Complivit tablets p / o No. 60

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Complivit tab p / o in jars No. 60 in pack No. 1
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Tablets are biconvex, round, film-coated, white, with a characteristic odor. The cross section shows two layers. The main active ingredientPolyvitamin + multimineral Release formtablets Pharmacological propertiesPharmacodynamicsCombined preparation containing a complex of vitamins and minerals, which are important factors in metabolic processes. The compatibility of the components in 1 tablet is ensured by a special production technology for vitamin preparations. Retinol (vitamin A) is involved in the formation of visual pigments, is necessary for twilight and color vision; ensures the integrity of epithelial tissues, regulates bone growth. Thiamine (vitamin B1) as a coenzyme is involved in carbohydrate metabolism, the functioning of the nervous system. Riboflavin (vitamin B2) is the most important catalyst for cellular respiration and visual perception. Pyridoxine (vitamin B6) as a coenzyme takes part in protein metabolism and the synthesis of neurotransmitters. Cyanocobalamin (vitamin B12) is involved in the synthesis of nucleotides, is an important factor in the normal growth, hematopoiesis and development of epithelial cells; essential for folic acid metabolism and myelin synthesis. Nicotinamide is involved in the processes of tissue respiration, fat and carbohydrate metabolism. Ascorbic acid (vitamin C) provides collagen synthesis; participates in the formation and maintenance of the structure and function of cartilage, bones, teeth; affects the formation of hemoglobin, the maturation of red blood cells. Rutoside (rutin) is involved in redox processes, has antioxidant properties, prevents oxidation and promotes the deposition of ascorbic acid in tissues. Calcium pantothenate as a component of coenzyme A plays an important role in the processes of acetylation and oxidation; promotes the construction, regeneration of the epithelium and endothelium. Folic acid takes part in the synthesis of amino acids, nucleotides, nucleic acids; essential for normal erythropoiesis. Lipoic acid is involved in the regulation of lipid and carbohydrate metabolism, has a lipotropic effect, affects cholesterol metabolism, and improves liver function. a-tocopherol acetate (vitamin E) has antioxidant properties, maintains the stability of red blood cells, prevents hemolysis; has a positive effect on the functions of the gonads, nervous and muscle tissue. Iron is involved in erythropoiesis, as part of hemoglobin, it provides oxygen transport to tissues. Copper prevents the development of iron deficiency anemia and oxygen starvation of organs and tissues, contributes to the prevention of osteoporosis. Increases the strength and elasticity of blood vessels by acting on connective tissue proteins. Calcium is necessary for the formation of bone substance, blood clotting, the process of transmission of nerve impulses, contraction of skeletal and smooth muscles, and normal myocardial activity. Cobalt regulates metabolic processes, increases the body’s defenses. Manganese plays an important role in metabolism, is part of many enzymes, strengthens; bone and cartilage tissue. Zinc has immunomodulatory properties, promotes the absorption of vitamin A, regeneration and hair growth. Magnesium contributes to the normalization of blood pressure, stimulates, together with calcium, the production of calcitonin and parathyroid hormone, and prevents the deposition of calcium salts in the kidneys. Phosphorus strengthens bone tissue and teeth, enhances mineralization, is part of ATP – the energy source of cells. Pharmacokinetics Water-soluble vitamins (vitamins of group B, vitamin C, thioctic acid) and minerals are well absorbed in amounts corresponding to the daily needs of the body. Amounts exceeding the tissue saturation level are excreted in the urine, sometimes in the feces. Regular intake of vitamins and minerals is important to maintain the necessary concentrations in the tissues, since they accumulate in the body in limited quantities. After oral administration, fat-soluble vitamins A and E are well absorbed in the small intestine in the presence of fat. Removal of fat-soluble vitamins from the body is slow, when high doses enter the body, cumulation is possible. Indications for use Replenishment of vitamin and mineral deficiencies when the need for them cannot be met by the composition of the diet. Dosage and administration Take orally after meals. For the prevention of vitamin and mineral deficiency – 1 tablet 1 time per day. In conditions accompanied by an increased need for vitamins and minerals – 1 tablet 2 times a day. The course of treatment is 4 weeks. Repeated courses – on the recommendation of a doctor. Use during pregnancy and lactation The use of the drug during pregnancy and during breastfeeding is contraindicated. Precautions It is possible to stain urine in an intense yellow color, which is due to the presence of riboflavin in the composition of the drug and is not dangerous. Simultaneous administration with other preparations containing vitamins and minerals is not recommended. Patients with diabetes should take into account that the sugar content in Complivit® is 184.78 mg (in 1 tablet). Taking vitamins does not replace a balanced diet. Do not exceed the indicated dosage. High doses of some components can be hazardous to health. This medicinal product should be used with caution in patients who have experienced hypersensitivity reactions to azo dyes, acetylsalicylic acid and other prostaglandin inhibitors, and other multivitamin preparations. It is prescribed with caution for liver damage, a history of peptic ulcer of the stomach and duodenum, cholelithiasis, chronic pancreatitis, diabetes mellitus, and the presence of neoplasms. Vitamin C can interfere with test results for urine glucose, uric acid, and serum creatinine. Taking higher doses of folic acid, vitamin B12, and iron may mask some forms of anemia. Interaction with other drugs While taking the drug, you should refrain from taking alcohol, since alcohol reduces the absorption of some vitamins. Vitamins A and E mutually reinforce the action and are synergists. Retinol reduces the anti-inflammatory effect of glucocorticoids. Nitrites and cholestyramine disrupt the absorption of retinol, so their simultaneous use with the drug is not recommended. To avoid the possibility of developing hypervitaminosis A, the combined use of the drug with other drugs containing vitamin A is not recommended. Vitamin A is not prescribed simultaneously with retinoids, their combination is toxic. Vitamin C increases the absorption of iron, enhances the toxicity of sulfonamides (the possibility of crystalluria), penicillins, reduces the effectiveness of heparin and indirect coagulants. The absorption of vitamin C decreases with simultaneous use with oral contraceptives. The simultaneous use of ascorbic acid with antacids containing aluminum may increase the excretion of aluminum in the urine. Therefore, the combined use of antacids and COMPLIVIT is not recommended, especially in patients with renal insufficiency. The combined use of salicylates with ascorbic acid may increase the urinary excretion of ascorbic acid. Vitamin B2 is not compatible with streptomycin, reduces the effectiveness of antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). Therefore, it should be taken at least 3 hours before taking an antibiotic. The tricyclic antidepressants, imipramine and amitriptidine, inhibit riboflavin metabolism, especially in cardiac tissues. Vitamin B6 affects the metabolism of certain drugs. High doses of vitamin B6 reduce the antiparkinsonian effect of levodopa. Pyridoxine enhances the peripheral conversion of levodopa and thus reduces its effectiveness in the treatment of Parkinson’s disease. Vitamin B6 is an antagonist of isoniazid and thiosemicarbazones, correcting sideroblastic anemia caused by these anti-tuberculosis drugs. The amount of vitamin B6 is reduced when taken simultaneously with oral contraceptives. Vitamin B6 affects the processes of polarization in the area of neuromuscular synapses, therefore, it can weaken the curare-like effect. Large doses of pyridoxine may lead to a decrease in serum concentrations of phenytoin and phenobarbital in some patients. Colchicine, cimetidine, calcium preparations, ethyl alcohol, neomycin, para-aminosalicylic acid, biguanides, cholestyramine, potassium chloride and methyldopa reduce the absorption of vitamin B12. Chloramphenicol and vitamin C affect the absorption of vitamin B12. Serum concentrations of cyanocobalamin may be reduced while taking oral contraceptives. Folic acid can reduce plasma concentrations of anticonvulsants, in particular phenytoin, phenobarbital and primidone, resulting in a mutual decrease in clinical efficacy. Therefore, patients receiving antiepileptic therapy may require dose adjustments and close medical supervision when taking folic acid. Preparations containing folic acid or its derivatives may reduce the effectiveness of methotrexate. Antibodies that cross-react with other folic acid analogues, including methotrexate, folinic acid (leucovorin), and aminopterin, have been found in patients with hypersensitivity to folic acid. ContraindicationsIndividual intolerance to the components of the drug, children under 15 years of age. Composition Excipients (core): talc (E 553) – 5.07 mg, potato starch – 14.05 kg, citric acid (in the form of citric acid monohydrate) (E 330) – 14.14 mg, povidone (low molecular weight polyvinylpyrrolidone, povidone K-17) (E 1201) – 1.60 mg, collicoate® Protect (macrogol and polyvinyl alcohol copolymer 55-65%, polyvinyl alcohol 35-45%, silicon dioxide 0.1-0.3%) – 0.32 mg, calcium octadecanoate (calcium stearate) (E 470) – 5.04 mg, sucrose (granulated sugar) – 27.10 mg. Excipients (shell): wheat flour – 71.40 mg, magnesium hydroxycarbnate (magnesium carbonate basic water) – 93.33 mg, gelatin – 0.54 mg, titanium dioxide (E.171) – 4.59 mg, talc ( E 553) – 0.33 mg, beeswax (E 901) – 0.33 mg, water-soluble methylcellulose (E 461) – 1.80 mg, sucrose (granulated sugar) – 157.68 mg. Overdose With prolonged use, significantly exceeding the recommended course of 4 weeks, and exceeding the recommended daily dose, the following conditions may occur: impaired glucose tolerance, drowsiness, paresthesia, visual disturbances, arrhythmias, discoloration of urine, hypercalciuria, hemolytic anemia (in some patients with deficiency glucose-6-phosphate dehydrogenase), hyperthermia, irritability, hyperhidrosis, temporary increase in aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase. In case of overdose, you should consult a doctor. Treatment: temporary discontinuation of the drug, oral activated charcoal, gastric lavage, symptomatic treatment. Side effects The recommended doses are usually well tolerated. Some individuals may experience adverse reactions: On the part of the immune system: hypersensitivity reactions to the components of the drug are possible, including anaphylactic shock, bronchospasm. From the nervous system: headache, dizziness. From the digestive tract: gastrointestinal disorders, dyspepsia, constipation, diarrhea, increased secretion of gastric juice. From the skin and subcutaneous tissue: rash, urticaria, itching, redness. Storage conditions At a temperature not higher than 25 °C. Store in original packaging to protect from moisture and light. Keep out of the reach of children. Buy Complivit tablets p / o No. 60 Price for Complivit tablets p / o No. 60