Acetylcysteine solution for inhalation 200mg/ml in ampoules 5ml №10

Name:
Acetylcysteine solution for injection.200mg/ml in amp.5ml in pack No. 10
Description:
Transparent colorless solution with a specific odor. When opening the ampoules, the solution may acquire a violet-pink color. The main active ingredientAcetylcysteine Form releaseSolution for inhalation Dosage 200mg/ml Special instructionsAcetylcysteine is incompatible with most metals and is inactivated by oxidizing agents. Therefore, if possible, devices with glass or plastic parts (but not rubber) should be used when using the drug. If devices with metal or rubber parts are used, rinse immediately with water after use. Acetylcysteine should not be used in conjunction with other drugs, in particular antibiotics, in the same solution or in the same kit due to lack of compatibility data. Pharmacological action Mucolytic agent. Liquefies sputum, increases its volume, facilitates sputum separation, promotes expectoration. The action of the drug is associated with the ability of free sulfhydryl groups of acetylcysteine to break intra- and intermolecular disulfide bonds of sputum acid mucopolysaccharides, which leads to depolymerization of mucoproteins and a decrease in sputum viscosity (in some cases this leads to a significant increase in sputum volume, which requires aspiration of bronchial contents). The drug remains active in the presence of purulent sputum. It has an antioxidant effect due to the presence of the SH group, which is able to interact and neutralize electrophilic oxidative toxins. Acetylcysteine promotes an increase in the synthesis of glutathione, which is an important antioxidant factor in intracellular protection and maintains the functional activity and morphological integrity of the cell. Does not affect immunity. Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates the mucous cells of the bronchi, the secret of which lyses fibrin. It has a similar effect on the secret formed in inflammatory diseases of the upper respiratory tract. Protects alpha1-antitrypsin (an elastase inhibitor) from the inactivating effects of HOCI, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has some anti-inflammatory action (due to the suppression of the formation of free radicals and active oxygen-containing substances responsible for the development of inflammation in the lung tissue). Indications for use Acute and chronic diseases of the respiratory system, accompanied by increased formation of a viscous, hard-to-remove secret. Dosage and administrationAdults: 3 ml of a 10% solution (300 mg of acetylcysteine) 1-2 times a day. Children (at the age at which active participation is guaranteed): 1.5 ml of a 10% solution (150 mg of acetylcysteine) 1-2 times a day. Duration of treatment: 5-10 days. For aerosol therapy of respiratory diseases, ultrasound devices and devices with a control valve can be used. If the drug is well tolerated, the frequency of use and doses can be changed by the doctor, taking into account the clinical condition and therapeutic effect, without the need to differentiate doses for adults and children. Method of application The ampoule of acetylcysteine is opened before use. To obtain a 10% (100 mg/ml) solution, the initial 20% (200 mg/ml) solution of acetylcysteine is diluted with water for injection in a ratio of 1:1. When diluted, the solution may acquire a violet-pink color. The opened ampoule and ready-made solution for inhalation can be stored at a temperature of 2 ° C to 8 ° C for 24 hours (see section “Shelf life”). When acetylcysteine solution is mixed with bronchodilators or other drugs, it should be used as soon as possible and should not be stored. Use during pregnancy and lactation Pregnancy Limited data on the use of the drug during pregnancy have not shown an adverse effect on the course of pregnancy or on the health of the fetus or newborn. There is no experience of epidemiological studies. Animal studies have not revealed direct or indirect toxic effects on pregnancy, embryonic development, fetal development and / or postnatal development. Use during pregnancy is contraindicated. Lactation Data on the intake of acetylcysteine in breast milk are not available. Acetylcysteine should not be used during breastfeeding. Precautions The combined use of acetylcysteine and antitussive drugs is not recommended. The simultaneous use of these drugs can lead, by inhibition of the cough reflex and physiological self-cleaning of the airways, to the accumulation of secretions with the risk of bronchospasm and upper respiratory tract infection. The drug should be used with caution in patients with bronchial asthma. In the event of hypersensitivity reactions or bronchospasm, the drug should be stopped immediately and appropriate measures should be taken. Acetylcysteine should be used with caution in patients with a history of peptic ulcer, especially in the case of concomitant use of other drugs that irritate the gastric mucosa. The use of acetylcysteine, mainly at the beginning of therapy, can dilute the secret of the bronchial glands and increase its volume. If the patient is unable to effectively cough up sputum, postural drainage and bronchial aspiration should be performed. When working with the drug, it is necessary to use glassware, avoid contact with metals and rubber (the formation of sulfides with a characteristic odor is possible), easily oxidizing substances. The faint sulfuric odor of the solution is the characteristic odor of the active substance. The use of acetylcysteine may change the results of the quantitative determination of salicylates by the colorimetric method and the results of the determination of ketones in urine. Interaction with other drugs Interaction studies of acetylcysteine with other drugs have only been performed in adults. The simultaneous use of acetylcysteine and antitussives can lead to the accumulation of bronchial secretions due to the suppression of the cough reflex, so the combined use of these drugs is not recommended. It is also recommended to avoid the simultaneous use of mucolytics and other substances that inhibit secretion (for example, anticholinergics). Acetylcysteine can be used together with bronchodilators and vasoconstrictors. There are literature data on the in vitro interaction of N-acetylcysteine and a number of antibiotics, which indicate a decrease in the activity of antibiotics. In particular, due to the presence of a thiol group (-SH), N-acetylcysteine can react chemically with various penicillins, tetracyclines, cephalosporins, aminoglycosides, macrolides and amphotericin B if these substances are mixed in the same solution. Therefore, as a precaution, it is not recommended to mix the solution of N-acetylcysteine and antibiotics. The combined use of acetylcysteine and nitroglycerin may enhance the vasodilating and antiplatelet effects of the latter. If the combined use of nitroglycerin and N-acetyl cysteine is necessary, blood pressure should be monitored in patients. Patients should be warned about the possibility of lowering blood pressure, which can be severe and accompanied by headache. Contraindications – hypersensitivity to acetylcysteine or other components of the drug; – peptic ulcer of the stomach and duodenum in the acute stage; – hemoptysis, pulmonary bleeding; – pregnancy, lactation; – children’s age up to 6 years. With caution: gastric ulcer and duodenal ulcer in remission, esophageal varicose veins, bronchial asthma, adrenal disease, liver and / or kidney failure, arterial hypertension. Composition Per ampoule: active substance: acetylcysteine – 1000.0 mg; excipients: disodium edetate, sodium hydroxide 2 M solution, water for injection. OverdoseSymptoms: high doses of the drug can initiate the release of a large amount of bronchopulmonary secretion, which can lead to airway obstruction. Treatment: mechanical removal of mucus from the tracheobronchial tree. Side effects Like all medicines, acetylcysteine can cause side effects, although not everyone gets them. Stop taking acetylcysteine immediately and contact your doctor if you experience the following adverse reactions: frequency unknown (frequency cannot be estimated from the available data): hypersensitivity reactions, bronchospasm, bronchial obstruction. When using acetylcysteine, the following adverse reactions may also occur: the frequency is unknown (based on the available data, the frequency of occurrence cannot be determined): rhinorrhea, stomatitis, nausea, vomiting, urticaria, rash, itching. Reporting an undesirable effect If you experience side effects, tell your doctor about it. This also applies to any side effects not listed in this package insert. Storage conditions Store in a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Buy Acetylcysteine solution for inhalation 200mg/ml in ampoules 5ml №10 Price for Acetylcysteine solution for inhalation 200mg/ml in ampoules 5ml №10