Name:
Neuromultivit. Forms of release Tablets. INNPolyvitamin. FTHPolyvitamin.
Description:
White or almost white tablets, film-coated, round and biconvex. Composition Active substances: One film-coated tablet contains: Thiamine hydrochloride (vitamin B1) – 100 mg, Pyridoxine hydrochloride (vitamin B6) – 200 mg, Cyanocobalamin (vitamin B12) – 0.2 mg. Excipients: pregelatinized starch, sodium citrate, citric acid monohydrate, anhydrous colloidal silicon dioxide, microcrystalline cellulose, magnesium stearate, povidone, macrogol 6000, titanium dioxide (E171), talc, hypromellose, dispersion polyacrylate 30%. Pharmacotherapeutic group Vitamins. Vitamin B1 in combination with vitamin B6 and/or B12. ATC code: A11DB Pharmacological properties Vitamin B1 (thiamine hydrochloride) takes part in carbohydrate metabolism and affects the functional state of the nervous system. Vitamin B6 (pyridoxine hydrochloride) induces the metabolism of amino acids in nerve tissues and affects the biosynthesis of many well-known mediators such as dopamine, adrenaline and norepinephrine. Vitamin B12 (cyanocobalamin) affects, in particular, the metabolism of fatty acids in nerve tissues and is essential for cell growth and replication. Indications for use Neurological disorders caused by deficiency of vitamins B1, B6 and B12, which cannot be eliminated by dietary modification. Contraindications Hypersensitivity to any of the components that make up the drug. Due to the high content of active substances, the drug should not be taken by persons under 18 years of age. Influence on the ability to drive vehicles or mechanisms Neuromultivit does not affect the ability to drive vehicles or mechanisms. Application during pregnancy and lactation Due to insufficient experience, it is not recommended to use Neuromultivit during pregnancy and lactation. Pregnancy The recommended daily intake of vitamin B1 during pregnancy and lactation is 1.7-1.8 mg, vitamin B6 2.3-2.5 mg, vitamin B12 3.5 mcg. These doses may only be exceeded during pregnancy if the patient has a proven deficiency of vitamins B1, B6, B12, since the safety of using doses above the daily recommended dose has not yet been proven. There are insufficient animal studies on effects on pregnancy, embryofetal and pre- and postnatal development of offspring. The potential risk to humans is unknown. Lactation Vitamins B1, B6 and B12 pass into breast milk. High concentrations (600 mg per day) of vitamin B6 can suppress milk production. Data on the degree of transition into milk in animals are not available. Interaction with other medicinal products and other types of interactionVitamin B6 may reduce the effectiveness of levodopa when used simultaneously. Thiamine is inactivated by 5-fluorouracil as a result of competitive inhibition of thiamine phosphorylation by the latter. With long-term treatment with furosemide, an increase in renal excretion of thiamine is possible. Isoniazid, cycloserine, D-penicillamine may reduce the effectiveness of vitamin B6 (pyridoxine). Antacids, alcohol and tea reduce the absorption of thiamine. Co-administration of pyridoxine antagonists (eg, isoniazid, hydralazine, D-penicillamine, or cycloserine) may decrease the effectiveness of vitamin B6. Sulfite-containing drinks (eg wine) contribute to the destruction of thiamine. Special instructions and precautions for use Inform your doctor immediately if you experience any side effects or if you are pregnant. Treatment with large doses of the drug for longer than 4 weeks is not recommended. When used in the elderly and in persons with impaired liver and / or kidney function, dose adjustment is usually not required. Dosing and Administration The usual dose is one tablet once a day. However, after prior consultation with a doctor, the dose may be increased to 1 tablet 3 times a day. Tablets should be swallowed without chewing after meals with a small amount of liquid. The course of treatment should not exceed 4 weeks, after which the attending physician must decide on further therapy. If you miss a tablet, take the next one at the usual time, do not double the dose to make up for the missed tablet. OverdoseVitamin B1 No cases of overdose are known. Thiamine has a wide therapeutic range. Very high intravenous doses (more than 10 g) have a ganglioblocking effect and curare-like suppression of neuronal impulse transmission. Vitamin B6 Taking more than 2 g (equivalent to 10 Neuromultivit tablets) daily can cause nervous system dysfunctions such as movement disorders, sensory disturbances (tingling, numbness), convulsions and EEG changes. In rare cases, anemia and rash. The toxic potential of vitamin B6 is considered very low. However, long-term use (more than 6-12 months) of daily doses of vitamin B6 of 50 mg causes the development of peripheral sensory neuropathy, these symptoms gradually decrease after the cessation of vitamin B6 intake. With continuous intake of vitamin B6 for more than 2 months, in doses above 1 g per day, neurotoxic side effects may occur. Vitamin B12 After parenteral administration of high doses (in rare cases and after oral administration), allergic reactions, eczema and acne are observed. Treatment for overdose: Treatment should be supportive and symptomatic. Side effects Like all medicines, Neuromultivit can cause side effects, although not everyone gets them. The following adverse reactions have been registered: – rarely (in less than one in 1000 patients): headache, dizziness, nausea. – very rare (less than one in 10,000 patients): hypersensitivity reactions, appearing mainly on the skin after the use of vitamin B1 or B12, itching, urticaria. – with an unknown frequency (cannot be estimated based on the available data): peripheral sensory polyneuropathy with prolonged use for more than 6 months, tachycardia, profuse sweating, chronic excessive intake of high doses of vitamin B6 can cause sensitivity disorders, photosensitivity when using high daily doses of the drug. Reporting adverse reactions If you experience any adverse reactions, it is recommended that you consult your doctor. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the adverse drug reactions (actions) information database, including reports of drug failures. By reporting adverse reactions, you help to get more information about the safety of the drug. Storage conditionsStore at a temperature not exceeding 25 °C. Store in a place protected from light. Keep out of the reach of children. Shelf life 3 years. Terms of dispensing from pharmacies By prescription. UpakovkaPo 20 tablets in PVC-PVDC/Al or Al/Al blister. 1 or 5 blisters in a cardboard box with instructions for medical use. Buy Neuromultivit tablets p/o No. 10×2 Price for Neuromultivit tablets p/o No. 10×2
Neuromultivit pills p/o №10×2
$28.00
SKU: 47825
Category: Vitamins and dietary supplements of group B
INN | THIAMINE, PYRIDOXINE, CYANOCOBOLAMINE |
---|---|
The code | 47 825 |
Barcode | 4 607 013 581 203 |
Active substance | Thiamine, pyridoxine hydrochloride, cyanocobalamin |
Manufacturer | G.L.Pharma GmbH, Austria |
Importer | Closed Joint Stock Company "BAUSH HEALTH", 220073, Minsk, st. Olshevsky, 22, room 22 |
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