Amoxicillin capsules 250mg №10×3

Name Amoxicillin caps. With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, additional methods of contraception should be used whenever possible. In patients with severely impaired renal function, a dose reduction may be required. Features of the use of the drug in pediatric practice: Contraindicated in children under 6 years of age (for this dosage form) Features of the use of the drug in geriatric practice: Dose adjustment in elderly patients is not required. However, in elderly patients, a decrease in renal function is more likely, therefore care should be taken in choosing a dose and monitoring renal function due to the potential risk of developing toxic reactions. Pharmacological action Semi-synthetic penicillin, has a bactericidal effect, has a wide spectrum of action. It inhibits transpeptidase, disrupts the synthesis of peptidoglycan during division and growth, causes bacterial lysis. Active against gram-positive and gram-negative cocci, some gram-negative rods. Acts on Staphylococcus spp., except for penicillinase-producing strains, Streptococcus spp., Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Proteus mirabilis, some strains of Salmonella, Shigella Klebsiella and Haemophilus influenzae. In combination with metronidazole, it is active against Helicobacter pylori. Is it destroyed? – lactamase, so the microorganisms-producers? – lactamases are resistant to the action of amoxicillin. Pharmacokinetics When taken orally, it is absorbed quickly and almost completely (93%). Stable in an acidic environment, food intake does not affect absorption. The maximum plasma concentration (3.5-5 μg / ml) is created 1-2 hours after ingestion of 0.25 g of amoxicillin. Penetrates into most tissues and organs. Accumulates at therapeutic concentrations in peritoneal fluid, urine, skin blisters, pleural effusions, lungs (but not in purulent bronchial secretions), intestinal mucosa, female genital organs, middle ear fluid, gallbladder and bile (with normal liver function), fetal tissues. Easily passes histohematic barriers (with the exception of the unchanged blood-brain barrier). With inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the plasma level. The half-life corresponds to 1-1.5 hours, in case of impaired renal function, the half-life is extended to 4-12.6 hours. Partially metabolized to form inactive metabolites. It is excreted by the kidneys unchanged (50-70%) and with bile (10-20%). A small amount is excreted in breast milk. Indications for use Infectious and inflammatory diseases caused by susceptible microorganisms, including bronchitis, pneumonia, tonsillitis, acute otitis media, pharyngitis, sinusitis, urethritis, cystitis, pyelonephritis, endometritis, uncomplicated gonorrhea, infections of the skin and soft tissues, gastrointestinal tract ( peritonitis, enteritis, cholecystitis, cholangitis), leptospirosis, listeriosis, borreliosis, meningitis, prevention of bacteremia, bacterial endocarditis associated with surgical procedures (in particular dental), in patients at risk of developing bacterial endocarditis; combined therapy of peptic ulcer of the stomach and duodenum associated with Helicobacter pylori (in combination with metronidazole or clarithromycin and antisecretory drugs), sepsis (together with aminoglycosides); treatment and prevention of anthrax. Dosage and administration The drug is taken orally. Adults and children over 10 years old (weighing over 40 kg) are prescribed 0.5 g (2 capsules) 3 times a day; in severe infections, the dose is increased to 1.0 g (4 capsules) 3 times a day. The maximum daily dose is 6 g (24 capsules). For the treatment of acute otitis media, 0.5 g (2 capsules) is prescribed 3 times a day. Children aged 5 to 10 years (weighing 20 to 40) are prescribed 0.25 g (1 capsule) 3 times a day. The course of treatment is 5-12 days (with streptococcal infections – at least 10 days). For patients with creatinine clearance below 10 ml per minute, the dose of the drug is reduced by 15-50%, with anuria, the dose should not exceed 2 g per day. For the treatment of uncomplicated gonorrhea, 3.0 g is prescribed once (preferably in combination with 1.0 g of probenecid). For the prevention of endocarditis, 3.0 g is prescribed once 1 hour before surgery and 1.5 g after 6-8 hours. For the treatment and prevention of anthrax, adults and children weighing more than 20 kg are prescribed 0.5 g (2 capsules) every 8 hours for 2 months. Use during pregnancy and lactation Data on the possible embryotoxic, teratogenic or mutagenic effects of amoxicillin when taken during pregnancy are currently not available. During pregnancy, they are used for health reasons, taking into account the expected effect for the mother and the potential risk to the fetus. The use of amoxicillin during lactation is contraindicated (it is necessary to stop breastfeeding for the duration of treatment). Amoxicillin passes into breast milk, which can lead to the development of sensitization phenomena in a child. Precautions In the process of long-term therapy, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys. Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy. When administered to patients with sepsis, it is possible to develop a bacteriolysis reaction (Jarish-Herxheimer reaction) (rarely). Patients with gonorrhea should have serological tests for syphilis at the time of diagnosis. Patients treated with amoxicillin should have a follow-up serological control for syphilis after 3 months. Use with caution in patients prone to allergic reactions. Influence on the ability to drive vehicles and other potentially dangerous mechanisms. Use the drug with caution in persons taking high doses of amoxicillin for a long time. Interaction with other drugs Reduces the effectiveness of estrogen-containing oral contraceptives, drugs, in the process of metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol – the risk of bleeding “breakthrough”. Reduces clearance and increases the toxicity of methotrexate. Enhances the absorption of digoxin. Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index). Monitoring of prothrombin time should be carried out with simultaneous administration with anticoagulants. Antacids, glucosamine, laxatives slow down and reduce, and ascorbic acid increases absorption. Excretion is slowed down by probenecid, allopurinol, sulfinpyrazone, acetylsalicylic acid, indomethacin, oxyphenbutazone, phenylbutazone, and other drugs that suppress tubular secretion. Antibacterial activity decreases when used simultaneously with bacteriostatic chemotherapeutic agents, increases when combined with aminoglycosides and metronidazole. There is a complete cross-resistance of ampicillin and amoxicillin. Contraindications Hypersensitivity (including to other drugs from the group of penicillins, cephalosporins, carbapenems), allergic diathesis, bronchial asthma, hay fever, infectious mononucleosis, lymphocytic leukemia, history of colitis associated with the use of antibiotics. The drug should not be prescribed to patients with infectious mononucleosis, lymphocytic leukemia, as they often develop an erythematous rash while taking amoxicillin. If a skin rash occurs, amoxicillin should be discontinued. Composition Active substance: amoxicillin (as amoxicillin trihydrate) – 250 mg. OverdoseSymptoms: nausea, vomiting, diarrhea, impaired water and electrolyte balance. Treatment: gastric lavage, administration of activated charcoal, saline laxatives, correction of water and electrolyte balance, hemodialysis. Side effects Allergic reactions: possible urticaria, skin flushing, erythematous rashes, angioedema, rhinitis, conjunctivitis; rarely – fever, arthralgia, eosinophilia, exfoliative dermatitis, erythema multiforme exudative (including Stevens-Johnson syndrome); reactions similar to serum sickness; in isolated cases – anaphylactic shock. From the digestive system: a change in taste, nausea, vomiting, stomatitis, glossitis, dysbacteriosis, diarrhea, pain in the anus, rarely – pseudomembranous enterocolitis. From the side of the liver and biliary tract: a moderate increase in the activity of “liver” transaminases, rarely – hepatitis and cholestatic jaundice. From the nervous system (with prolonged use in high doses): agitation, anxiety, insomnia, ataxia, confusion, behavioral changes, depression, peripheral neuropathy, headache, dizziness, convulsions. Laboratory changes: leukopenia, neutropenia, thrombocytopenic purpura, transient anemia. Other effects: shortness of breath, tachycardia, interstitial nephritis, joint pain, oral and vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance). Storage conditions In a place protected from moisture and light at a temperature not exceeding 25 C. Keep out of the reach of children. Buy Amoxicillin capsules 250 mg No. 10×3 Price for Amoxicillin capsules 250 mg No. 10×3