Prefemin tablets p/o 20mg №30×1

Product DescriptionPrefemin. Release form Tablets. Composition 1 tablet contains: active substance: 20 mg of dry native extract of the fruits of the common plantain (Agnus castus fruit) (6-12:1), extractant – ethanol 60% (m / m), excipients: microcrystalline cellulose, lactose monohydrate, magnesium stearate , anhydrous colloidal silicon dioxide, shell: hypromellose, titanium dioxide (E 171), macrogol 400, macrogol 20000, propylene glycol. DescriptionPills are round, biconvex, film-coated, white, with a fragrant odor. Pharmacotherapeutic group Other drugs used in gynecology. The fruits of the common prutnyak. ATX code G02CX03 Pharmacological properties The main active ingredient of the medicinal product is the common rod (Agnus castus). Dopaminergic effects of the drug, causing a decrease in prolactin production, eliminate hyperprolactinemia. An increased concentration of prolactin disrupts the secretion of gonadotropins, as a result of which disturbances in the maturation of follicles, ovulation and the formation of the corpus luteum may occur, which further leads to an imbalance between estradiol and progesterone and can cause menstrual irregularities, as well as mastodynia. Unlike estrogens and other hormones, prolactin also has a direct stimulating effect on the proliferative processes in the mammary glands, enhancing the formation of connective tissue and causing the expansion of the milk ducts. A decrease in the content of prolactin leads to the reverse development of pathological processes in the mammary glands and relieves pain. The rhythmic production and normalization of the ratio of gonadotropic hormones leads to the normalization of the second phase of the menstrual cycle. Pharmacodynamic properties In the literature, it has been reported that water-alcohol extracts of the common plantain (Agnus castus) inhibit the release of prolactin in vitro. An action aimed at inhibiting the release of prolactin has also been observed in animal experiments. Conducted clinical studies have shown that the administration of an extract of the common rod (Agnus castus) to women with moderate signs of elevated prolactin concentrations or with increased release of prolactin under stress (so-called “latent hyperprolactinemia”) led to a decrease in prolactin levels. In vitro studies have shown that lactotropic pituitary cells are the site of action, with the mechanism of action being the dopaminergic principle. Bicyclic diterpenes have been identified as a group of substances that contribute to the action of the chamomile extract in reducing prolactin levels. These substances bind to the human dopamine receptor subtype 2 and dose-dependently decrease prolactin release in cultured rat pituitary cells. Pharmacokinetics No data available. Indications for use Herbal remedy for the treatment of premenstrual syndrome and menstrual disorders (too frequent or too rare menstruation). Dosing and Administration The recommended dose of Prefemin is 1 tablet per day. The tablet is intended for oral administration, it should not be chewed or dissolved, but must be swallowed whole with a glass of water. To achieve the optimal effect of treatment, a duration of use of at least three months is recommended. In the absence of the expected therapeutic effect, it is necessary to consult with your doctor about the advisability of further therapy with this remedy. Side effectsEstimation of side effects is based on the following data on the frequency of their occurrence: very common (≥1/10), frequent (≥ 1/100 and <1/10), infrequent (≥ 1/1000 and <1/100), rare ( ≥ 1/10,000 and < 1/1,000), very rare (< 1/10,000), frequency unknown (cannot be estimated from the available data). Nervous system disorders Frequency unknown: headache, dizziness. Respiratory, thoracic and mediastinal disorders Not known: Dyspnea. Gastrointestinal disorders Frequency unknown: Nausea, abdominal pain, difficulty swallowing. Skin and subcutaneous tissue disorders The following adverse reactions have been reported: systemic hypersensitivity reactions with rash (including exanthema); hives; angioedema; itching; acne. There are reports of rare cases of transient psychosomatic agitation, confusion and hallucinations. If signs of a hypersensitivity reaction appear, it is necessary to discontinue the drug and consult a doctor. Contraindications hypersensitivity to the active ingredient or any of the excipients of the drug; pituitary tumor; breast carcinoma. Interaction with other medicinal products Due to the possible dopaminergic and estrogenic effect of the fruits of Prutnyak ordinary, interaction with dopamine agonists and antagonists, estrogens and antiestrogens cannot be excluded. Warnings and Precautions Patients who suffer or have suffered from estrogen-sensitive cancer should consult their physician before using Chamois vulgaris. Patients who use dopamine agonists, dopamine antagonists, estrogens and antiestrogen should consult their physician before using Prutnyak vulgaris (see section "Interaction with other medicinal products"). The use in children and adolescents under the age of 18 years has not been established due to the lack of sufficient data. If symptoms worsen while using the medicine, consult your doctor or pharmacist. Prutnyak fruit is believed to act on the hypothalamic-pituitary axis and, therefore, patients with a pituitary history should consult a physician before use. In cases of prolactin-secreting pituitary tumors, the use of Prutnyak fruits may mask the manifestation of cancer symptoms. Use during pregnancy or lactation There are no indications for use during pregnancy. Data obtained from reproductive studies suggest that extracts of the fruit of the Prutnyak vulgaris may affect lactation. Not recommended for use during breastfeeding. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms Relevant studies have not been conducted. Overdose In case of overdose, the side effects listed in the "Side Effects" section may appear with increased intensity. If signs of allergic exanthema with vesiculation (formation of vesicles on the skin) appear, it is necessary to cancel the drug and consult a doctor. Release form and packaging 30 tablets in a blister pack made of PVC / PVDC and aluminum foil. 1 or 3 blister packs together with instructions for medical use are placed in a cardboard box. Storage conditions Store at a temperature not exceeding 25°C in the original packaging. Keep out of the reach of children. Shelf life 3 years After the expiration date, the drug should not be used. Terms of dispensing from pharmaciesWithout a prescription. Buy Prefemin tablets p/o 20mg №30x1 Price for Prefemin tablets p/o 20mg №30x1