Alotendin tablets 10mg/5mg №10×3

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Alotendin tab. 10mg/5mg in bl. in pack. No. 10×3
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Appearance: Alotendine tablets 5/5 mg: white or almost white, oblong, slightly biconvex tablets, odorless, scored* on one side and engraved with MS on the other side. Alotendine tablets 5/10 mg: white or off-white, round, flat, beveled, odorless tablets, scored* on one side and engraved with MS on the other side. Alotendin tablets 10/5 mg: white or almost white, oval, slightly biconvex tablets, odorless, scored* on one side and debossed with MS on the other side. Alotendin tablets 10/10 mg: white or off-white, round, slightly biconvex tablets, odorless, scored* on one side and debossed with MS on the other side. *risk is only for ease of taking the pill. The main active ingredient is bisoprolol and amlodipine Release form: 7 or 10 tablets in a blister from a combined cold film: (polyamide/aluminum foil/PVC)//aluminum foil. 4 or 8 blisters (7 tablets each) or 3 or 9 blisters (10 tablets each) are placed in a cardboard box along with instructions for medical use for patients. Dosage 10mg/5mg in bl. in pack. No. 10×3 Indications for useAlotendin tablets are indicated for the treatment of high blood pressure (arterial hypertension). Alotendine can be used as a replacement therapy if your symptoms have been adequately controlled by the combined use of amlodipine tablets and bisoprolol tablets in the same doses as in the combination drug. Dosage and Administration This drug should be taken strictly in accordance with the doctor’s prescription. If you have any questions, ask your doctor or pharmacist. Dosing regimen The usual recommended dose is one tablet of the prescribed dosage for you. Special patient groups Impaired liver and kidney function Usually, with mild to moderate functional insufficiency of the liver and kidneys, there is no need for dose adjustment. In case of severe impairment of liver and kidney function, the dosage may be changed. Elderly patients In elderly patients, dosage adjustment is not required, caution when increasing the dose. Children and adolescents under the age of 18 Alotendine tablets are not recommended for use in children, since the safety and efficacy of this drug in this category of patients have not been confirmed. Method of application Alotendin tablets are preferably taken in the morning, regardless of the meal, with a small amount of liquid and without chewing. The risk is intended only for the convenience of taking the pill. It can break the tablet if you find it difficult to take it whole. If you think that the therapeutic effect of Alotendin tablets is excessive or insufficient, consult your doctor or pharmacist. If you have taken more tablets than prescribed If you have taken more Alotendine tablets than you should, contact your doctor immediately. If you forget to take a tablet Try to take the missed dose as soon as possible. If it is already time for the next dose, do not take a double dose to make up for the missed dose, as you will not be compensated but may increase the risk of overdose. If you stop taking the drug Do not stop taking the drug suddenly or change the recommended dose without talking to your doctor, as this may cause temporary worsening of heart failure. Treatment should not be stopped abruptly, especially in patients with coronary artery disease. If discontinuation of treatment is required, the dose should be reduced gradually. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. Use during pregnancy and lactation If you are pregnant, breastfeeding, think you are pregnant or plan to have a child, tell your doctor or pharmacist before using this medicine. Pregnancy Given the fact that there is no proper clinical experience with the use of the drug in pregnant women, it can only be prescribed after a careful individual assessment of the risk / benefit ratio by the attending physician, therefore, warn your attending physician about a possible pregnancy or its planning. If the drug is prescribed during pregnancy, careful monitoring of the condition of the fetus and newborn may be required. Breast-feeding Given the lack of relevant clinical experience, this drug is not recommended for use in nursing mothers. Consult your healthcare professional before taking any medicine if you are pregnant or breastfeeding. Precautions: Talk to your doctor or pharmacist before you start using Alotendin. In the following conditions, Alotendine tablets should be taken with caution, so be sure to tell your doctor if you have any of the following conditions: advanced age; heart failure; diabetes mellitus with large fluctuations in blood sugar levels; strict diet; parallel anti-allergic (desensitizing) treatment (for example, to prevent allergic rhinitis); small violations of the conduction system of the heart (first-degree AV block); impaired perfusion of the coronary arteries (Prinzmetal’s angina); vascular diseases of the extremities, characterized by a decrease in perfusion; psoriasis; hyperthyroidism; diseases of the liver and kidneys; treated pheochromocytoma, which is a rare tumor of the adrenal medulla; bronchial asthma or chronic obstructive pulmonary disease; If you are going to have surgery, tell the anesthesiologist that you are taking Alotendine tablets. If you have any of the problems listed above, your doctor may decide that you need special help (such as additional medications). Children and adolescents under 18 years of age This medicinal product should not be used in children under 18 years of age due to the lack of safety and efficacy data in this age group of patients. Interactions with other drugs Therapeutic and side effects of this drug may be affected by other drugs taken at the same time. Interactions may occur even if other drugs are taken for a short period of time. Tell your doctor or pharmacist about any medicines you are taking, have recently taken or may take, including over-the-counter medicines. Co-administration of the following drugs is not recommended: Calcium channel blockers such as verapamil and diltiazem: These drugs are used to treat high blood pressure and chronic stable angina. Centrally acting antihypertensives (eg, clonidine, methyldopa, moxonodine, rilmenidine): Do not stop taking these drugs without first talking to your doctor. The following drugs may be given together only in certain situations, with extreme caution and subject to the possibility of medical supervision: Certain drugs that affect the heart rhythm (quinidine, disopyramide, lidocaine, phenytoin, flecainide, propafenone, amiodarone). These drugs are used to treat arrhythmias and other heart rhythm disorders. Topical dosage forms of beta-blockers (for example, eye drops in the treatment of glaucoma). Parasympathomimetics. These drugs are used to enhance smooth muscle function in diseases of the stomach, small intestine, bladder, and glaucoma. Insulin and oral antidiabetic agents. Sleeping pills and painkillers. Cardiac glycosides (digitalis preparations), drugs used to treat heart failure. Non-steroidal anti-inflammatory drugs (NSAIDs). These drugs may be prescribed to treat joint inflammation, pain, or arthritis. Sympathomimetics (eg, isoprenaline, dobutamine, norepinephrine, epinephrine). These drugs are used to treat serious circulatory disorders in emergency situations. Any drugs that cause a decrease in blood pressure due to their therapeutic or undesirable effects (for example, antihypertensive drugs, tricyclic antidepressants, barbiturates, phenothiazines). Dantrolene infusion for the treatment of severe changes in body temperature. Tacrolimus, cyclosporine – immunosuppressive drugs – drugs that suppress the activity of the immune system. Simvastatin is a cholesterol-lowering drug. Your doctor should decide whether to prescribe the following drugs together with the tablets: Mefloquine, used to prevent or treat malaria. Monoamine oxidase (MAO) inhibitors used to treat depression. Drugs that affect the metabolism of amlodipine or bisoprolol (for example, rifampicin, ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, indinavir, nelfinavir and preparations containing St. John’s wort). Ergotamine derivatives (drugs for the treatment of gynecological bleeding). Interactions with food, drink and alcohol Alcohol may potentiate the hypotensive (lowering blood pressure) effect of this drug. The tablets can be taken with or without food. Contraindications If you are allergic to amlodipine, bisoprolol (active ingredients), digyropyridine derivatives or any of the excipients of Alotendine Tablets; If you have a severe obstruction in the ejection of blood from the left ventricle (severe narrowing of the aorta); If you have acute heart failure, or heart failure after an acute myocardial infarction, requiring intravenous administration of drugs to increase the force of contraction of the heart muscle; if you are in shock caused by impaired heart function (blood pressure is extremely low with collapse of the circulatory system); if you have a heart condition characterized by a very slow heart rate or irregular beats (2nd or 3rd degree atrioventricular block, sinoatrial block, sick sinus syndrome); If you have a pronounced decrease in blood pressure (the first value is persistently below .Hg); If you have severe bronchial asthma or chronic obstructive pulmonary disease; If you have a serious pathology of peripheral arteries; If you have Raynaud’s syndrome, which is characterized by numbness, “humming” and blanching of the fingers and toes when exposed to cold; If you have pheochromocytoma, which is a rare tumor of the adrenal medulla for which you have not received treatment; With metabolic changes, when the pH of the blood changes towards acidity. If you think you have any of the conditions listed above, ask your doctor if you can take this drug. Active ingredients: bisoprolol and amlodipine. Excipients: anhydrous colloidal silicon dioxide, magnesium stearate, sodium starch glycolate (type A), microcrystalline cellulose. Side effects Like all medicines, this medicine can cause side effects, although not everyone gets them. If you experience any of the following, please consult your healthcare professional: Very common side effects (affects more than 1 in 10 people): swelling of the ankles. Common side effects (may affect up to 1 in 10 patients): headache, dizziness, drowsiness (especially at the beginning of treatment), visual disturbances (including double vision), palpitations, hot flashes, shortness of breath, abdominal pain, swelling of the ankles, muscle cramps, fatigue, asthenia, feeling of chilliness and numbness in the limbs, gastrointestinal disorders: nausea, vomiting, indigestion, bowel irregularity (including diarrhea and constipation). Uncommon side effects (may affect up to 1 in 100 patients): insomnia, mood changes (including anxiety), depression, brief loss of consciousness (syncope), hypoesthesia, paresthesia, taste changes, tremor, tinnitus, cardiac arrhythmia , lowering blood pressure (hypotension), cough, runny nose, dry mouth, small hemorrhages in the skin and mucous membranes (purpura), discoloration of the skin, increased sweating, itching, skin rashes, exanthema, urticaria, arthralgia (joint pain), myalgia (muscle pain), back pain, urinary frequency, urination disorder, nocturia (nighttime urination), impotence, male breast enlargement, chest pain, pain, feeling unwell, weight gain or loss, sleep disturbances, cardiac conduction, worsening of existing heart failure, slow heart rate (less than 50 beats per minute), bronchospasm in patients with bronchial history of asthma or obstructive pulmonary disease, muscle weakness, exhaustion*. *This symptom is mostly observed at the beginning of treatment and is usually not severe and often resolves in 1-2 weeks. Rare side effects (occurs in less than 1 patient in 1000): confusion, increased blood triglycerides, nightmares, hallucinations (erroneous perception that occurs in the absence of detectable stimuli, similar to a real sensation and seems real to a person), decreased secretion of tear fluid (this should be considered if you wear contact lenses), hearing loss, allergic rhinitis, hepatitis, hypersensitivity reactions such as itching, flushing, rash, increased levels of liver enzymes. Very rare side effects (may affect up to 1 in 10,000 people): decrease in white blood cells and platelets, allergic reactions, high blood sugar, hypertension, peripheral neuropathy, myocardial infarction, focal inflammation of small vessels (vasculitis ), gastritis, gingival hyperplasia, pancreatitis, jaundice, angioedema (acute swelling of the skin or mucous membranes, most often on the eyelids, lips, joints, genitals, glottis, pharynx and tongue), severe inflammation of the skin or mucous membranes with the formation of red blisters (erythema multiforme), severe redness and peeling of the skin (exfoliative dermatitis), blisters on the skin or mucous membranes of the mouth, genitals and anal area, with fever, sore throat and fatigue (Stevens-Johnson syndrome), photosensitivity, conjunctivitis; drugs with a mechanism of action similar to bisoprolol (the active ingredient of the drug) can cause psoriasis (a chronic skin disease in which itchy, flaky red spots appear on the skin) or worsen its course, or cause psoriasis-like skin changes. Such drugs can cause extrapyramidal symptoms (combination of involuntary movements, stiffness and muscle contractions, and tremors (shaking)). Reporting side effects If you experience any side effects, including those not mentioned in this leaflet, please contact your doctor or pharmacist. By reporting side effects, you can help provide more information about the safety of this medicine. Storage conditions Store at a temperature not exceeding 30 ° C, out of the reach of children! Buy Alotendin tablets 10mg / 5mg No. 10×3