Polyoxidonium tablets 12mg №10×1

Name Polyoxidonium tabl. The risks are designed to be broken to facilitate swallowing. The main active ingredient Azoximer bromide Release form tablets Dosage 12 mg Pharmacological properties Pharmacodynamics Polyoxidonium, tablets, 12 mg has an immunomodulatory effect. The drug increases the body’s resistance to bacterial, fungal and viral infections. The basis of the mechanism of the immunomodulatory action of Polyoxidonium is an increase in the ability of leukocytes to phagocytize microbes, to stimulate the production of cytokines that activate the immune system at initially low rates, and to enhance antibody formation to infectious agents. Polyoxidonium activates peripheral blood phagocytes and tissue macrophages, which contributes to more rapid elimination of the pathogen from the body in the presence of a focus of infection. In addition, Polyoxidonium activates lymphoid cells located in the regional lymph nodes, namely B cells that produce secretory IgA. When administered sublingually, Polyoxidonium activates lymphoid cells located in the nasal cavity, Eustachian tubes, oropharynx, and bronchi. In addition, Polyoxidonium® activates the bactericidal properties of saliva. When administered orally, Polyoxidonium® also activates lymphoid cells located in the intestinal lymph nodes. The consequence of this is an increase in the resistance of the respiratory, gastrointestinal tract and ENT organs to infectious agents. Along with the immunomodulating effect, Polyoxidonium has a pronounced detoxification and antioxidant activity, has the ability to remove toxins, heavy metal salts from the body, and inhibits lipid peroxidation. These properties are determined by the structure and high molecular nature of Polyoxidonium. The use of Polyoxidonium against the background of secondary immunodeficiency states can increase the effectiveness and reduce the duration of treatment, significantly reduce the use of antibiotics, bronchodilators, glucocorticosteroids, and lengthen the period of remission. The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have an allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effect. Pharmacokinetics Polyoxidonium, tablets, 12 mg after oral administration is rapidly “absorbed from the gastrointestinal tract, bioavailability is approximately 50%. The maximum plasma concentration is reached 3 hours after ingestion. The pharmacokinetics of Polyoxidonium is linear (plasma concentration is proportional to the dose taken). Polyoxidonium is a hydrophilic compound. The apparent volume of distribution is approximately 0.5 l / kg, which indicates that the drug is distributed mainly in the interstitial fluid. The half-life is 35 minutes, the half-life is 18 hours. In the body, it is hydrolyzed to oligomers, which are excreted mainly by the kidneys. There is no cumulative effect. Indications for use Polyoxidonium, tablets, 12 mg is used in adults and adolescents over 12 years of age in the complex therapy of acute respiratory infectious and inflammatory diseases. Dosage and administration Polyoxidonium, tablets, 12 mg is administered sublingually and orally 20-30 minutes before meals daily, for 10-14 days, 1-3 times a day. Adults: 1 tablet 1-3 times a day. Adolescents from 12 years: 1 tablet 1 time per day. The dosage regimen and duration of therapy is determined by the doctor depending on the severity of the process. Use during pregnancy and lactation The use of the drug Polyoxidonium is contraindicated in pregnant women and women during breastfeeding (clinical experience is not available). With the experimental use of the drug Polyoxidonium in animals, no embryotoxic and teratogenic effects, effects on the development of the fetus were detected. Before using the drug Polyoxidonium, if you are pregnant, or think that you could be pregnant, or are planning to become pregnant, you should consult your doctor. Precautions Before using the drug, consult your doctor. Read the instructions for use of the drug and save it. Strictly follow the instructions given in the instructions when taking the drug. If you have any questions, ask your doctor or pharmacist for clarification. If it is necessary to stop therapy with the drug, cancellation can be carried out immediately. In case of missing a single dose of the drug, it is necessary to take it as soon as possible, but if it is time for the next dose, do not increase the dose. Do not use the drug if there are visual signs of its unsuitability (packaging defect, discoloration of the tablets). If the symptoms of the disease worsen or new symptoms appear during the use of the drug, it is recommended to consult a doctor. Lactose: Patients with rare hereditary problems of galactose intolerance, the lactase deficiency or glucose-galactose malabsorption should not take this medicinal product. If it is necessary to stop therapy with the drug, cancellation can be carried out immediately. If you suffer from any chronic diseases, before using Polyoxidonium, seek the advice of a doctor. Interaction with other drugs No drug interaction has been established. It is possible to simultaneously use Polyoxidonium® with many drugs, including antibiotics, antiviral, antifungal and antihistamine drugs, bronchodilators, glucocorticosteroids, cytostatics, ?-adrenergic agonists. Contraindicationsindividual hypersensitivity; hereditary fructose intolerance, Lapp-lactase deficiency, glucose-galactose malabsorption; acute renal failure; pregnancy and breastfeeding (no clinical experience); children’s age up to 12 years. Active ingredient: Azoximer bromide – 12 mg; Excipients: mannitol – 3.6 mg, povidone – 2.4 mg, lactose monohydrate – 185.0 mg, potato starch – 45.0 mg, stearic acid – 2.0 mg. Overdose Cases of abuse and overdose of Polyoxidonium have not been registered. Side effects No side effects have been reported. If you notice any side effects, tell your doctor about it. Storage conditions At temperatures from 2 to . Keep out of the reach of children. Buy Polyoxidonium tablets 12mg №10×1 Price for Polyoxidonium tablets 12mg №10×1 Instructions for use for Polyoxidonium tablets 12mg №10×1