Mildronate capsules 500mg №10×6

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Mildronate caps 500mg in a blister pack No.10×6
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Hard gelatin capsules, size No1, white; the contents of the capsules – white crystalline powder with a slight odor; the powder is hygroscopic. The main active ingredient Meldonium Release formHard gelatin capsules, size No1, white; the contents of the capsules – white crystalline powder with a slight odor; the powder is hygroscopic. 1 caps. meldonium dihydrate 250 mg Excipients: potato starch – 13.6 mg, colloidal silicon dioxide – 5.4 mg, calcium stearate – 2.7 mg. The composition of the capsule shell (body and cap): titanium dioxide (E171) – 2%, gelatin – up to 100%. 10 pieces. – cellular contour packings (4) – packs of cardboard. Hard gelatin capsules, size No00, white; the contents of the capsules – white crystalline powder with a slight odor; the powder is hygroscopic. 1 caps. meldonium dihydrate 500 mg Excipients: potato starch – 27.2 mg, colloidal silicon dioxide – 10.8 mg, calcium stearate – 5.4 mg. The composition of the capsule shell (body and cap): titanium dioxide (E171) – 2%, gelatin – 98%. 10 pieces. – cellular contour packings (2) – packs of cardboard. 10 pieces. – cellular contour packings (6) – packs of cardboard. Dosage 500 mg in blister pack No. 10×6 Special instructions Patients with chronic diseases of the liver and kidneys should be careful with prolonged use of the drug. If you need a long-term (more than a month) use of the drug, you should consult with a specialist. Use in pediatrics There are insufficient data on the use of the drug Mildronate® in children and adolescents under the age of 18 years. Influence on the ability to drive vehicles and control mechanisms There is no data on the adverse effects of the drug Mildronate® on the ability to drive vehicles and perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Pharmacological action Meldonium dihydrate is a synthetic analogue of gamma-butyrobetaine, a substance found in every cell of the human body. The mechanism of action determines the variety of pharmacological effects of the drug: increased efficiency, reduced symptoms of mental and physical overstrain, activation of tissue and humoral immunity, cardioprotective effect. It inhibits gamma-butyrobetainehydrooxinase, reduces the synthesis of carnitine and the transport of long-chain fatty acids through cell membranes, prevents the accumulation in cells of activated forms of unoxidized fatty acids – derivatives of acylcarnitine and acylcoenzyme A. Under conditions of ischemia, meldonium restores the balance between the processes of oxygen delivery and its consumption in cells, prevents violation of ATP transport; at the same time, it activates glycolysis, which proceeds without additional oxygen consumption. As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is intensively synthesized. It has a cardioprotective effect, normalizes myocardial metabolism. In acute ischemic myocardial damage, meldonium slows down the formation of a necrotic zone and shortens the rehabilitation period. In heart failure, the drug increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks. In acute and chronic ischemic disorders of cerebral circulation, it improves blood circulation in the focus of ischemia, promotes the redistribution of blood in favor of the ischemic area. Effective in vascular and dystrophic pathology of the fundus. It has a tonic effect on the central nervous system, eliminates functional disorders of the somatic and autonomic nervous system in patients with chronic alcoholism with withdrawal syndrome. Pharmacokinetics Absorption After oral administration, meldonium dihydrate is rapidly absorbed from the gastrointestinal tract. Bioavailability is 78%. Cmax in plasma is reached 1-2 hours after ingestion. Metabolism and excretion Metabolized mainly in the liver with the formation of two main metabolites, which are excreted by the kidneys. T1 / 2 when taken orally is 3-6 hours and depends on the dose. Indications for useCapsules 500 mg – as part of complex therapy for coronary artery disease (angina pectoris, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy; – as part of the complex therapy of subacute and chronic disorders of cerebral circulation (stroke and cerebrovascular insufficiency); – reduced performance; – mental and physical overstrain (including athletes); – withdrawal syndrome in chronic alcoholism (in combination with specific alcoholism therapy). Capsules 250 mg – reduced performance; – Mental and physical stress. Method of application and doses In connection with the possibility of developing an exciting effect, the drug is recommended to be used in the first half of the day and no later than 17.00 (when taken several times a day). With coronary artery disease (angina pectoris, myocardial infarction), chronic heart failure as part of complex therapy, the drug is administered orally at a dose of 0.5-1 g / day, the frequency of use is 1-2 times / day. The course of treatment is 4-6 weeks. With dyshormonal cardiomyopathy, Mildronate® as part of complex therapy is prescribed orally at 500 mg / day. The course of treatment is 12 days. In subacute disorders of cerebral circulation (stroke and cerebrovascular insufficiency), after the end of the course of injection therapy with Mildronate®, they continue to be taken as part of complex therapy by mouth at 0.5-1 g / day, using the entire dose once or dividing it into 2 doses. The course of treatment is 4-6 weeks. In chronic disorders of cerebral circulation, the drug is taken as part of complex therapy orally at 0.5 g / day. The general course of therapy is 4-6 weeks. Repeated courses are possible after consultation with a doctor (usually 2-3 times a year). With reduced performance, mental and physical overstrain (including athletes), 500 mg is administered orally 2 times / day. The course of treatment is 10-14 days. If necessary, therapy is repeated after 2-3 weeks. Athletes are recommended to use 0.5-1 g 2 times / day before training. Duration of the course in the preparatory period – 14-21 days, during the competition – 10-14 days. With withdrawal symptoms in chronic alcoholism (in combination with specific therapy for alcoholism), the drug is administered orally at 500 mg 4 times / day. The course of treatment is 7-10 days. Use during pregnancy and lactation The safety of the drug during pregnancy has not been established. In order to avoid possible adverse effects on the fetus, Mildronate® should not be prescribed during pregnancy. The excretion of meldonium dihydrate in breast milk and its effect on the health of the newborn have not been studied. If necessary, the use of the drug Mildronate® during lactation, breastfeeding should be discontinued. Precautions The drug should be used with caution in diseases of the liver and / or kidneys. Contraindicated for use in children and adolescents under 18 years of age (efficacy and safety not established). Interaction with other drugsMildronate® enhances the effect of coronary dilating agents, some antihypertensive drugs, cardiac glycosides. Mildronate® can be combined with prolonged forms of nitrates, other antianginal drugs, anticoagulants and antiplatelet agents, antiarrhythmics, diuretics and bronchodilators. In view of the possible development of tachycardia and arterial hypotension, caution should be exercised when combined with nitroglycerin (for sublingual use) and antihypertensive agents (especially alpha-blockers and short-acting forms of nifedipine). Simultaneous use of the drug together with other meldonium preparations is not allowed, since the risk of adverse reactions may increase. Contraindications – increased intracranial pressure (including in violation of venous outflow, intracranial tumors); – age up to 18 years (efficacy and safety have not been established); – pregnancy; – lactation period (breastfeeding); – hypersensitivity to the active substance and other components of the drug. Composition 1 caps. meldonium dihydrate 500 mg Excipients: potato starch – 27.2 mg, colloidal silicon dioxide – 10.8 mg, calcium stearate – 5.4 mg. The composition of the capsule shell (body and cap): titanium dioxide (E171) – 2%, gelatin – 98%. 10 pieces. – cellular contour packings (2) – packs of cardboard. 10 pieces. – cellular contour packings (6) – packs of cardboard. Overdose No cases of drug overdose have been reported. The drug has low toxicity and does not cause severe adverse reactions. Symptoms: decrease in blood pressure, accompanied by headache, tachycardia, dizziness and general weakness. Treatment: symptomatic therapy. In severe overdose, it is necessary to monitor the functions of the liver and kidneys. Side effects Meldonium is generally well tolerated. However, in susceptible patients, as well as in cases where the recommended dose is exceeded, adverse reactions may occur. Adverse drug reactions are grouped into systemic organ classes according to the following frequency gradation: very often (?1/10), often (?1/100 and <1/10), infrequently (?1/1000 and <1/100) , rare (≥1/10,000 and <1/1000), very rare (<1/10,000), the frequency is unknown (it is impossible to estimate the frequency from the available data). From the side of the hematopoietic system: the frequency is unknown - eosinophilia. From the immune system: often - allergic reactions (reddening of the skin, rashes, itching, swelling). From the nervous system: often - headaches; frequency unknown - excitation. From the side of the cardiovascular system: very rarely - tachycardia, lowering blood pressure. From the digestive system: often - dyspeptic phenomena. Other: frequency unknown - general weakness. If any of the side effects indicated in the instructions are aggravated, or any other side effects not indicated in the instructions are noted, the patient should inform the doctor about this. Storage conditions The drug should be stored out of the reach of children, in a dry place at a temperature not exceeding 25 ° C. Buy Mildronate capsules 500mg No. 10x6 Price for Mildronate capsules 500mg No. 10x6