Name:
Anauran ear drops. in fl. 25ml No. 1 Composition 100 ml of solution contains active substances: polymyxin B sulfate – 1000000 IU, neomycin sulfate – 0.5 g (equivalent to 375000 IU), lidocaine hydrochloride – 4.0 g; excipients: benzalkonium chloride – 0.01 g, propylene glycol – 44 ml, glycerol – 26.5 ml, purified water – up to 100 ml.
Description:
Slightly viscous, clear, colorless, odorless liquid. Pharmacotherapeutic groupMeans used in otology. Anti-infective agents. ATC code: S02AA30. Pharmacological properties Pharmacodynamics Neomycin sulfate is a broad-spectrum aminoglycoside antibiotic that acts bactericidal against gram-positive (Staphylococcus spp., Streptococcus pneumoniae) and gram-negative (Escherichia coli, Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Proteus spp.) microorganisms; against Streptococcus spp. – inactive. Polymyxin B is a polypeptide antibiotic. Active against gram-negative microorganisms: Escherichia coli, Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Salmonella typhi and Salmonella paratyphi; Pseudomonas aeruginosa. Not active against Proteus spp., Mycobacterium spp., Gram-positive cocci, fungi. It has a weak local irritant effect. Lidocaine is a local anesthetic that quickly relieves pain and itching. Pharmacokinetics Pharmacokinetic studies have not been conducted, tk. the drug is intended for topical use and systemic effects are unlikely. Indications for use Acute and chronic otitis. Dosage and administration Locally, in the external auditory canal using a special pipette. After instillation, keep your head tilted for several minutes. Adults: 4-5 drops 2-4 times a day, children: 2-3 drops 3-4 times a day, depending on the severity of the disease. The course of treatment should not exceed 10 days. The drug Anauran in children under 1 year should be used only in case of emergency and under the supervision of a physician. Side effects Possible local allergic reactions: hyperemia, itching and peeling of the skin of the external auditory canal, which disappear without treatment, after discontinuation of the drug. Systemic effects are unlikely due to the low doses of the drug used. However, with long-term treatment, systemic effects may occur, in particular, ototoxicity and nephrotoxicity due to the absorption of neomycin. If the listed adverse reactions occur, as well as reactions not mentioned in the instructions for medical use, the patient should consult a doctor. Contraindications in patients with hypersensitivity to polymyxin B sulfate, neomycin sulfate, lidocaine hydrochloride and chemically related compounds or to any of the excipients. Patients with perforation of the tympanic membrane, given the risk of developing ototoxicity. Precautions Prolonged treatment with topical preparations may cause sensitization. In this case, it is necessary to suspend treatment and consult a doctor to prescribe the appropriate treatment. In severe and persistent infections, topical treatment should be supplemented with systemic antibiotics. Prolonged use of Anauran, as well as other antibiotics, can lead to the development of superinfection with drug-resistant microorganisms. Neomycin can cause permanent sensorineural hearing loss due to damage to the organ of Corti in the cochlea. The risk of developing ototoxicity increases with increasing duration of therapy, so the recommended duration of Anauran therapy is limited to 10 days. Perhaps the development of cross-allergy and resistance with other drugs derivatives of aminoglycosides. Anauran is used exclusively for ear diseases. Anauran contains benzalkonium chloride, which may cause skin irritation or skin reactions, and propylene glycol, which may also cause skin irritation. Influence on the ability to drive vehicles or other mechanisms Anauran does not affect the ability to drive vehicles or other mechanisms. Interaction with other drugs Incompatible with monomycin, streptomycin, gentamicin, amikacin, netilmicin (possibly increased ototoxic effect of the above antibiotics). Pregnancy and lactation During pregnancy and lactation, the drug should be used only if absolutely necessary and under medical supervision. Conditions and shelf life At temperatures from 15°C to 25°C. Store the opened vial at a temperature of 15°C to 25°C. Keep out of the reach of children. Shelf life 3 years. After opening the vial, the drug can be used within 3 months. Do not use after the expiry date stated on the package. Terms of release Released by prescription. Packing Ear drops. 25 ml in a dark glass bottle with a polyethylene dropper cap with first opening control. One vial with instructions for medical use is placed in a cardboard box. Buy Anauran ear drops 25ml №1 Price for Anauran ear drops 25ml №1Instruction for use for Anauran ear drops 25ml №1
INN | LIDOCAINE+NEOMYCIN+POLYMYXIN B |
---|---|
The code | 34 686 |
Barcode | 4 603 619 000 070 |
Dosage | 25ml |
Active substance | neomycin, polymyxin b, lidocaine |
Manufacturer | Zambon S.P.A., Italy |
Importer | Closed joint-stock company "Unipharm", 223060, Minsk region, Novodvorsky s / council, 40-1, room. 36, area of the village of Bolshoye Stiklevo; LLC "LIGMATON", Republic of Belarus, Minsk region, Minsk district, Senitsky s / s, 68/3-3, Senitsa district., 223056 |
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