Diazolin dragee 0.05g 10×2

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Diazolin dragee 0.05g in a blister pack No. 10×2
Description:
Dragee white. Dragee should be the correct spherical shape. The surface of the dragee should be flat, smooth and uniform in color. The main active ingredient Mebhydrolin Release form Dragee Dosage 1 dragee contains mebhydrolin in terms of 100% dry matter 50 mg (0.05 g) or 100 mg (0.1 g) Special instructions Antihistamines for systemic use. АТС code R06A Х15 Pharmacological action Pharmacokinetics It is rapidly absorbed from the digestive tract and penetrates into all tissues of the body. Bioavailability ranges from 40-60%. Plasma protein binding more than 90%. The therapeutic effect develops after 15-30 minutes, the maximum effect is observed after 1-2 hours. The duration of the effect can be up to 2 days. The plasma half-life is about 4 hours. The drug practically does not penetrate the blood-brain barrier, is metabolized in the liver by methylation, induces liver enzymes, is excreted from the body by the kidneys, which must be taken into account in patients with impaired function of the cardiovascular system, liver, kidneys, as well as elderly patients. Indications for use Prevention and treatment of seasonal and allergic rhinitis, hay fever, urticaria, food and drug allergies, dermatosis accompanied by skin itching (eczema, neurodermatitis) Dosage and administration Dosage orally, during or immediately after meals, for adults and children over 7 years of age . Adults and children over 12 years of age are prescribed 100-200 mg 1-2 times a day. The highest single dose is 300 mg, the highest daily dose is 600 mg. Children aged 7 to 12 years – 50 mg 1 to 3 times a day. The duration of treatment is determined by the doctor depending on the clinical effect and tolerability of the drug. Use with caution in patients with hepatic and renal insufficiency, in elderly patients (dose adjustment and intervals between doses may be required). If you miss a dose, take the missed dose as soon as possible. If there are several hours left before the next dose, only the next dose should be taken. A double dose of the drug should not be taken. If necessary, you should consult your doctor. Use during pregnancy and lactation During pregnancy or lactation, the drug is contraindicated. PrecautionsDiazolin® is prescribed with caution in severe hepatic and / or renal insufficiency (dose adjustment and increase in intervals between doses are possible). During treatment with Diazolin®, the use of alcoholic beverages is not recommended. The drug contains sucrose, which must be taken into account in patients with rare congenital fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency. Interaction with other drugs Diazolin® potentiates the action of hypnotics, sedatives and other drugs that depress the central nervous system, as well as alcohol. Contraindications Hypersensitivity to the components of the drug. Peptic ulcer of the stomach and duodenum during the period of exacerbation, inflammatory diseases of the gastrointestinal tract, pyloric stenosis, prostatic hyperplasia, angle-closure glaucoma, epilepsy, cardiac arrhythmias. Composition Active ingredient: mebhydrolin; 1 dragee contains mebhydrolin in terms of 100% dry matter 50 mg (0.05 g) or 100 mg (0.1 g); excipients: sucrose, starch syrup, talc, yellow wax, sunflower oil. Overdose Symptoms: confusion, drowsiness, impaired coordination of movement, depression of the function of the central nervous system (up to coma) or a stimulating effect on the central nervous system (more often in children); manifestations of anticholinergic action: dryness of the oral mucosa, dilated pupils, “flushing” of blood to the upper half of the body, nausea, vomiting, epigastric pain. Treatment, drug withdrawal, gastric lavage, activated charcoal, forced diuresis, symptomatic therapy. Side effect On the part of the digestive system: Diazolin® can irritate the mucous membranes of the gastrointestinal tract, which is sometimes manifested by dyspeptic symptoms (heartburn, nausea, pain in the epigastric region). From the side of the central nervous system: dizziness, paresthesia, fatigue, drowsiness, blurred vision, slow reactions, tremor, anxiety (at night). Others: dry mouth, urination disorders, allergic reactions. Rarely, granulocytopenia and agranulocytosis may occur. Children sometimes experience paradoxical reactions: irritability, tremors, sleep disturbances, irritability. In isolated cases in the post-registration period, the following adverse reactions were noted: headache, itching, rashes, urticaria, Quincke’s edema. In case of the listed adverse reactions, as well as reactions not mentioned in the instructions, you should consult a doctor. Storage conditions Store in a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Buy Diazolin dragee 0.05g 10×2