Name:
Levomycetin to-whether hl 2,5mgml fl 5ml in pack No. 1 BMP
Description:
Transparent colorless or slightly colored solution. The main active ingredient Chloramphenicol Release form Eye drops Dosage 2.5 mg / ml Pharmacological action A bacteriostatic broad-spectrum antibiotic that disrupts the process of protein synthesis in a microbial cell. Effective against strains of bacteria resistant to penicillin, tetracyclines, sulfonamides. Active against: Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, some species of Enterobacter and Neisseria, Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus hemolyticus), Moraxella lacunata, rickettsia and mycoplasmas. Ineffective against Pseudomonas aeruginosa, Serratia marcescens. Indications for use Bacterial eye infections caused by sensitive microflora: conjunctivitis, keratitis, blepharitis, blepharoconjunctivitis, keratoconjunctivitis. Dosage and administration The drug is applied topically in the form of instillations into the conjunctival sac, 1-2 drops 3-4 times a day. Treatment should last no more than 5 days, even if the condition improves. Elderly patients (over 65 years of age). Dose adjustment is not required. Recommendations for the use of vials with dropper caps: before using the drug, remove the aluminum cap from the vial, remove the rubber stopper and close the vial with a dropper cap, previously released from the packaging. Then remove the cap from the dropper cap, turn the vial over, drip the required number of drops of the drug. After use, return the bottle to a vertical position and put the cap on the dropper cap. Use during pregnancy and lactation In animal studies, it has been established that chloramphenicol has an embryotoxic and teratogenic effect. Chloramphenicol passes through the placenta. The safety of the use of eye drops during pregnancy has not been established, so the use is contraindicated. Chloramphenicol is excreted in breast milk. During the use of eye drops, systemic absorption of the drug is not excluded. Therefore, due to the risk of serious adverse reactions in children, use during breastfeeding is contraindicated. Influence on the ability to drive vehicles and potentially dangerous mechanisms Eye drops may cause temporary blurred vision. Patients should not drive or operate machinery until vision is restored. Precautions Long-term use of Levomycetin eye drops should be avoided, as there is a possibility of hypersensitivity and the emergence of resistant microorganisms. The composition of the drug includes boric acid, which can cause toxic reactions. Chloramphenicol is subject to systemic absorption from the eyes, and cases of toxicity have been reported with chronic exposure. There is information on bone marrow hypoplasia, including aplastic anemia and death, after topical application of chloramphenicol. Although the danger is rare, the ratio between the expected risk and benefit should be assessed before using the drug. When using the drug on a long-term or intermittent basis, it is advisable to perform routine blood tests before starting therapy and at appropriate intervals thereafter to detect any changes in hematopoiesis. Precautions are prescribed to patients who have previously received treatment with cytotoxic drugs or radiation therapy. Patients should see a doctor if any of the following conditions occur: blurred vision; severe pain in the eyes; photophobia; the appearance of rashes on the face and head; the eye looks cloudy; the pupil looks unusual; there was a sensation of a foreign body in the eye. Patients must inform the doctor about: – previous conjunctivitis; – glaucoma; – dry eye syndrome; – eye surgery or laser therapy within the last 6 months; – eye injury; – current use of other eye drops or eye ointment; – wearing contact lenses. Contact lenses should not be worn during the course of treatment. Soft contact lenses should not be worn for 24 hours after treatment is completed. Interaction with other drugs Simultaneous use of chloramphenicol with drugs that inhibit hematopoiesis (sulfonamides, cytostatics) that affect metabolism in the liver; with radiation therapy increases the risk of side effects. Therefore, such combinations should be avoided. With simultaneous use with erythromycin, clindamycin, lincomycin, a mutual weakening of the action is noted due to the fact that chloramphenicol can prevent their binding to the 50S subunit of bacterial ribosomes. Levomycetin reduces the antibacterial effect of penicillins and cephalosporins. With the combined use of levomycetin with oral hypoglycemic drugs, there is an increase in their action due to the suppression of metabolism in the liver and an increase in their concentration in plasma. Chloramphenicol inhibits the cytochrome P450 enzyme system, therefore, with simultaneous use with phenobarbital, phenytoin, indirect anticoagulants, there is a weakening of the metabolism of these drugs, a slowdown in excretion and an increase in their plasma concentration. Storage conditions Contraindications Hypersensitivity to levomycetin (as well as to thiamphenicol, azidamphenicol), suppression of bone marrow hematopoiesis, acute intermittent porphyria, glucose-6-phosphate dehydrogenase deficiency, liver and / or kidney failure, myelosuppression against the background of the use of levomycetin in history, myelosuppression in a personal or family history , skin diseases (psoriasis, eczema, fungal infections), pregnancy, lactation (rejection of breastfeeding is required), children under 2 years of age. Caution should be used in childhood, in patients who have previously received treatment with cytotoxic drugs or radiation therapy. Composition Per vial (5 ml): active substance: chloramphenicol – 12.5 mg; excipients: boric acid, water for injection. Overdose It is unlikely that accidental ingestion of eye drops will cause systemic toxic effects due to the low content of chloramphenicol. If pain, swelling, lacrimation or photophobia develop, flush the affected eye with water for at least 15 minutes. If the above symptoms persist, you should consult a doctor. Side effect On the part of the organ of vision: short-term irritation, burning, itching, conjunctival hyperemia. From the immune system: hypersensitivity reactions, angioedema, anaphylaxis, urticaria, fever, dermatitis. On the part of the blood and lymphatic system: there are separate reports on the development of bone marrow hypoplasia and aplastic anemia after the use of ophthalmic forms of chloramphenicol. In case of adverse reactions, including those not listed in this leaflet, you should consult a doctor. Storage conditions In a place protected from light at a temperature not exceeding 25 ° C. Store the opened vial in a place protected from light at a temperature of 15 ° C to 25 ° C for 4 weeks. Keep out of the reach of children. Buy Levomycetin solution (q-li hl) 2.5mg/ml in vial 5ml in set with cr-cap. 5ml in set with cr-cap. in pack No. 1
INN | CHLORAMPHENICOL |
---|---|
The code | 71 006 |
Barcode | 4 810 133 006 031 |
Dosage | 2.5mg/ml 5ml |
Active substance | Chloramphenicol |
Manufacturer | Belmedpreparaty RUE, Belarus |
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