Name:
Ciprolet eye drops (aqueous) 3mg/ml in vial. 5ml No. 1
Description:
Eye drops are colorless or light yellow, transparent. The main active ingredient Ciprofloxacin Release form The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25 ° C; do not freeze. The drug should be used within 1 month after opening the vial. Dosage 3mg/ml in vial 5ml No. 1 Special instructions Eye drops can only be applied topically, you can not inject the drug subconjunctivally or into the anterior chamber of the eye. When using Tsiprolet® eye drops and other ophthalmic solutions, the interval between their injections should be at least 5 minutes. It is not recommended to wear contact lenses during treatment with the drug. Influence on the ability to drive vehicles and control mechanisms Patients who temporarily lose their vision after application are not recommended to drive a car or work with complex machinery or any complex equipment that requires clarity of vision immediately after instillation of the drug. Pharmacological action Broad-spectrum antimicrobial drug, a fluoroquinolone derivative. Suppresses bacterial DNA gyrase (topoisomerases II and IV, responsible for the process of supercoiling of chromosomal DNA around nuclear RNA, which is necessary for reading genetic information), disrupts DNA synthesis, growth and division of bacteria; causes pronounced morphological changes (including the cell wall and membranes) and rapid death of the bacterial cell. It acts bactericidal on gram-negative organisms during dormancy and division (because it affects not only DNA gyrase, but also causes lysis of the cell wall), it acts on gram-positive microorganisms only during division. Low toxicity to macroorganism cells is explained by the absence of DNA gyrase in them. Against the background of the use of ciprofloxacin, there is no parallel development of resistance to other antibiotics that do not belong to the group of DNA gyrase inhibitors, which makes it highly effective against bacteria that are resistant, for example, to aminoglycosides, penicillins, cephalosporins, tetracyclines and many other antibiotics. Gram-negative aerobic bacteria are sensitive to ciprofloxacin: enterobacteria (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp. , Morganella morganii, Vibrio spp., Yersinia spp.); other Gram-negative bacteria (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.); some intracellular pathogens: Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Corynebacterium diphtheriae; Gram-positive aerobic bacteria: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae). Most methicillin-resistant staphylococci are also resistant to ciprofloxacin. The sensitivity of Streptococcus pneumoniae, Enterococcus faecalis, Mycobacterium avium (located intracellularly) is moderate (high concentrations are required to suppress them). Resistant to the drug: Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Not effective against Treponema pallidum. Resistance develops extremely slowly, because, on the one hand, after the action of ciprofloxacin, there are practically no persistent microorganisms left, and on the other hand, bacterial cells do not have enzymes that inactivate it. Pharmacokinetics Absorption After application of eye drops Cmax of ciprofloxacin in plasma is less than 5 ng / ml. The average concentration is below 2.5 ng / ml. After instillation, systemic absorption of the drug is possible. Excretion Ciprofloxacin is excreted by the kidneys mainly unchanged (50%) in the form of metabolites (up to 10%), about 15% is excreted through the intestines. It is allocated with breast milk. Indications for use Treatment of infectious and inflammatory diseases of the eye and its appendages caused by bacteria sensitive to the drug: acute and subacute conjunctivitis; blepharoconjunctivitis, blepharitis; bacterial ulcers of the cornea; bacterial keratitis and keratoconjunctivitis; chronic dacryocystitis and meibomitis. Preoperative prophylaxis in ophthalmic surgery. Treatment of postoperative infectious complications. Treatment and prevention of infectious complications of the eyes after injuries or foreign bodies. Dosage and administration Apply topically. For mild and moderately severe infections, 1-2 drops are instilled into the conjunctival sac of the affected eye every 4 hours, for severe infections, 2 drops every hour. After improvement of the condition, the dose and frequency of instillations are reduced. With a bacterial corneal ulcer, 1 drop is prescribed every 15 minutes for 6 hours, then 1 drop every 30 minutes during waking hours; on day 2 – 1 drop every hour during waking hours; from 3 to 14 days – 1 drop every 4 hours during waking hours. If after 14 days of therapy epithelialization has not occurred, treatment can be continued. Use during pregnancy and lactationTsiprolet® is contraindicated during pregnancy and lactation (breastfeeding). Precautions The drug should be used with caution in patients with cerebral atherosclerosis, cerebrovascular accident, convulsive syndrome. Interaction with other drugs When combined with the drug Ciprolet® with other antimicrobial agents (beta-lactam antibiotics, aminoglycosides, clindamycin, metronidazole), synergism is usually observed. Ciprolet® can be successfully used in combination with azlocillin and ceftazidime in infections caused by Pseudomonas spp.; with mezlocillin, azlocillin and other beta-lactam antibiotics – for streptococcal infections; with isoxazolpenicillins and vancomycin – with staphylococcal infections; with metronidazole and clindamycin – for anaerobic infections. Pharmaceutical interactions Ciprofloxacin solution is pharmaceutically incompatible with drugs with a pH value of 3-4 that are physically or chemically unstable. Contraindications Viral keratitis; pregnancy; lactation period (breastfeeding); children’s age up to 1 year; hypersensitivity to the components of the drug; hypersensitivity to other drugs of the quinolone group. With caution, the drug should be used in patients with cerebral atherosclerosis, cerebrovascular accident, convulsive syndrome. Composition Active substance: ciprofloxacin hydrochloride 3.49 mg, which corresponds to the content of ciprofloxacin 3 mg; Excipients: disodium edetate – 0.5 mg, sodium chloride – 9 mg, benzalkonium chloride 50% solution – 0.0002 ml, hydrochloric acid – 0.000034 mg, water for injection – up to 1 ml. Overdose There are no data on overdose of the drug Ciprolet® when applied topically. Symptoms: in case of accidental ingestion of the drug, there are no specific symptoms. Nausea, vomiting, diarrhea, headache, fainting, anxiety may occur. Treatment: standard emergency measures, adequate fluid intake, making urine acidic to prevent crystalluria. Side effect On the part of the organ of vision: itching, burning, mild soreness and hyperemia of the conjunctiva; rarely – swelling of the eyelids, photophobia, lacrimation, sensation of a foreign body in the eyes, decreased visual acuity, the appearance of a white crystalline precipitate in patients with corneal ulcers, keratitis, keratopathy, corneal infiltration. Other: allergic reactions, nausea; rarely – an unpleasant aftertaste in the mouth immediately after instillation, the development of superinfection. Storage conditionsStore below 25°C, protected from light. Do not freeze. Keep out of the reach of children. Buy Ciprolet eye drops 3mg/ml 5ml №1 Price for Ciprolet eye drops 3mg/ml 5ml №1Instruction for use for Ciprolet eye drops 3mg/ml 5ml №1
Ciprolet eye drops 3mg/ml 5ml №1
$14.00
SKU: 3231
Category: Medicines for diseases of the eyes and ears
INN | CIPROFLOXACIN |
---|---|
The code | 3 231 |
Barcode | 8 901 148 209 008 |
Dosage | 3mg/1ml 5ml |
Active substance | Ciprofloxacin |
Manufacturer | Ahlcon Parenterals (India) Ltd., India |
Importer | IOOO Interfarmaks 223028 Minsk region, Minsk district, Zhdanovichsky s / s, ag. Zhdanovichi, st. Star, 19a-5, room. 5-2 |
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