Name:
Heparin gel 600EDg 30g
Description:
Uniform colorless or with a yellowish tint, transparent or almost transparent gel with an aromatic odor. Air bubbles are allowed. The main active ingredient Heparin sodium Product form gel Dosage 30 g Pharmacological action Pharmacodynamics Heparin gel has a pronounced anti-exudative, anti-edematous, anti-granulomatous, anti-inflammatory and anticoagulant action. Due to its strong anionic charge, heparin forms a complex with cationic protein bodies. This is especially true for antithrombin III (AT III) and α2-globulin, and leads to a pronounced increase in the rate of their inhibitory reactions. Thus, heparin has the function of a catalyst, inhibiting serine proteases depending on the affinity of AT III for individual enzymes in the coagulation cascade. Thus, not only thrombin (IIa) is inactivated, but also activated factors XIIa, XIa, IXa, Xa, and kallikrein. This inactivation is dose dependent. In addition, heparin also promotes lipolysis by activating a clearing factor and catalyzing the release of lipoprotein lipase from endothelial cells, resulting in the dissolution of high molecular weight chylomicrons in plasma. Heparin is involved in anaphylactic reactions. In mast cells, salt-like bonds exist between histamine, heparin and cofactor, which are cleaved when heparin and histamine are released during mast cell degranulation under the influence of a histamine liberator. In addition, heparin as a macroanion inhibits or activates a number of enzyme systems, such as hyaluronidase, histaminase and ribonuclease. Pharmacokinetics Pharmacokinetic studies in rats have shown that heparin is found in plasma up to 24 hours after administration; the maximum concentration is reached after eight hours. Heparin is excreted mainly through the kidneys. The use of Heparin gel on the skin does not cause changes in coagulation parameters. Heparin, when administered parenterally, rapidly accumulates in the vascular endothelium and in the reticuloendothelial system or is excreted from the blood with a half-life of 90-120 minutes. Initially, the rapid elimination of heparin is probably based on its rapid binding by endothelial cells and absorption by the reticuloendothelial system. It is also excreted according to the plasma concentration profile. Heparin is excreted partially unchanged or by filtration and tubular secretion as a low molecular weight cleavage product. Uroheparin excreted in the urine is not a single substance, it consists of a mixture of acting unchanged heparin and low molecular weight cleavage products, potentially still having reduced coagulation physiological activity. Heparin does not pass through the placental barrier and does not pass into breast milk. When administered orally, heparin is poorly absorbed. The penetration of heparin into healthy skin has been described to be dose dependent at doses equal to or greater than 300 IU/g. After topical application at doses of 150,000 IU / 100 g, systemic therapeutically effective concentrations will not be achieved. After the use of very large doses (more than 180,000 IU / 100 g), systemic concentrations can be reached, leading to an increased risk of bleeding. Indications for use For symptomatic treatment and reduction of edema and bruising after blunt trauma (for example, after a bruise); For symptomatic treatment of diseases of superficial veins (varicose veins, phlebitis, periphlebitis, thrombophlebitis), varicose ulcers, varicophlebitis, condition after removal of the great saphenous vein in the as part of complex therapy. Dosage and administration Use the drug 1-3 times a day. Apply 3-10 cm of gel to the affected area of the skin and rub gently. The duration of treatment is determined individually, taking into account the severity of the course of the disease. Due to the limited experience with the drug in children and due to the fact that there is an insufficient amount of research data, this drug should not be used in the treatment of children. Use during pregnancy and lactation There are no data on the use of the drug during pregnancy and lactation. Precautions If there are signs of bleeding, the possibility of using the drug should be carefully considered. Heparin gel should not be used for bleeding, applied to open wound surfaces, weeping eczema or mucous membranes, as well as to infected areas in the presence of purulent processes. The penetration of heparin into healthy skin is described in the case of topical application; therefore, if thromboembolic complications are suspected, a platelet count should be checked to differentiate between type II heparin-induced thrombocytopenia. Thus, regular checks of platelet counts in patients with a history of thromboembolic complications are necessary with each use of heparin (before starting heparin, on the first day after the start of use, and then regularly every 3-4 days during treatment until its end). Heparin gel contains methyl parahydroxybenzoate and propyl parahydroxybenzoate as excipients, so it should not be used in patients allergic to parabens. Dimethyl sulfoxide and propylene glycol, which are part of the drug, can irritate the skin. Interaction with other drugs The use of heparin may help prolong prothrombotic time in patients taking oral anticoagulants. Do not use the drug together with drugs for topical use, for example, drugs containing tetracycline, hydrocortisone, salicylic acid, anticoagulants. Contraindications Heparin gel should not be used: in case of known hypersensitivity to heparin or any of the other components in the case of heparin-induced thrombocytopenia type II (HIT type II, mediated by immunity) in history. ME, 1000 IU of sodium heparin. Excipients: carbomer, propylene glycol, ethyl alcohol 96%, dimethyl sulfoxide, methyl parahydroxybenzoate, propyl parahydroxybenzoate, diethanolamine, lavender oil, purified water. Overdose So far, cases of overdose have not been described. In the event that this happens, the effect of heparin can be neutralized with protamine sulfate. Side effects Allergic reactions to heparin after applying the drug to the skin are very rare. However, in some cases, hypersensitivity reactions may occur, such as redness of the skin and itching, which quickly disappear after discontinuation of the drug. The incidence of heparin-induced antibody-mediated thrombocytopenia type II (platelet count <100,000/mcL or abrupt decrease in platelet count to <50% of baseline with arterial and venous thrombosis and embolism) has not been studied with topical heparin. However, since penetration into healthy skin has been described, this risk cannot be ruled out. Therefore, extreme caution is advised (see PRECAUTIONS). With parenteral heparin in patients without pre-existing hypersensitivity to heparin, a decrease in the number of platelets, as a rule, can occur 6-14 days after the start of treatment. In patients with hypersensitivity to heparin, thrombocytopenia may develop within a few hours. If you experience any side effect, whether it is described in this section or not, you should immediately contact your doctor. Storage conditionsStore at a temperature not exceeding 25°C. Keep out of the reach of children. Buy Heparin gel 600me/g 30g №1 Price for Heparin gel 600me/g 30g №1Instruction for use for Heparin gel 600me/g 30g №1
Heparin gel 600m/g 30g №1
$20.00
SKU: 97100
Category: Treatment and prevention of hemorrhoids and varicose veins
INN | HEPARIN |
---|---|
The code | 97 100 |
Barcode | 4 810 183 003 899 |
Dosage | 600IU/g |
Active substance | Heparin |
Manufacturer | Pharmtekhnologiya LLC, Belarus |
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