Desloratadine-LF capsules 5mg №10×1

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Desloratadine-LF caps 5 mg cont cell pack No. 10×1
Description:
Hard gelatin capsules of cylindrical shape with hemispherical ends with a body and a white cap. The main active ingredient Desloratadine Release formCapsules. Dosage 5 mg Pharmacological action Desloratadine is a long-acting antihistamine drug with a selective blocking effect on H1-histamine receptors. Does not penetrate the blood-brain barrier. It has a long antihistamine, anti-allergic and anti-inflammatory effect, does not cause a sedative effect. Indications for use Relief of symptoms of allergic rhinitis such as sneezing, nasal discharge, itching, swelling and nasal congestion, as well as itching and redness of the eyes, watery eyes, itching of the palate and coughing. Relief of symptoms associated with urticaria, such as itching and rash. and doses for oral administration. For relief of symptoms associated with allergic rhinitis (including intermittent and persistent) and urticaria, adults and children over 12 years of age take 1 capsule once daily, with or without food. In intermittent allergic rhinitis (symptoms less than 4 days or less than 4 weeks), therapy should be stopped after the symptoms disappear and resumed after their reappearance. In persistent allergic rhinitis (symptoms for more than 4 days or more than 4 weeks), treatment should be continued throughout the entire period of exposure to the allergen. Special Patient Populations Elderly Patients: The safety and efficacy of desloratadine in elderly patients has not been established. Patients with impaired renal function: In patients with severe renal insufficiency, desloratadine should be used with caution. Patients with hepatic impairment: There are no data on the use of desloratadine in patients with hepatic impairment. Use during pregnancy and lactation The safety of desloratadine during pregnancy has not been established, so it is not recommended to prescribe it during pregnancy. Desloratadine passes into breast milk, so the use of the drug in nursing women is not recommended. Influence on the ability to drive vehicles and control mechanisms The effect of desloratadine on the ability to drive a car and other mechanisms has not been established. However, in very rare cases, drowsiness is possible. The patient should be informed that in very rare cases dizziness has been observed in some patients, which may affect the ability to drive a car and other mechanisms. Precautions and special instructions Use the drug with caution in patients with severe renal insufficiency. In clinical studies, when prescribing desloratadine at a dose of 20 mg for 14 days, there were no statistically or clinically significant changes in the cardiovascular system. In a clinical pharmacological study, the use of desloratadine at a dose of 45 mg / day (9 times higher than therapeutic) for 10 days did not cause a prolongation of the QT interval on the ECG. When using the drug at the recommended dose of 5 mg, the frequency of drowsiness did not exceed that in the placebo group. In clinical studies, desloratadine did not affect psychomotor function at a dose of 7.5 mg. The efficacy and safety of desloratadine in children under 12 years of age have not been fully established. Interaction with other drugs Clinically significant changes in the plasma concentration of desloratadine with repeated co-administration with ketoconazole, erythromycin, azithromycin, fluoxetine, cimetidine were not found. Due to the fact that the enzyme responsible for the metabolism of desloratadine has not been established, interaction with other drugs cannot be completely excluded. In clinical and pharmacological studies, desloratadine did not increase the effects of alcohol, such as impaired psychomotor function and drowsiness. Psychomotor test results were not significantly different between patients treated with desloratadine and placebo alone or in combination with alcohol. Contraindications Hypersensitivity to the active substance or any of the components of the drug. Composition 1 capsule contains: Active substance: desloratadine – 5.0 mg. Excipients: microcrystalline cellulose, corn starch (modified Starch 1500), talc, calcium hydrogen phosphate dihydrate. The composition of the hard gelatin capsule: titanium dioxide (E 171), gelatin. Overdose Symptoms: increased side effects. Treatment: symptomatic. Standard measures are shown to remove unabsorbed active substance. Desloratadine is not excreted by hemodialysis, the possibility of excretion by peritoneal dialysis has not been established. Side effect The frequency of adverse reactions indicated below was determined using the following note: very often (> 1/10), often (> 1/100 – < 1/10), infrequently (> 1/1.000 – < 1/100), rarely (> 1/10.000 – < 1/1.000), very rare (< 1/10.000), not known (cannot be determined from the available data). According to data from clinical studies with the use of desloratadine according to indications for use, including allergic rhinitis and chronic idiopathic urticaria, at the recommended dose of 5 mg / day, the frequency of adverse events was 3% higher than with placebo. When using desloratadine, the most common (compared to placebo) adverse events were fatigue (1.2%), dry mouth (0.8%), headache (0.6%). Very rare side effects: Psychiatric disorders: hallucinations. Nervous system disorders: dizziness, drowsiness, insomnia, psychomotor hyperactivity, convulsions. Cardiovascular disorders: tachycardia, palpitations. Gastrointestinal disorders: nausea, stomach pain; diarrhea, vomiting, dyspepsia. Hepatobiliary disorders: increased activity of liver enzymes, increased bilirubin levels, development of hepatitis. Musculoskeletal and connective tissue disorders: myalgia General disorders: hypersensitivity reactions (anaphylaxis, angioedema, shortness of breath, itching, rash, urticaria). Storage conditions In a place protected from moisture and light at a temperature not exceeding 25? Keep out of the reach of children. Buy Desloratadine-LF capsules 5mg №10x1