Aevit capsules №15×2

Name Aevit The main active ingredient Retinol + vitamin e Release form capsules Special instructions The drug is used with caution in patients with an increased risk of thromboembolism, severe atherosclerosis of the coronary arteries, chronic circulatory failure, with acute or chronic nephritis, cholecystitis, with severe lesions of the hepatobiliary system. It is not recommended to prescribe for a long time together with other multivitamin preparations, because. an overdose of fat-soluble vitamins (A and E) is possible. Dosing instructions must be strictly observed, as hypervitaminosis A is possible. When using the drug, one should take into account the high content of vitamin A in it (100 thousand IU), and also that it is a therapeutic, not a preventive drug. Pharmacodynamics A combined drug, the action of which is determined by the properties of the fat-soluble vitamins A and E included in its composition. Retinol (vitamin A) is a fat-soluble vitamin, as a cofactor plays an important role in redox processes, participates in the synthesis of mucopolysaccharides, proteins, lipids. It is essential for normal reproductive function, embryonic development, epithelial proliferation and differentiation, and osteogenesis. Participates in the formation of visual pigments necessary for normal twilight and color vision. Retinol improves immunity, weakens the effects of a number of infectious diseases, and can prevent the development of malignant neoplasms. Alpha-tocopheryl acetate (vitamin E) has antioxidant properties, preventing the action of free radicals on biological membranes and is involved in protein synthesis, cell proliferation, and tissue respiration. It maintains the stability of erythrocytes and prevents their hemolysis, prevents increased permeability and fragility of capillaries, increases the resistance of tissues to hypoxia, and has a positive effect on impaired lipid metabolism. Vitamin E helps prevent spontaneous abortion, normalize the function of the gonads in men, restore skeletal muscles in case of muscular dystrophy and other muscle damage. In cardiovascular diseases in complex therapy, vitamin E contributes to the normalization of metabolism in the heart muscle, increases the rate of blood flow in arterioles, and maintains tension in venules. PharmacokineticsRetinol palmitate is well absorbed in the upper small intestine, penetrates into the lymphatic tract and enters the liver. After administration, the maximum plasma concentration is reached after 4 hours. Retinol is distributed unevenly in the body. Its largest amount is found in the liver and retina, it is found in the kidneys, fat depots, adrenal glands and other endocrine glands. Retinol metabolic products are excreted by the kidneys. The half-life is 9.1 hours. Alpha-tocopheryl acetate is absorbed in the gastrointestinal tract, most of it enters the lymph, quickly distributed in all tissues, excreted in the bile and as metabolites in the urine. Indications for use Hypo- and avitaminosis A and E; states of increased need of the body for vitamins A and E and / or a decrease in their intake into the body; with increased physical and mental stress, stressful conditions; during the recovery period after prolonged and / or severe diseases, including infectious ones; with asthenic conditions of various etiologies; with unbalanced and inadequate nutrition. Dosage and administrationAevit capsules are taken orally, regardless of food intake, 1 capsule daily for 20-40 days at intervals of 3-6 months. Use during pregnancy and lactation The drug is contraindicated in pregnancy. The teratogenic effect of increased doses of vitamin A persists even after stopping its use, therefore it is recommended to plan a pregnancy when using the drug only after 6-12 months. Precautions Impact on the ability to drive a car, work with machinery Does not affect. Interaction with other drugs With the simultaneous use of vitamin A weakens the effect of Ca2 + drugs, increases the risk of hypercalcemia. Colestyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamin A and E (may require an increase in their dose). Oral contraceptives increase the plasma concentration of vitamin A. Retinol reduces the anti-inflammatory effect of glucocorticoids. Isotretinoin increases the risk of developing vitamin A intoxication. The simultaneous use of tetracycline and vitamin A in high doses (50 thousand units and above) increases the risk of developing intracranial hypertension. Vitamin E enhances the effect of corticosteroids, NSAIDs, antioxidants, increases the effectiveness and reduces the toxicity of vitamins A, D, cardiac glycosides. Vitamin E increases the effectiveness of antiepileptic drugs in patients with epilepsy (in whom the content of lipid peroxidation products in the blood is increased). The simultaneous use of vitamin E at a dose of more than 400 units / day with anticoagulants (coumarin and indandione derivatives) increases the risk of developing hypoprothrombinemia and bleeding. High doses of Fe enhance oxidative processes in the body, which increases the need for vitamin E. Alpha-tocopheryl acetate is not recommended to be taken in combination with preparations of gold, silver, alkaline-reactive agents. Corticosteroid drugs, antibiotics of the tetracycline group, as well as ethanol and ethanol-containing drugs, when used together with Aevit, reduce the therapeutic effect. Contraindications Contraindications to the use of Aevit capsules are hypervitaminosis A and E, thyrotoxicosis, chronic glomerulonephritis, chronic heart failure, hypersensitivity to the components of the drug, history of sarcoidosis, cholelithiasis, chronic pancreatitis, children and adolescents under 18 years of age. The drug is contraindicated in pregnancy. Composition Retinol palmitate – 100,000 IU, alpha-tocopheryl acetate – 100 mg. Overdose Symptoms of an overdose of vitamin A: a single dose of a large amount of the drug is accompanied by a sudden increase in CSF pressure (without pathological changes in the CSF itself), severe headache, drowsiness, visual impairment (diplopia). In severe cases, convulsive seizures, heart failure develop. With prolonged use, chronic hypervitaminosis A may develop, which is manifested by lesions of the nervous system (headache, insomnia, irritability, apathy, paresthesia), general weakness, loss of appetite, fever, changes in the skin (dryness and cracks in the skin on the palms and feet , the appearance of age spots, hair loss, seborrheic rash), jaundice, pain in the bones and muscles, gait disorders, enlargement of the liver and spleen, swelling of the optic nerve head, changes in the blood picture. Symptoms of an overdose of vitamin E: creatinuria, diarrhea, epigastric pain, decreased performance, hepatomegaly, hyperbilirubinemia (more than 20 mg / dl), azotemia (more than 40 mg / dl), thrombocytopenia (less than 50-60 thousand / μl), symptoms of renal insufficiency, hemorrhage in the retina and brain, ascites. Treatment: symptomatic; L-thyroxine and ascorbic acid are prescribed as an antagonist. It is necessary to cancel the drug. Side effect On the part of the digestive system: loss of appetite, dryness of the oral mucosa, stomach pain, vomiting, nausea. From the side of the liver and biliary system: hepatotoxic effects, portal hypertension. On the part of the skin and subcutaneous tissue: cracks and dryness of the skin, lips, yellow-orange spots on the soles, palms, in the nasolabial triangle, subcutaneous edema, in some cases, on the first day of use, itchy maculopapular rashes may occur, which requires discontinuation of the drug . From the nervous system: asthenia, excessive fatigue, drowsiness, discomfort, headache, irritability, intraocular hypertension, visual impairment, gait disturbance. From the endocrine system: oligomenorrhea. From the urinary system: pollakiuria, nocturia, polyuria. From the blood system: hemolytic anemia. From the musculoskeletal system: bone pain, hyperostosis of long bones (mainly in children), premature closure of the epiphyseal growth zones. Others: hyperthermia, hair loss, photosensitivity, weight loss, hypercalcemia. With a decrease in the dose or temporary withdrawal of the drug, side effects are carried out independently. In skin diseases, the use of high doses of the drug after 7-10 days of treatment may be accompanied by an exacerbation of the local inflammatory reaction, which does not require additional treatment and subsequently decreases. This effect is associated with myelo- and immunostimulatory effects of the drug. Storage conditions Shelf life 2 years. Do not use after the expiry date stated on the packaging. To store in the place protected from moisture and light at a temperature from 15 °C to 25 °C. Keep out of the reach of children. Buy Aevit capsules No. 15×2 Price for Aevit capsules No. 15×2 Instructions for use for Aevit capsules No. 15×2