Sorbifer Durules tablets p/o 320mg/60mg №50 №1

Name:
Sorbifer Durules No. 50
Description:
Light yellow film-coated tablets, round, biconvex, engraved with “Z” on one side; at the break – the core is gray, with a characteristic odor. The main active ingredient is Ascorbic acid, Ferrous sulfate Release form: Tablets, light yellow, film-coated, round, biconvex, engraved with “Z” on one side; at the break – the core is gray, with a characteristic odor. 1 tab. iron sulfate (II) 320 mg, equivalent to the content of Fe2+ 100 mg ascorbic acid (vit. C) 60 mg Excipients: magnesium stearate, povidone K-25, polyethylene powder, carbomer 934R. Coating composition: hypromellose, macrogol 6000, titanium dioxide, yellow iron oxide, hard paraffin. 30 pcs. – dark glass bottles (1) – packs of cardboard. 50 pcs. – dark glass bottles (1) – packs of cardboard. Dosage No. 50 Special instructions When using the drug, darkening of the feces is possible, which has no clinical significance. Pharmacological action Iron is an indispensable component of the body, necessary for the formation of hemoglobin and the occurrence of oxidative processes in living tissues. The drug is used to eliminate iron deficiency. Durules technology provides a gradual release of the active ingredient (iron ions) over a long time. The plastic matrix of Sorbifer Durules tablets is completely inert in the digestive juice, but completely disintegrates under the action of intestinal peristalsis when the active ingredient is completely released. Ascorbic acid improves iron absorption. PharmacokineticsDurules absorption is a technology that provides a gradual release of the active substance (iron ions), a uniform intake of the drug. Taking 100 mg 2 times / day provides a 30% greater absorption of iron from the drug Sorbifer Durules compared to conventional iron preparations. Absorption and bioavailability of iron are high. Iron is absorbed predominantly in the duodenum and proximal jejunum. Distribution Communication with plasma proteins – 90% or more. It is deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the system of phagocytic macrophages, a small amount – in the form of myoglobin in muscles. Withdrawal T1 / 2 is 6 hours. Indications for use – iron deficiency anemia; – iron deficiency; – prophylactic use during pregnancy, lactation, in blood donors. Dosage and administration I take the drug orally. Coated tablets should not be divided or chewed. The tablet should be swallowed whole and washed down with at least half a glass of liquid. Adults and adolescents are prescribed 1 tab. 1-2 times / day. If necessary, for patients with iron deficiency anemia, the dose can be increased to 3-4 tablets / day in 2 divided doses (morning and evening) for 3-4 months (until the iron depot in the body is replenished). During pregnancy and lactation, for the purpose of prevention, appoint 1 tablet / day; for treatment appoint 1 tab. 2 times / day (morning and evening). Treatment should be continued until the optimal hemoglobin level is reached. For further replenishment of the depot, it may be necessary to continue taking the drug for another 2 months. Use during pregnancy and lactation It is possible to use the drug Sorbifer Durules during pregnancy and lactation according to indications. Precautions The drug should be used with caution in gastric and duodenal ulcers, inflammatory bowel diseases (enteritis, diverticulitis, ulcerative colitis, Crohn’s disease). Interaction with other drugs Sorbifer Durules may reduce the absorption of concomitantly used enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines and thyroid hormones. The simultaneous use of the drug Sorbifer Durules and antacids containing aluminum hydroxide and magnesium carbonate may reduce the absorption of iron. Between taking the drug Sorbifer Durules and any of these drugs should withstand the maximum possible time interval. The recommended minimum interval between doses is 2 hours, except when taking tetracyclines, when the minimum interval should be 3 hours. Sorbifer Durules should not be combined with the following drugs: ciprofloxacin, doxycycline, norfloxacin and ofloxacin. Contraindications – stenosis of the esophagus and / or other obstructive changes in the digestive tract; – increased iron content in the body (hemosiderosis, hemochromatosis); – violation of iron utilization (lead anemia, sideroblastic anemia, hemolytic anemia); – children’s age up to 12 years (due to lack of clinical data); – Hypersensitivity to the components of the drug. Composition 1 tab. iron sulfate (II) 320 mg, equivalent to the content of Fe2+ 100 mg ascorbic acid (vit. C) 60 mg Excipients: magnesium stearate, povidone K-25, polyethylene powder, carbomer 934R. Coating composition: hypromellose, macrogol 6000, titanium dioxide, yellow iron oxide, hard paraffin. 50 pcs. – dark glass bottles (1) – packs of cardboard. Overdose Symptoms: abdominal pain, vomiting and diarrhea mixed with blood, fatigue or weakness, hyperthermia, paresthesia, pallor of the skin, cold clammy sweat, acidosis, weak pulse, decreased blood pressure, palpitations. In severe overdose, signs of peripheral circulatory collapse, coagulopathy, hyperthermia, hypoglycemia, liver damage, renal failure, muscle cramps and coma may occur after 6-12 hours. Treatment: in case of overdose, immediately consult a doctor. It is necessary to wash the stomach, inside – a raw egg, milk (to bind iron ions in the digestive tract); administer deferoxamine. Symptomatic therapy. Side effect On the part of the digestive system: nausea, vomiting, abdominal pain, diarrhea, constipation (the frequency of these side effects may increase with increasing doses from 100 mg to 400 mg); rarely (<1/100) - ulcerative lesions of the esophagus, stenosis of the esophagus. Allergic reactions: rarely (<1/100) - itching, rash. From the side of the central nervous system: rarely (<1/100) - headache, dizziness. Other: rarely (<1/100) - hyperthermia of the skin, weakness. text Storage conditions The drug should be stored out of the reach of children at a temperature of 15° to 25°C. Buy Sorbifer Durules tablets p/o 320mg/60mg №50 №1 Price for Sorbifer Durules tablets p/o 320mg/60mg №50 №1