Halixol tablets 30mg №10×2

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Halixol tablets 30 mg in bl. in pack. No. 10×2
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Tablets of white or almost white color, flat, round, with a bevel, with a line on one side and an engraving “E231” on the other, odorless or almost odorless. The main active ingredient Ambroxol Release form Tablets are white or almost white, flat, round, chamfered, with a risk on one side and engraved “E231” on the other, odorless or almost odorless. 1 tab. Active substance: ambroxol hydrochloride 30 mg; Excipients: lactose monohydrate – 84 mg, microcrystalline cellulose – 30 mg, sodium carboxymethyl starch (type A) – 10 mg, povidone K30 – 5 mg, magnesium stearate – 1 mg. 10 pieces. – blisters (2) – packs of cardboard. Dosage 30mg in bl. in pack. No. 10×2 Special instructions text Pharmacological action Expectorant (mucolytic) drug. Ambroxol is an active metabolite of bromhexine, belongs to the benzylamine group of mucolytic substances. Liquefies sputum by increasing the production and activity of hydrolytic enzymes that break down bonds between sputum mucopolysaccharides. Improves the rheological properties of sputum, reducing its viscosity and adhesive properties, by stimulating the serous cells of the glands of the bronchial mucosa and normalizing the ratio of the mucous and serous components of sputum. Increases mucociliary transport, increasing the motor activity of the ciliated epithelium. Does not cause excessive secretion, reduces spastic bronchial hyperreactivity. Promotes the production of surfactant. The effect develops 30 minutes after taking the drug. Pharmacokinetics Absorption After oral administration, it is almost completely absorbed from the gastrointestinal tract. Bioavailability after oral administration is approximately 60%. The time to reach Cmax in plasma is 2 hours. Distribution Plasma protein binding is about 80%. Penetrates through the placental barrier. Its concentration in the body of the fetus is 2-4 times higher than that of the mother. Found in breast milk and cerebrospinal fluid. Metabolism Exposed to active metabolism during the “first pass” through the liver. Excretion T1 / 2 is about 7 hours. About 90% of the dose taken is excreted in the urine in the form of a glucuronide conjugate of ambroxol or oxidized products of its metabolism. Pharmacokinetics in special clinical cases T1 / 2 increases with severe renal failure, does not change with impaired liver function. Indications for use Acute and chronic diseases of the respiratory system, accompanied by the formation of viscous sputum: bronchitis, bronchial asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis; inflammatory diseases of the ENT organs (sinusitis, otitis media), in which mucus thinning is necessary. Dosage and administration For adults and children over 12 years of age, the drug is prescribed in the first 2-3 days, 1 tab. 3 times / day, and in the following days – 1 tab. 2 times / day or 1/2 tab. 3 times / day. In severe cases of the disease, the dose is not reduced during the entire course of treatment. For children aged 5-12 years, the drug is prescribed 1/2 tab. 2-3 times / day. Children under the age of 5 years are not prescribed the drug Halixol in the form of tablets. The question of the need to take Halixol for more than 4-5 days, the doctor decides individually. Tablets should be taken orally after a meal and washed down with plenty of liquid. Abundant fluid intake helps to thin the mucus during treatment with Halixol. Use during pregnancy and lactation The drug is contraindicated for use in the first trimester of pregnancy. Ambroxol is excreted in breast milk, therefore, if it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be resolved. Precautions The drug should be used with caution in severe renal failure. Interaction with other drugs Antitussive drugs (including codeine) can make it difficult to excrete sputum diluted with ambroxol. Halixol® promotes the penetration of certain antibiotics into the bronchial secret (including amoxicillin, cefuroxime, erythromycin, doxycycline). Contraindications Ulcerative lesion of the gastrointestinal tract; I trimester of pregnancy; lactation period (breastfeeding); hypersensitivity to ambroxol or bromhexine; The drug should be used with caution in severe renal failure. Composition Active substance: ambroxol hydrochloride 30 mg; Excipients: lactose monohydrate – 84 mg, microcrystalline cellulose – 30 mg, sodium carboxymethyl starch (type A) – 10 mg, povidone K30 – 5 mg, magnesium stearate – 1 mg. Overdose Symptoms: nausea, vomiting, diarrhea, dyspepsia. Treatment: induce vomiting, then prescribe a drink (milk or tea), intake of fat-containing foods. Gastric lavage is recommended within 1-2 hours after taking the drug. The function of the cardiovascular system should be constantly monitored. Side effect From the side of the central nervous system: rarely – weakness, headache. From the digestive system: rarely – diarrhea, constipation, dry mouth, gastralgia, nausea, vomiting. From the respiratory system: rarely – dryness of the respiratory tract, rhinorrhea. Allergic reactions: rarely – exanthema, urticaria; extremely rarely – acute anaphylactic reactions, the causal relationship of which with the use of ambroxol has not been established. Other: dysuria. Halixol is generally well tolerated. Storage conditions The drug should be stored at a temperature not exceeding 30 ° C in a place protected from light, out of the reach of children. Buy Halixol tablets 30mg No. 10×2 Price for Halixol tablets 30mg No. 10×2