Pirantel oral suspension 250mg/5ml 20ml №1

Name:
Pyrantel suspension 250mg 5ml 20ml in pack No. 1
Description:
Light yellow suspension with a characteristic odor. The main active ingredientPyrantel Release formSuspension Dosage 20ml Pharmacological propertiesPyrantel is an anthelmintic agent that acts on nematodes. It acts on the muscles of intestinal nematodes by depolarizing their neuromuscular junction and blocking the action of cholinesterase. Immovable parasites are removed from the intestines due to peristaltic movements. Does not irritate or cause worm migration. It acts on mature forms and parasites at an early stage of development, but does not act on larvae during their migration in tissues. The drug is used primarily for infections with pinworms (Enterobius vermicularis) and roundworms (Ascaris lumbricoides). Can be used for hookworm infection; more effective in treating duodenal hookworm (Ancylostoma duodenale) infections than American hookworm (Necator americanus) infections. After oral administration, the drug is poorly absorbed from the digestive tract. After oral administration, it reaches very low plasma concentrations, at the limit of detection. After taking a single dose of the drug at 11 mg/kg body weight, the maximum plasma concentration achieved after 1-5 hours (Tmax) ranged from 0 µg/ml to 0.1 µg/ml. There are no data on the penetration of the drug through the placenta and into the milk of a nursing woman. The minimum amount of the drug resorbed from the digestive tract is partially metabolized in the liver to N-methyl-1,3-propanediamine. About 93% of an oral dose of the drug is excreted unchanged in the feces and no more than 7% is excreted in the urine in unchanged form or in the form of metabolites. Indications for use Enterobiasis Ascariasis Ankylostomidosis Necatoriasis Method of administration and doses Method of administration The drug should be taken orally, during or after meals, with water. Shake before use until a homogeneous suspension is obtained. There is no need to take laxatives before using Pirantel. A graduated measuring cup is included with the package for easy dosing. 5 ml of suspension (1 scoop) contains 250 mg of pyrantel. Recommended dose in adults and children weighing more than 10 kg For ascariasis Adults and children weighing > 10 kg: a single dose of 11 mg/kg. Usually a single dose is prescribed, but if there is no effect, the dose should be repeated after 2 or 3 weeks. For enterobiasis Adults and children weighing > 10 kg: 11 mg/kg single dose. This dose of the drug should be repeated after 2 or 3 weeks. For invasion by duodenal hookworm or necator Adults and children weighing > 10 kg: 11 mg/kg once daily for 3 days. Dosage in patients with impaired liver function In the case of existing liver disease, the doctor should be informed. Dosing in patients with impaired renal function In the case of existing kidney disease, the doctor should be informed. Use during pregnancy and lactation Adequate and strictly controlled safety studies of the use of pyrantel during pregnancy and lactation (breastfeeding) have not been conducted. The use of the drug during these periods is possible only if absolutely necessary, if the intended benefit to the mother outweighs the potential risk to the fetus or child, and only under strict medical supervision. Precautions Use of the drug in the elderly There is no information on the effect of age on the action of Pirantel in geriatric patients. Influence on the ability to drive vehicles and control mechanisms Given the possible side effects from the nervous system (dizziness, headache, etc.), during the use of the drug, care must be taken when engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions . Interaction with other drugs May increase the concentration of theophylline in plasma. The simultaneous use of piperazine inhibits the action of pyrantel. Contraindications Hypersensitivity to pyrantel or other components of the drug. Myasthenia gravis (treatment period). Simultaneous use of piperazine. Active ingredient: pyrantel 0.750 g/15 ml (in the form of pyrantel embonate 2.1625 g/15 ml). excipients: sodium benzoate, sodium carboxymethylcellulose, sorbitol 70% (E420), glycerol, magnesium aluminum silicate, polysorbate 80, povidone, apricot flavor, antifoam, citric acid, sodium hydroxide, purified water up to 15 ml. Overdose After an overdose of the drug, the following symptoms may develop: visual disturbances, confusion, dizziness, fainting or feeling dizzy when rising from a lying or sitting position, increased sweating, previously not observed feeling of tiredness or weakness, irregular pulse, convulsions, tremors and muscle weakness, exhaustion , breathing problems, loss of consciousness. In case of intoxication, you should immediately consult a doctor. Side effects Side effects of pyrantel are rare and disappear after treatment is stopped. The frequency of adverse reactions is defined as follows: very frequent (? 1/10); frequent (? 1/100 and < 1/10); infrequent (? 1/1000 and < 1/100); rare (? 1/10 000 and < 1/1000), very rare (< 1/10 000), with an unknown frequency (cannot be estimated from the available data). Nervous system disorders: Rare: Headache, dizziness, drowsiness or insomnia Unknown: hallucinations, confusion, paresthesias Hearing and labyrinth disorders: Unknown: hearing impairment Gastrointestinal tract disorders: Rare Side effects: nausea, vomiting, abdominal pain, diarrhea and loss of appetite Unknown frequency: urge to defecate Liver and biliary tract disorders: Rare: transient increase in aminotransferases (enzymes that determine liver function). Skin and subcutaneous tissue disorders: Rare: rash General disorders and administration site disorders: Rare: fatigue. Frequency not known: hyperthermia. The appearance of all side (unusual) effects, including those not listed in the package insert, must be reported to the attending physician. Storage conditions Store at a temperature not exceeding 25 ° C, in the original packaging. Keep out of the reach of children. Buy Pirantel oral suspension 250mg/5ml 20ml №1