Name:
Ciprofloxacin solution (to-li ch.) 3mg/ml vial 5ml with cr-cap in pack No. 1
Description:
Transparent colorless or slightly greenish solution. The main active ingredient Ciprofloxacin Release form Eye drops Dosage 3 mg / ml Pharmacological action Antimicrobial drug. Acts bactericidal. While taking ciprofloxacin, there is no parallel development of resistance to aminoglycosides, penicillins, cephalosporins, tetracyclines. Ciprofloxacin has shown high activity in in vitro studies against many gram-negative microorganisms, including Pseudomonas aeruginosa. It is also effective against gram-positive bacteria such as staphylococci and streptococci. Anaerobic bacteria are generally less sensitive. In in vitro and in vivo studies, the activity of ciprofloxacin was established against the following microorganisms (MIC ≤ 1 μg / ml): Gram-positive: Staphylococcus aureus (methicillin-sensitive), Staphylococcus epidermidis (methicillin-sensitive), Streptococcus pneumoniae, Streptococcus (Viridans group) . Gram-negative: Acinetobacter sp, Haemophilus sp., Pseudomonas aeruginosa, Serratia marcescens. In vitro studies have shown activity of ciprofloxacin against most strains of the following microorganisms, although the clinical significance of these data has not been established: Gram-positive: Bacillus cereus, Corynebacterium sp., Enterococcus faecalis (many strains are moderately susceptible), Micrococcus sp., Staphylococcus capitis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus warneri, Streptococcus pyogenes. Gram-negative: Aeromonas caviae, Aeromonas hydrophila, Brucella melitensis, Campylobacter coli, Campylobacter jejuni, Citrobacter sp., Edwardsiella tarda, Enterobacter sp., Escherichia coli, Haemophilus parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumophila, Moraxella sp., Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Providencia sp., Salmonella enteritidis, Salmonella typhi, Shigella sonneii, Shigella flexneri, Vibrio cholera, Vibrio parahaemolyticus, Vibrio vulnificus, Yersinia enterocolitica. Other organisms: Chlamydia trachomatis and Mycobacterium are only moderately sensitive (MIC > 1 µg/mL, < 2 µg/mL). Most strains of Pseudomonas cepacia and some strains of Pseudomonas maltophilia are resistant to ciprofloxacin, as are most anaerobic bacteria, including Bacteroides fragilis and Clostridium difficile (MIC > 4 µg/mL). Controlled clinical trials to study the effectiveness of the drug in chlamydial infection have not been conducted. Therefore, the drug is not suitable for the treatment of chlamydial infection. Indications for use Superficial infectious and inflammatory diseases of the eyes, such as conjunctivitis, blepharitis and blepharoconjunctivitis; bacterial corneal ulcers caused by microorganisms susceptible or suspected to be susceptible to ciprofloxacin, in particular Pseudomonas aeruginosa and other gram-negative pathogens resistant to standard treatments. Dosage and administration Dosage and administration ? wash your hands before instillation; ? tilt your head back; ? lower the edge of the lower eyelid with your finger until a “pocket” is formed between the eyelid and your eye; ? without touching the eye or eyelid, adjacent areas or other surfaces with parts of the dropper, drop the drug into the formed “pocket” in the amount of kazel indicated in the instructions; ? if necessary, repeat the steps for the other eye; if you missed the instillation time, do not use a double dose, just use the drug when the next due date comes; ? if you accidentally instill more ciprofloxacin than required by the instructions, rinse your eye with warm water. Adults and children over 1 year of age: Superficial bacterial infections of the eye and its appendages (bacterial conjunctivitis/blepharitis): ? one ? Day 2: 1 2 drops during the day every 2 hours in the conjunctival sac of inflamed eyes; ? 3? Day 7: every 4 hours, 1 ? 2 drops are instilled into the conjunctival sac of inflamed eyes. If longer treatment is required, the dose is determined by the doctor. With a bacterial ulcer of the cornea, 2 drops of the drug are instilled every 15 minutes for 6 hours, then ? 2 drops every 30 minutes during waking hours on the 1st day; on day 2? 2 drops every hour during waking hours; 3 to 14 days? 2 drops every 4 hours during waking hours. If after 14 days of therapy epithelialization has not occurred, treatment can be continued. The maximum duration of treatment for any of the diagnoses? 21 day. Elderly patients. The efficacy and safety of ciprofloxacin eye drops do not differ between older and younger patients. Children. For children under 1 year of age, the safety and efficacy of the drug has not been established. Although oral ciprofloxacin and other fluoroquinolones cause arthropathy in young animals, ciprofloxacin does not cause arthropathy when instilled into the eye, and there is no evidence of an effect of ophthalmic doses on the supporting joints of young animals. Use during pregnancy and lactation The use of the drug during pregnancy and lactation is contraindicated (breastfeeding should be stopped for the period of treatment). Influence on the ability to drive vehicles and other potentially dangerous mechanisms Patients who, after using ciprofloxacin in the form of eye drops, temporarily lose their vision, are not recommended to drive a car or work with complex equipment immediately after instillation of the drug. Precautions After instillation of the solution into the eyes to reduce systemic absorption, it is recommended: hold the eyelid closed for 2 minutes; ? squeeze the tear duct with your finger for 2 minutes. This medicine contains benzalkonium chloride, which may cause eye irritation. Since hypersensitivity reactions cannot be excluded during treatment, the drug should be discontinued at the first sign of redness or other symptoms of hypersensitivity. Do not use the drug for infections associated with deeper structures of the eye. Serious, life-threatening anaphylactic-type hypersensitivity reactions have been reported following systemic administration of quinolones. Reactions are manifested by cardiovascular disorders, loss of consciousness, swelling of the pharynx or face, shortness of breath, urticaria and itching. Only a small proportion of these patients had a history of hypersensitivity reactions. Serious anaphylactic reactions require immediate emergency care with the introduction of adrenaline and other resuscitation measures. As with other antibacterial agents, long-term use of ciprofloxacin may lead to the development and growth of resistant strains of bacteria or fungi. In case of superinfection, appropriate therapy should be initiated. When prescribing eye drops containing antimicrobial agents, one should take into account the possible nasopharyngeal passage, which can lead to the development and spread of bacterial resistance. The drug can only be applied topically; it should not be injected subconjunctivally or directly into the anterior chamber of the eye. When using other ophthalmic drugs, the interval between their administration should be at least 15 minutes. During treatment with the drug, it is not recommended to wear soft contact lenses. When using hard contact lenses, remove them before instillation and put them back on after 15? 20 minutes after instillation of the drug. The bottle must be closed after each use. Do not touch the tip of the pipette to the eye. The drug should be used with caution in patients with cerebral atherosclerosis, cerebrovascular accident, convulsive syndrome, with known risk factors for prolongation of the QT interval. Patients should be aware that if conjunctival hyperemia continues or increases after the use of drops for a long time, stop using the drug and consult a doctor. Interaction with other drugs No interaction studies of ciprofloxacin in the form of eye drops with other drugs have been conducted. With the systemic administration of some quinolones, an increase in the plasma concentration of theophylline, an effect on the metabolism of caffeine, and an increase in the effects of oral anticoagulants, warfarin and its derivatives were observed. In addition, there was a transient increase in serum creatinine in patients who simultaneously received cyclosporine. Incompatibility: Ciprofloxacin in the form of eye drops is incompatible with alkaline solutions. Contraindications Hypersensitivity to ciprofloxacin or other drugs of the quinolone group, hypersensitivity to the auxiliary components of the drug, viral and fungal eye infections, glucose-6-phosphate dehydrogenase deficiency, pregnancy and lactation (breastfeeding should be stopped for the period of treatment), children under 1 year of age ( for eye drops). One vial contains: active ingredient: ciprofloxacin (as ciprofloxacin hydrochloride) 15.0 mg; excipients: mannitol (mannitol), benzalkonium chloride, sodium acetate trihydrate, disodium edetate (E 386), glacial acetic acid, water for injection. Overdose Data on drug overdose are not available. In case of an overdose of the drug when applied topically, the excess solution should be removed by rinsing the eyes with plenty of warm running water. Side effects Allergic reactions, itching, burning, mild soreness and hyperemia of the conjunctiva, nausea; rarely ? eyelid edema, photophobia, lacrimation, sensation of a foreign body in the eyes, an unpleasant aftertaste in the mouth immediately after instillation, decreased visual acuity, the appearance of a white crystalline precipitate in patients with corneal ulcer, keratitis, keratopathy, the appearance of spots or infiltration of the cornea, the development of superinfection, prolongation of the interval QT on the electrocardiogram. In case of adverse reactions, including those not listed in this leaflet, you should consult a doctor. Storage conditions Store in a place protected from light at a temperature not exceeding 25 ° C. Store the opened vial in a place protected from light at a temperature of 15 ° C to 25 ° C for 4 weeks. Keep out of the reach of children. Do not use the medicinal product after the expiration date. Buy Ciprofloxacin eye drops 3mg/ml 5ml №1 Price for Ciprofloxacin eye drops 3mg/ml 5ml №1
Ciprofloxacin eye drops 3mg/ml 5ml №1
$8.00
SKU: 86085
Category: Medicines for diseases of the eyes and ears
INN | CIPROFLOXACIN |
---|---|
The code | 86 085 |
Barcode | 4 810 133 009 803 |
Dosage | 3mg/ml 5ml |
Active substance | Ciprofloxacin |
Manufacturer | Belmedpreparaty RUE, Belarus |
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