Name:
Dermazin cream 50g Storage conditionsList B. The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life from the date of manufacture3 years
Description:
of goodsCream for external use 1% in the form of a homogeneous white mass. Pharmacological action Antimicrobial drug for external use, sulfanilamide. When applied to the surface of a burn, silver sulfadiazine decomposes, slowly and continuously releasing silver ions and sulfanilamide, which ensures inhibition of the growth and reproduction of bacterial cells. Dermazin has a wide spectrum of antibacterial activity, including virtually all types of microbes that cause infection of burns and other wounds on the skin surface (including Pseudomonas aeruginosa, Escherichia coli, Proteus spp., Staphylococcus spp., Streptococcus spp., Klebsiella spp., Enterobacter spp.), as well as yeast fungi (Candida albicans) and some strains of the herpes virus. Silver sulfadiazine penetrates into necrotic tissues and exudate. Pharmacokinetics Data on the pharmacokinetics of Dermazin are not available. Indications for use treatment and prevention of burn infections (including before autodermoplasty); treatment and prevention of infection of trophic ulcers, wounds. Pregnancy and lactation to save life exceeds the possible harm to the fetus. The use of sulfonamides increases the risk of developing hyperbilirubinemia, so Dermazin should not be prescribed, especially in the third trimester of pregnancy and during childbirth. The exception is when the potential benefit to save the patient’s life outweighs the risk to the fetus. It is not known whether silver sulfadiazine is excreted in human breast milk. However, other sulfonamides are found in milk. In addition, all sulfonamides increase the risk of developing hyperbilirubinemia. Due to the possibility of developing serious side effects in an infant when using sulfonamides in a nursing mother, if it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be considered, taking into account the degree of significance of treatment for the mother. Caution should be given to the drug in patients with hypersensitivity to sulfonamides due to the possibility of developing cross-sensitivity. As with other topical antimicrobials, superinfection may develop during treatment with silver sulfadiazine. Use with caution in patients with congenital deficiency of glucose-6-phosphate dehydrogenase due to the risk of hemolysis. With caution, prescribe the drug to patients with impaired liver and kidney function due to the possible accumulation of the drug due to delayed excretion. The question of the advisability of continuing therapy should be decided, taking into account the possible consequences of its withdrawal and the benefits of continuing. If treatment is continued, serum sulfadiazine concentrations should be monitored. When applying Dermazin to burn wounds of a large area, the concentration of sulfadiazine in serum can reach the therapeutic level when taken orally. In this case, it is necessary to control serum concentrations, monitor kidney function, and also monitor the possible content of sulfadiazine in the urine. With prolonged use of Dermazin on a large surface of the skin, the blood count should be monitored due to the possible development of leukopenia, thrombocytopenia or eosinophilia. The drug should not be used for porphyria. Avoid getting the cream in the eyes. Influence on the ability to drive vehicles and control mechanisms There was no effect of Dermazin on the ability to drive vehicles and control mechanisms. With caution (Precautions) With caution, prescribe the drug to patients with impaired liver function due to the possible accumulation of the drug due to delayed excretion. The question of the advisability of continuing therapy should be decided, taking into account the possible consequences of its withdrawal and the benefits of continuing. If treatment is continued, serum sulfadiazine concentrations should be monitored. Contraindications children’s age up to 2 months; premature newborns; the period of childbirth; hypersensitivity to the components of the drug; hypersensitivity to sulfonamides. Dosage and administration Dermazin can be used with or without dressings. The drug is intended for application to the skin only. After surgical treatment of the burn surface, the cream is applied to it with a layer 2-4 mm thick. The drug should be applied 1-2 times / day. Treatment should be continued until complete healing of the wound surface. The method of application of the cream is the same for the treatment of burns and trophic ulcers. Bandages should be changed daily. OverdoseSymptoms: with prolonged use on a large surface of the body, serum concentrations of sulfadiazine may approach the level achieved with systemic use, which increases the risk of developing adverse reactions characteristic of sulfonamides. Argyria does not develop due to increased systemic absorption of silver. Treatment: symptomatic therapy, determination of the serum concentration of sulfanilamide, drinking plenty of fluids (it is recommended to maintain a daily diuresis of 1200-1500 ml or more). Side effects Local reactions: rarely – burning sensation, itching. On the part of the hematopoietic system: in some cases, the development of transient leukopenia (mainly a decrease in the number of neutrophils) was noted in patients treated with silver sulfadiazine. The maximum decrease in the level of leukocytes is observed 2-4 days after the start of treatment. Then their level is normalized within 2-3 days, while continued treatment with silver sulfathiazine does not affect the process of restoring the number of leukocytes. There are separate reports of the development of skin necrosis, erythema multiforme, skin pigmentation disorders, interstitial nephritis. The degree of absorption of silver sulfadiazine depends on the size of the burn surface and the degree of tissue damage. In rare cases, any adverse reactions characteristic of sulfonamides may develop: hematopoietic disorders (including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, hemolytic anemia), skin and allergic reactions (including Stevens-Johnson syndrome and exfoliative dermatitis), dyspepsia, hepatitis, hepatocellular necrosis, reactions from the central nervous system, toxic nephrosis. Composition of silver sulfadiazine 10 mg. Excipients: cetyl alcohol, peanut oil (hydrogenated), polysorbate 60, propylene glycol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, purified water. Drug Interactions Silver sulfadiazine may inactivate wound cleansing enzyme preparations when used concomitantly. It is noted that with the simultaneous use of cimetidine, the risk of developing leukopenia increases. Release formCream for external use 1% in the form of a homogeneous white mass. 1 g silver sulfadiazine 10 mg Excipients: cetyl alcohol, peanut oil (hydrogenated), polysorbate 60, propylene glycol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, purified water. 50 g – aluminum tubes (1) – packs of cardboard. Buy Dermazin cream 1% 50g №1 Price for Dermazin cream 1% 50g №1 Instructions for use for Dermazin cream 1% 50g №1
INN | SULFADIAZINE |
---|---|
The code | 47 405 |
Barcode | 3 838 957 900 664 |
Dosage | 1% 50g |
Active substance | Silver sulfadiazine |
Manufacturer | Salutas Pharma GmbH, Germany |
Importer | IOOO Interfarmaks 223028 Minsk region, Minsk district, Zhdanovichsky s / s, ag. Zhdanovichi, st. Star, 19a-5, room. 5-2 |
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