Acetylsalicylic acid tablets 500mg №10×2

NameAcetylsalicylic acid tablets 500mg №10×2 CompositionFor one tablet: active ingredient: acetylsalicylic acid – 500.0 mg; excipients: talc, calcium stearate, citric acid monohydrate, anhydrous colloidal silicon dioxide, potato starch. Pharmacotherapeutic group Other analgesics and antipyretics. Salicylic acid and its derivatives. ATC code: N02BA01. Pharmacological action Acetylsalicylic acid belongs to the group of acidic NSAIDs with analgesic, antipyretic and anti-inflammatory properties. The mechanism of its action is based on the irreversible inhibition of type I and type II cyclooxygenases – enzymes involved in the synthesis of prostaglandins. In doses of 0.3 g to 1.0 g, it is used to treat mild to moderate pain and fever, such as with colds or flu, to reduce fever and treat joint and muscle pain. Acetylsalicylic acid also inhibits platelet aggregation by blocking the synthesis of thromboxane Ag in platelets. For this reason, it is used in certain cardiovascular diseases, in doses of 75-300 mg per day. Indications for use – fever; – pain syndrome of weak and moderate intensity of various origins. Dosage and administration To reduce the irritating effect on the gastrointestinal tract, the drug should be taken after meals with water, milk or alkaline mineral water. For pain syndrome of mild and moderate intensity and febrile conditions for children over 15 years of age and the elderly, a single dose is 500 mg (1 tablet), for adults – 1000 mg (2 tablets). If necessary, the drug can be taken 3 times a day with an interval of at least 4 hours. The maximum daily dose for children over 15 years old is 1500 mg (3 tablets), for adults – 3000 mg (6 tablets). Do not take the drug for more than 5 days as an analgesic and more than 3 days as an antipyretic without a doctor’s prescription. Side effects When assessing the frequency of adverse reactions, the following gradation is used: Very often: ? 1/10; Often: <1/10,? 1/100; Uncommon: <1/100,? 1/1000; Rare: < 1/1000,? 1/10000; Very rare: < 1/10000; Unknown: Frequency cannot be estimated due to lack of data. On the part of the blood and lymphatic system: Rarely and very rarely - serious bleeding, such as cerebral hemorrhage, especially in patients with uncontrolled arterial hypertension and / or with simultaneous anticoagulant therapy, which in some cases can be life-threatening. Hemolysis and hemolytic anemia in patients with severe glucose-6-phosphate dehydrogenase deficiency. Epistaxis, bleeding gums, skin bleeding or bleeding from the urogenital tract with possible prolongation of bleeding time. These effects persist for 4-8 days from the moment of discontinuation of the drug. From the gastrointestinal tract: rarely - heartburn, nausea, vomiting, epigastric pain; erosive and ulcerative lesions (in rare cases can lead to perforation), gastrointestinal bleeding, which can lead to iron deficiency anemia, inflammatory conditions of the gastrointestinal tract. From the side of the central nervous system: Dizziness, headache, tinnitus, hearing loss, confusion (usually a sign of an overdose). On the part of the skin and subcutaneous tissue: Infrequently: skin hypersensitivity reactions, such as skin rashes. Rarely: severe skin hypersensitivity reactions (before the development of erythema multiforme exudative). From the immune system: Rarely: hypersensitivity reactions from the respiratory tract, gastrointestinal tract and cardiovascular system, especially in patients with asthma. The following symptoms may be observed: arterial hypotension, asthma attacks, rhinitis, nasal congestion, anaphylactic shock or Quincke's edema. Liver and biliary tract disorders: Very rare: increased levels of liver enzymes. Renal and urinary disorders: Renal disorders and acute renal failure have been reported. Contraindications Hypersensitivity to the substances which are a part of medicine; erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase); gastrointestinal bleeding; "aspirin" triad; hemorrhagic diathesis (hemophilia, Willibrand's disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura); bronchial asthma induced by the intake of salicylates and other NSAIDs; dissecting aortic aneurysm; severe heart failure; portal hypertension; vitamin K deficiency; taking methotrexate at a dose of 15 mg per week or more; liver / kidney failure; deficiency of glucose-6-phosphate dehydrogenase; children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases); I and III trimesters of pregnancy and lactation. OverdoseOverdose in the elderly and children requires special attention, since in these groups of patients, therapeutic overdose or accidental poisoning can be fatal. Symptoms Overdose of moderate severity: ringing in the ears, hearing loss, sweating, nausea, vomiting, headache, dizziness. Symptoms resolve with decreasing dosage. Severe overdose: high fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiovascular failure, respiratory failure, severe hypoglycemia. Actions in case of overdose The patient must be immediately brought to the hospital. Treatment - gastric lavage, the use of activated charcoal, monitoring of acid-base balance; - forced alkaline diuresis should be performed at a plasma salicylate concentration of 500 mg/l (3.6 mmol/l) in adults and 300 mg/l (2.2 mmol/l) in children. For severe poisoning, hemodialysis is indicated. Need to compensate for water loss; - symptomatic treatment. Precautions Care should be taken in the following cases: - with hypersensitivity to other analgesics, anti-inflammatory and antirheumatic drugs, in the presence of other types of hypersensitivity; - if you have a history of allergies (eg, skin reactions, itching, urticaria), asthma, hay fever, nasal polyposis, or chronic respiratory disease; - with simultaneous treatment with anticoagulants; - with peptic ulcer of the stomach and / or duodenum, erosive gastritis and a tendency to gastrointestinal bleeding; - in patients with impaired liver function; - in patients with impaired renal function and the cardiovascular system (renal vascular disease, chronic heart failure, dehydration, sepsis or severe bleeding), since acetylsalicylic acid may increase the risk of renal dysfunction and acute renal failure; - before operations (even before minor ones such as tooth extractions), this can increase the risk of bleeding; - in patients with deficiency of glucose-6-phosphate dehydrogenase, acetylsalicylic acid can cause hemolysis or hemolytic anemia. Hemolysis can be triggered by high doses, fever, or acute infections. With chronic use of pain medications, headaches can occur, which lead to repeated medications and, in turn, can prolong the headache. Chronic use of pain medications can cause permanent kidney damage with a risk of kidney failure (analgesic nephropathy). The risk increases when taking a combination of different pain medications. Acetylsalicylic acid, even in small doses, reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. Acetylsalicylic acid should be used in febrile children and adolescents only for medical reasons and only if other measures have failed. The occurrence of prolonged vomiting when using acetylsalicylic acid may be one of the signs of a life-threatening condition - Reye's syndrome, which requires immediate treatment. Application during pregnancy and lactation Use is contraindicated in the I and III trimester of pregnancy, during lactation. It has a teratogenic effect: when used in the first trimester, it leads to the development of a splitting of the upper palate; in the third trimester causes inhibition of labor activity (inhibition of the synthesis of PO), premature closure of the ductus arteriosus in the fetus, hyperplasia of the pulmonary vessels and hypertension in the "small" circle of blood circulation. In the II trimester of pregnancy, episodic use of acetylsalicylic acid is allowed. It is excreted in breast milk, which increases the risk of bleeding in a child due to impaired platelet function. At the time of treatment, breastfeeding should be stopped. Influence on the ability to drive vehicles and other potentially dangerous mechanisms During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Interactions with other medicinal products Increased effect with increased risk of side effects - Anticoagulants/thrombolytics: Aspirin may increase the risk of bleeding when taken before thrombolytic therapy. Particular attention should be paid to signs of external or internal bleeding in patients who have undergone thrombolytic therapy; - Antiplatelet drugs such as ticlopidine, clopidogrel increase the risk of bleeding; - Other non-steroidal analgesics/anti-inflammatory drugs (acetylsalicylic acid at doses of 3 g per day or more) increase the risk of gastrointestinal ulcers and bleeding; - Systemic glucocorticoids (other than hydrocortisone as replacement therapy for Addison's disease) increase the risk of gastrointestinal side effects; - Alcohol increases the risk of gastrointestinal ulcers and bleeding; - Digoxin increases plasma concentration due to decreased renal excretion; - Antidiabetic drugs lower blood sugar levels; - Methotrexate reduces excretion and displaces salicylates from binding to plasma proteins, resulting in increased toxicity; - Valproic acid displaces salicylates from binding to plasma proteins, resulting in increased toxicity; - Selective serotonin reuptake inhibitors (SSRIs) increase the risk of gastrointestinal bleeding due to synergistic effects. Reduce the effect - Diuretics (when used simultaneously with acetylsalicylic acid at a dose of 3 g per day or more); - ACE inhibitors (acetylsalicylic acid at a dose of 3 g per day or more); - Uricosuric drugs (eg probenecid, benzbromarone). Storage conditions In a place protected from moisture and light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life 2 years. Do not use after the expiry date stated on the packaging. Packing: 10 tablets in a blister pack. One, two or three blister packs together with instructions for use in a cardboard pack. Conditions of sale Without a prescription. Buy Acetylsalicylic acid tablets 500mg №10x2 Price for Acetylsalicylic acid tablets 500mg №10x2