Indapamide Pharmland tablets p/o 2.5mg №10×3

NameIndapamide Pharmland tablets, p/o 2.5 mg in a cell.pack No. 10×3 starch glycolate, magnesium stearate, talc, hydroxypropyl methylcellulose 15 cps, titanium dioxide (E171), propylene glycol, orange yellow varnish (E 110). Belongs to the group of diuretics – sulfonamides. The main active substance Indapamide Form of release: coated tablets Dosage 2.5 mg Indications for use Indapamide Pharmland is used in the following cases – the treatment of arterial hypertension as monotherapy or in combination with other antihypertensive drugs. Dosage and administration Tablets are taken orally. With arterial hypertension, 2.5 mg (1 tablet) is prescribed 1 time per day in the morning. With insufficient effectiveness after 4-8 weeks, it is advisable to add antihypertensive drugs with a different mechanism of action to therapy (increasing the dose is not advisable: a slight increase in the effect with an increase in side effects). The duration of admission is determined by the doctor. Elderly patients. With normal or slightly reduced kidney function, dose adjustment is not required. Children. Contraindicated. Use during pregnancy and lactation is contraindicated. If necessary, breastfeeding women should stop breastfeeding for the period of treatment. PrecautionsLiver failure. Patients with hepatic insufficiency may develop hepatic encephalopathy. If symptoms of hepatic encephalopathy appear, indapamide should be discontinued. Water and electrolyte balance Plasma sodium level. Taking diuretics can lead to a decrease in sodium with serious consequences. It is recommended to control the level of sodium in the blood before starting treatment and systematic monitoring during the treatment period. Plasma potassium level. A decrease in the content of potassium in the blood is the main risk of taking thiazide and other diuretics based on it. Risk groups for the development of this pathology are: elderly people, patients with malnutrition and / or taking several drugs at the same time, with edema and ascites against the background of cirrhosis of the liver, with diseases of the coronary vessels and heart, with an extended QT interval. In this situation, hypokalemia increases the toxicity of drugs with digitalis and the risk of arrhythmias. Bradycardia against the background of hypokalemia contributes to the development of severe arrhythmias, in particular, potentially fatal atrial flutter-fibrillation. It is recommended to control the level of potassium in the plasma in these groups before starting treatment and systematic monitoring during the treatment period. If hypokalemia is detected, potassium deficiency is compensated. Plasma calcium level. Thiazide and thiazide-like diuretics may decrease urinary calcium excretion, causing a modest increase in blood calcium levels. Severe hypercalcemia may be a sign of unrecognized hyperparathyroidism. In this case, it is necessary to interrupt the treatment and conduct an examination of the function of the parathyroid glands of the patient. Blood sugar level. In patients with diabetes mellitus, especially those with concomitant hypokalemia, it is necessary to monitor blood glucose levels. Uric acid. Patients with hyperuricemia tend to have an increased frequency of gout attacks. With an increase in the level of uric acid, dose adjustment is necessary. Kidney dysfunction. Thiazides and thiazide-like diuretic drugs are fully effective only in the case of normal or mild renal function (creatinine level below 25 mg/l, i.e. 220 mmol/l). Hypovolemia associated with fluid loss, which may occur at the beginning of treatment, leads to a decrease in glomerular filtration, which in turn causes an increase in the concentration of urea and creatinine in the blood. This transient functional renal failure resolves without consequences in patients with normal renal function, while at the same time it can aggravate already existing renal failure. Athletes. The medicinal product may cause false positive results in anti-doping tests in athletes. Interaction with other drugs When prescribing Indapamide Pharmland, be sure to inform your doctor about taking any of the following medicines. Medicines that should not be taken concomitantly with indalamide: Lithium preparations. Overdose symptoms are possible. Drugs affecting the heart rhythm (antiarrhythmic drugs from group Ia and class IIIa: quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide); certain antipsychotic drugs (phenothiazine derivatives: chlorpromazine, cyamemazine, levomepromazine, thioridazine, trifluoroperazine; benzamides: amisulpiride, sulpiride, sultopride, tiapride; butyrophenones: droperidol, haloperidol); others: bepridil, cisapride, diphemanil, intravenous erythromycin, halofantrine, pentamidine, mizolastine, sparfloxacin, moxifloxacin, intravenous vincamine. Possible prolongation of the QT interval, a decrease in heart rate and the appearance of arrhythmias, especially against the background of a low level of potassium in the blood. Medicinal products to be used with caution: Non-steroidal anti-inflammatory drugs (when taken by mouth), high doses of salicylates (> 3 g/day). It is possible to reduce the hypotensive effect of indapamide, increase the risk of developing acute renal failure in dehydrated patients. Monitoring of kidney function is recommended. Other drugs that cause a decrease in the level of potassium in the blood: amphotericin B (when administered intravenously), glucocorticoids and mineralocorticoids (when taken by mouth), tetracosactide, osmotic laxative drugs. risk of developing hypokalemia. It is necessary to monitor the concentration of potassium in the blood. Baclofen. Strengthening the hypotensive effect of indapamide. Monitoring of kidney function is recommended. digitalis glycosides. Hypokalemia is a factor predisposing to the development of symptoms of digitalis glycoside toxicity. Recommended monitoring of potassium levels, ECG. Angiotensin-converting enzyme inhibitors (ACE inhibitors). The risk of a sudden drop in blood pressure and the development of acute renal failure if the use of an ACE inhibitor is started with a deficiency of sodium in the blood. Monitoring of kidney function is recommended. Potassium-sparing diuretics (amiloride, spironolactone, triamterene). When used together, the risk of hypokalemia is not excluded; hyperkalemia may develop in patients with renal insufficiency or diabetes mellitus. It is recommended to control the level of potassium in the blood. Metformin. Acidosis may develop. It is recommended to control the level of creatinine in the blood. Iodine-containing radiopaque agents. Against the background of dehydration caused by diuretics, the risk of developing acute renal failure increases. Combinations, the expediency of which should be carefully evaluated Tricyclic antidepressants, antipsychotics. Strengthening of hypotensive action and risk of development of orthostatic hypotension. Salts of calcium. Decreased excretion of calcium by the kidneys and the risk of increasing the level of calcium in the blood. It is recommended to control the level of calcium in the blood. Cyclosporine, tacrolimus. The risk of increasing the level of creatinine in the blood. It is recommended to control the level of creatinine in the blood. Corticosteroids, tetracosactyl (by mouth). Decreased hypotensive effect of indapamide. Contraindications hypersensitivity to indapamide, sulfonamide derivatives or other components of this drug; severe renal failure (creatinine clearance less than 30 ml / min); severe liver failure (including with encephalopathy); low blood potassium levels; lactase deficiency, intolerance lactose, glucose-galactose malabsorption; pregnancy, lactation; age up to 18 years; simultaneous use of drugs that prolong the QT interval (lactose for direct compression), sodium starch glycolate, magnesium stearate, talc, hydroxypropyl methylcellulose 15 cps, titanium dioxide (E171), propylene glycol, orange yellow varnish (E 110). Belongs to the group of diuretics – sulfonamides. Overdose If the number of tablets per day that you have taken exceeds the amount recommended by your doctor, or your child has swallowed the tablets, immediately consult a doctor or call an ambulance! Stop taking the medicine immediately! The clinical picture of acute overdose is characterized by symptoms of water and electrolyte imbalance, which are manifested by nausea, vomiting, decreased blood pressure, spasms, dizziness, drowsiness, depression, changes in the amount of urine, up to its absence, dehydration. As a first aid, induce vomiting, rinse the stomach. Side effects Like all medicines, Indapamide Pharmland can cause side effects with varying frequency, regardless of whether it has been used before. Often (1 in 10-100 cases): maculopapular rash, low blood potassium. Uncommon (1 in 100-1,000 cases): vomiting, purpura, prolongation of the QT interval on ECG Rare (1 in 1,000-10,000 cases): dizziness, fatigue, headache, paresthesia, nausea, constipation, dry mouth . Very rarely (less than 1 in 10,000 cases): a decrease in the number of blood cells, anemia, heart rhythm disorders, arterial hypotension, pancreatitis, renal failure, abnormal liver function, vasomotor edema and / or urticaria, toxic epidermal necrolysis, Stevens-Johnson syndrome, high levels of calcium in the blood. Frequency unknown: hepatic encephalopathy secondary to liver failure, exacerbation of systemic lupus erythematosus, photosensitivity, low blood sodium, dehydration, orthostatic hypotension, metabolic alkalosis, high uric acid and high blood glucose. Storage conditionsKeep in a place protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children. Buy Indapamide Pharmland tablets p/o 2.5 mg No. 10×3