Helmintox tablets p/o 250mg №3×1

Name:
Helminthox tabl p/pl. about. 250mg in bl. in pack. No. 3×1 Main active ingredient Pyrantel Release form Tablets Composition Per 1 tablet 125 mg 250 mg Active ingredient: Pyrantel embonate 360.5 mg 721.0 mg in terms of pyrantel 125.0 mg 250.0 mg Excipients: Pregelatinized corn starch 19.95 mg 39 .9 mg Povidone 15.75 mg 31.5 mg Croscarmellose sodium 16.8 mg 33.6 mg Magnesium stearate 7.00 mg 14.0 mg Film coating composition: SepifilmTM 002 (hypromellose, microcrystalline cellulose, macrogol 8 stearate type I) 12.5 mg 25.0 mg SepispersTM AP3065 yellow (propylene glycol, titanium dioxide (E 171), sunset yellow (E 110), hypromellose, water) 8.3 mg 16.6 mg calculated as anhydrous substance 7 .5 mg 15.0 mg
Description:
Oblong yellow-orange film-coated tablets scored on one side. On a transverse section, the kernel is lemon-yellow in color. Dosage 250 mg Pharmacological properties Pharmacodynamics The anthelmintic drug causes a neuromuscular blockade of helminths sensitive to it and ensures their expulsion without excitation and stimulation of the migration of the affected worms. In the intestinal lumen, it is effective against mature and immature sensitive helminths of both sexes. Highly effective against infestations caused by pinworms (Enterobius vermicularis), roundworms (Ascaris lumbricoides), hookworms (Ankylostoma duodenale and Necator americanus). Pharmacokinetics Practically not absorbed from the gastrointestinal tract. After taking a single dose of 12.5 mg / kg, plasma concentration is 0.05-0.13 μg / ml for 1-3 hours. Metabolized partially in the liver to N-methyl-1.3-propanediamine. Excretion through the intestines – about 93% unchanged, 7% – by the kidneys unchanged or as a metabolite. Indications for use Ascariasis, enterobiasis (pinworm infection), hookworm. Contraindications Hypersensitivity to pyrantel and other components of the drug; myasthenia gravis; liver failure; breastfeeding period. Children’s age up to 6 years. Use during pregnancy and lactation With caution, the drug is prescribed during pregnancy, if the intended benefit to the mother outweighs the potential risk to the fetus. There is no data on the penetration of the drug into breast milk, therefore, if necessary, the appointment of the drug during lactation should stop breastfeeding. Influence on the ability to drive vehicles There is no evidence of a negative effect of the drug on the ability to drive vehicles and other mechanisms. Method of administration and doses For oral administration. The tablets are intended for adults and children over 6 years of age. Helmintox can be taken at any time of the day, without first taking laxatives, not necessarily on an empty stomach. Pinworms and roundworms In the treatment of enterobiasis and ascariasis, the drug in the recommended dose. The usual dosage is 12.5 mg / kg body weight once, that is: – children over 6 years old: 1 tablet 125 mg per 10 kg body weight once; – adults weighing less than 75 kg: 3 tablets of 250 mg once; – adults weighing more than 75 kg: 4 tablets of 250 mg once. To prevent re-infection, it is recommended to repeat the drug after 3 weeks. Hookworms: In endemic areas, in case of infection with Necator americanus or in case of severe infection with Ankylostoma duodenale, the dosage is 25 mg/kg/day (in one or two doses) for two to three days, i.e.: – children: 250 mg per 10 kg body weight daily – adults weighing less than 75 kg: 1.5 g per day – adults weighing more than 75 kg: 2 g per day. In case of infection with Ankylostoma duodenale outside the endemic zones (more easily), it is prescribed at a dose of 12.5 mg / kg at a time. Side effects From the gastrointestinal tract: nausea, vomiting, abdominal pain, diarrhea and loss of appetite are rarely noted (most often these symptoms are explained by the death of helminths); Allergic reactions – itching, urticaria, exanthema; A slight short-term increase in the activity of “liver” transaminases; Headache, dizziness, fatigue, drowsiness or insomnia, hearing loss, hallucinations, confusion, paresthesia, hyperthermia. If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions, tell your doctor. Overdose Even a severe overdose does not cause signs of serious intoxication. There is no specific antidote. It is recommended to wash the stomach and consult a doctor. Interaction with other drugs The simultaneous use of levamisole, piperazine is not recommended. Increases the concentration of theophylline in plasma. PrecautionsSpecial preparation and diet when prescribing Helmintox is not required. In case of existing liver diseases, it is necessary to warn the doctor. It should be remembered that before prescribing Helmintox, like any other anthelmintic drug, you should carefully clean the room, wash children’s toys, take a shower before and after sleep and change your underwear. It is advisable to iron bed linen on the days of treatment and several days after taking the drug with a hot iron. In order to avoid re-infection, it is necessary to strictly observe the rules of hygiene: wash hands, cut and clean nails, avoid scratching the perineal area, change bed and underwear daily. At the same time, treatment of all family members is recommended. Infection often does not show any symptoms. After completion of treatment, it is necessary to conduct a control study of feces for the presence of helminth eggs. Storage conditionsStore at a temperature not exceeding 25 °C. Keep out of the reach of children. Buy Helmintox tablets p/o 250mg No. 3×1 Price for Helmintox tablets p/o 250mg No. 3×1