Neurobeks Neo capsules №10х10

Name Neurobeks Neo caps. The main active ingredient Pyridoxine + thiamine + cyanocobalamin Release form Capsules Pharmacological properties The combination of B, PP and C vitamins in the Neurobex® Neo preparation is used to influence a number of important processes and functions of the body, and mainly on inflammatory and degenerative diseases of the nerves and the motor apparatus, provides increased body needs with infectious diseases, after chemotherapy and radiotherapy. All active components of the drug are rapidly absorbed in the small intestine and distributed in the body. They are excreted mainly in the urine. Since all the vitamins of Neurobex Neo are water-soluble, their accumulation in the body does not occur. Indications for use Neurobex Neo is used in the treatment of neurological disorders caused by vitamin deficiency, which cannot be eliminated by dietary modification. Dosage and administration The drug is taken 1 capsule 1 time per day during or after meals, without chewing, drinking plenty of liquid. The duration of admission is determined by the doctor. If symptoms persist for 4 weeks during treatment, you should consult a doctor. If you forget to take Neurobeks® Neo, take the capsule as soon as possible before the next dose is due. If it is time for your next dose of medication, do not take the missed dose. You can not double the dosage of the drug to compensate for the missed! Further, the drug is used according to the recommended dosing regimen. Application during pregnancy and lactation During pregnancy and lactation, the recommended daily dose for vitamin B1 is 1.4-1.6 mg and vitamin B6 is 2.4-2.6 mg. During pregnancy, these doses should only be exceeded after a careful benefit/risk assessment, as the safety of using vitamins B1 and B6 above the recommended daily dose has not yet been proven. Vitamin B1, B6 and B12 pass into breast milk. High doses of vitamin B6 may inhibit milk production. The use of this drug during pregnancy and lactation is possible only after a thorough assessment of the risk-benefit ratio. Influence on the ability to drive vehicles and work with machinery The drug does not affect the ability to drive a car and use machinery. Precautions With extreme caution should be used in patients with severe and acute forms of decompensated heart failure and angina pectoris. The drug is not recommended to be prescribed together with other drugs that contain vitamins, since an overdose of the latter in the body is possible. In patients with a tendency to hyperoxaluria, due to a possible increase in oxalate excretion, it is not recommended to take ascorbic acid in a dose of more than 1 g. Increased consumption of ascorbic acid over a long period can lead to an increase in renal clearance of ascorbic acid, followed by the development of a deficiency with a decrease in intake or quick cancellation. When conducting tests (determination of glucose, creatinine, uric acid in urine), it is necessary to take into account the possibility of the influence of ascorbic acid on obtaining distorted test results. The use of high doses of ascorbic acid can lead to false negative results in the determination of occult blood in the feces. It is not recommended to use the drug Neurobex Neo in children (it is recommended to use Neurobex tablets). Interaction with other drugs Ethyl alcohol dramatically reduces the absorption of thiamine. Thiamine is inactivated by 5-fluorouracil as a result of competitive inhibition of thiamine phosphorylation by the latter. With long-term treatment with furosemide, an increase in renal excretion of thiamine is possible. Vitamin B6 affects the metabolism of certain drugs. High doses of vitamin B6 reduce the antiparkinsonian effect of levodopa. This vitamin enhances the peripheral decarboxylation of levodopa and thus reduces its effectiveness in the treatment of Parkinson’s disease. It is an antagonist of isoniazid and thiosemicarbazones, correcting sideroblastic anemia caused by these anti-tuberculosis drugs. Prolonged use of penicillamine can lead to the development of vitamin B6 deficiency. Hydralazine and cycloserine are also its antagonists, and the simultaneous use of the vitamin with them reduces the adverse neurological reactions caused by these drugs. The amount of vitamin B6 decreases when taken simultaneously with oral contraceptives. Colchicine, ethyl alcohol and neomycin inhibit the absorption of vitamin B12. Oral antidiabetic agents of the biguanidine type, p-aminosalicylic acid, as well as chloramphenicol and vitamin C interfere with the absorption of the vitamin. Vitamin C increases the half-life of paracetamol, increases iron absorption, and increases renal excretion of amphetamine. The concentration of ascorbate in plasma decreases with smoking and taking oral contraceptives. In renal failure, oral vitamin C increases the absorption of aluminum, which can reach toxic levels. The simultaneous use of aluminum hydroxide and ascorbic acid may cause an increase in the absorption of aluminum in patients with normal renal function. Co-administration of ascorbic acid with amygdalin (alternative medicine) may lead to cyanide toxicity. Ascorbic acid can be used in conjunction with deferoxamine to increase iron excretion. However, in the early stages of treatment, when there is excess iron in the tissues, there is some evidence that ascorbic acid may increase iron toxicity, especially in the heart. Thus, ascorbic acid should not be administered within the first month after starting treatment with deferoxamine. Contraindications Hypersensitivity to the active substances or to any of the excipients in the composition of the drug. Acute thromboembolism. Erythrosis and erythremia. Hyperoxaluria. Deficiency of glucose-6-phosphate dehydrogenase. Malignant tumors. Composition Active substances in one capsule, mg: Cyanocobalamin 0.005 Nicotinamide 100 Calcium pantothenate 25 Folic acid 0.5 Ascorbic acid 175 (E110), titanium dioxide (E171), brilliant black (E151)) Overdose A single dose of vitamin B6 at a dose of less than 500 mg is safe. An overdose can lead to a decrease in the concentration of folates in the blood serum. With prolonged use, at a dose of 200 mg per day, sensory neuropathy is possible. Acute overdose of nicotinamide is not accompanied by serious side effects, but transient liver dysfunction may occur. Large doses of vitamin C can cause diarrhea and oxalate kidney stones. In case of an overdose, the symptoms of side effects of the drug increase. Perhaps the appearance of nervous excitement, tachycardia, pain in the heart. Treatment includes gastric lavage, the introduction of activated charcoal, the use of symptomatic agents. Side effects Neurobeks Neo is generally well tolerated. In rare cases, increased sweating, tachycardia, itching, urticaria are possible; in rare cases, allergic reactions, rashes, suffocation and the development of anaphylactic shock may occur. Significant doses of vitamins that are part of the drug can change the color of urine and change some laboratory parameters in the analysis of urine. It was reported about the development of photosensitivity when using high daily doses of B vitamins. From the digestive system: nausea, vomiting, discomfort in the stomach. High doses of ascorbic acid can cause diarrhea, hyperoxalaturia. Ascorbic acid can cause the development of hemolytic anemia in some patients with glucose-6-phosphate dehydrogenase deficiency. If side effects occur, tell your doctor about it. This applies to all possible side effects, including those not listed in this package insert. Storage conditionsAt a temperature of 15-25°C in a place protected from light and moisture. Keep out of the reach of children. The drug should not be used after the expiration date indicated on the package. Shelf life – 3 years from the date of issue. Buy Neurobex Neo capsules No. 10×10 Price for Neurobex Neo capsules No. 10×10 Instructions for use for Neurobex Neo capsules No. 10×10