; when taking more than 800 IU / day for a long period – an increase in the risk of bleeding in patients with hypovitaminosis K, impaired metabolism of thyroid hormones, sexual dysfunction, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, hemorrhages in the retina the membrane of the eye, hemorrhagic stroke, ascites, hemolysis. Treatment: drug withdrawal; prescribe glucocorticoids that accelerate the metabolism of vitamin E in the liver; Vikasol is prescribed to reduce the risk of hemorrhages. Side effects Allergic reactions. When taking large doses – diarrhea, epigastric pain, creatinuria. If side effects occur, the dose of the drug should be reduced or discontinued. See vitamin e capsules for instructions. Storage conditions Do not use after the expiry date stated on the packaging. Store in a place protected from moisture and light at a temperature of 15°C to 25°C. Stored out of the reach of children. Buy Vitamin E capsules 100ME No. 15×2 Price for Vitamin E capsules 100ME No. 15×2