Vermacar tablets 100mg №6×1

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Vermakar tabl 100mg in a blister. in pack. No. 6×1
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Tablets from white to almost white, round, with a dividing line on one side and the Pharmakar logo on the other side, with a peculiar smell, marbling is allowed. The main active ingredient mebendazole Release form Tablets Dosage 100 ml Special instructions A study of one case of the development of Stevens-Johnson syndrome / toxic epidermal necrolysis in a patient suggested a possible relationship between the simultaneous administration of metronidazole and mebendazole and the development of this severe adverse reaction. Although there is no additional supporting evidence for this potential interaction, concomitant administration of metronidazole and Vermacar should be avoided. You should avoid the simultaneous use of Vermakar with alcohol (alcohol during the day after taking Vermakar) and laxatives, as well as lipophilic substances. Fatty foods increase the absorption of mebendazole. With prolonged use, it is necessary to monitor peripheral blood carchina, the functional state of the liver and kidneys. Influence on the ability to drive vehicles and work with dangerous devices and mechanisms There are no data on adverse effects. Indications for use enterobiasis; ascariasis; hookworm; strongyloidiasis; trichuriasis; multiple nematodes; taeniasis; mixed helminthiases. Dosage and administration Vermakar is administered orally before or after meals. If the drug is taken in tablets, then they should be chewed before swallowing. With enterobiasis, vermacar is prescribed at a dose of 100 mg once. Children over 2 years of age and adults are given the same dose. To prevent re-invasion, the drug is repeated after 2 and 4 weeks at the same dose. Conduction is recommended, simultaneous treatment of the whole family. In case of ascariasis, trichocephalosis, ankylostomidosis or mixed invasions, Vermakar is prescribed for adults and children over 2 years old, 100 mg 2 times a day (morning and evening) for 3 days. With teniosis and strongyloidiasis, adults are recommended to take 200 mg of Vermacar 2 times a day for 3 days. For children older than 2 years, the drug is prescribed 100 mg 2 times a day, also for 3 days. Use during pregnancy and lactation Use during pregnancy: The safety of the use of mebendazole during pregnancy has not been proven, although studies on different animal species have shown embryotoxic and teratogenic effects in rats. Based on this, the use of Vermocar is contraindicated during pregnancy. Use during lactation: There are no data on the penetration of mebendazole into breast milk, which does not allow an assessment of the degree of risk to the newborn. Taking the drug is contraindicated during the period of feeding or requires the cessation of breastfeeding. Interaction with other drugs Cimetidine: Cimetidine may inhibit the hepatic metabolism of mebendazole, which can lead to an increase in plasma and tissue concentrations of mebendazole. Carbamazepine and other inducers of hepatic metabolism: a decrease in tissue concentrations of mebendazole is possible due to the acceleration of hepatic metabolism. Metronidazole: concomitant use should be avoided. Laxatives: you should refrain from taking Vermacar at the same time. Contraindications History of hypersensitivity to mebendazole and other benzimidazoles. Pregnancy and breastfeeding (or cessation of breastfeeding for the period of treatment). Children under 2 years of age. Ingredients: mebendazole 100 mg Excipients: lactose monohydrate, starch, avicel PH 101, magnesium stearate, plasdon K 29/32. Overdose Symptoms: in case of accidental overdose, abdominal cramps, nausea, vomiting, diarrhea have been observed. With prolonged use in high doses, reversible liver dysfunction, hepatitis, neutropenia are possible. Treatment: There is no specific antidote. During the first hour after taking an excess amount of mebendazole, it is recommended to carry out gastric lavage with an aqueous solution of potassium permanganate at a concentration of 20 mg / 100 ml. Perhaps the appointment of activated charcoal. Side effects When taken at recommended doses, Vermacar is well tolerated. When taking mebendazole, the following adverse reactions were observed: very frequent (> 1/10), frequent (> 1/100, < 1/10), infrequent (> 1/1000, < 1/100), rare (> 1/10000, < 1/1000), very rare (< 1/10000) including isolated cases. Blood and lymphatic system: very rarely neutropenia (with prolonged use at doses significantly higher than recommended), eosinophilia, decreased hemoglobin levels. Immune system: very rare hypersensitivity reactions such as anaphylactic and anaphylactoid reactions. Central nervous system: dizziness, headache. Gastrointestinal tract: very rarely, abdominal pain, diarrhea (these symptoms may be a manifestation of the helminthic invasion itself). Hepato-biliary system: very rarely hepatitis and with prolonged use in doses significantly exceeding the recommended deviations of liver function parameters (ALT, ACT, alkaline phosphatase). Body as a whole: very rarely toxic epidermal necrolysis, Stevens-Johnson syndrome; rarely exanthema, angioedema, urticaria, rash. Kidneys and urinary system: very rarely glomerulonephritis (with prolonged use in doses significantly higher than recommended). Storage conditions Store in a place protected from moisture and light at a temperature not exceeding t-25°C. Keep out of the reach of children. Buy Vermacar tablets 100mg №6x1